C4B63_78g44

proteasome regulatory non-ATPase subunit

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102002 OG7: OG7_0007046 40 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 40 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_10g511 ⚠ 26S proteasome regulatory non-ATPase subunit	—	OG6 TCSYLVIO_009688 ↔ TCSYLVIO_010720 OG6 LdBPK_071300.1 ↔ LdBPK_290120.1 OG6 Tb927.3.5520 ↔ Tb927.8.570 OG7 TCSYLVIO_009688 ↔ TCSYLVIO_010720 +2 more	Both
C4B63_23g31 26S protease regulatory subunit	—	OG6 Tb927.10.3520 ↔ Tb927.8.570 OG6 LdBPK_030520.1 ↔ LdBPK_071300.1 OG6 TCSYLVIO_004491 ↔ TCSYLVIO_009688	OG6
C4B63_46g106 proteasome regulatory ATPase subunit 2	—	OG6 LdBPK_071300.1 ↔ LdBPK_130990.1 OG6 Tb927.11.3740 ↔ Tb927.8.570 OG6 TCSYLVIO_003002 ↔ TCSYLVIO_009688	OG6
C4B63_6g421 proteasome regulatory non-ATPase subunit 2	—	OG6 LdBPK_071300.1 ↔ LdBPK_281850.1 OG6 TCSYLVIO_002611 ↔ TCSYLVIO_009688 OG6 Tb927.11.9220 ↔ Tb927.8.570 OG7 Tb927.11.9220 ↔ Tb927.8.570 +2 more	Both
C4B63_76g37 proteasome regulatory ATPase subunit 5	—	OG6 LdBPK_071300.1 ↔ LdBPK_220490.1 OG6 TCSYLVIO_001259 ↔ TCSYLVIO_009688 OG6 Tb927.7.2550 ↔ Tb927.8.570	OG6
C4B63_14g170 19S proteasome regulatory subunit	—	OG6 LdBPK_071300.1 ↔ LdBPK_364570.1 OG6 Tb927.10.9740 ↔ Tb927.8.570 OG6 TCSYLVIO_004751 ↔ TCSYLVIO_009688	OG6
C4B63_4g92 19S proteasome non-atpase subunit 8	—	OG6 LdBPK_071300.1 ↔ LdBPK_320400.1 OG6 TCSYLVIO_006095 ↔ TCSYLVIO_009688 OG6 Tb927.10.14530 ↔ Tb927.8.570 OG7 LdBPK_071300.1 ↔ LdBPK_320400.1 +2 more	Both
C4B63_80g34 proteasome regulatory non-ATPase subunit 7	—	OG6 LdBPK_071300.1 ↔ LdBPK_322960.1 OG6 Tb927.11.16030 ↔ Tb927.8.570 OG6 TCSYLVIO_005383 ↔ TCSYLVIO_009688 OG7 LdBPK_071300.1 ↔ LdBPK_322960.1 +2 more	Both
C4B63_17g111 proteasome regulatory non-ATP-ase subunit	—	OG6 LdBPK_071300.1 ↔ LdBPK_321260.1 OG6 TCSYLVIO_004183 ↔ TCSYLVIO_009688 OG6 Tb927.11.14430 ↔ Tb927.8.570 OG7 LdBPK_071300.1 ↔ LdBPK_321260.1 +2 more	Both
C4B63_4g528 proteasome regulatory non-ATP-ase subunit 9	—	OG6 LdBPK_071300.1 ↔ LdBPK_191100.1 OG6 TCSYLVIO_005996 ↔ TCSYLVIO_009688 OG6 Tb927.10.15720 ↔ Tb927.8.570 OG7 LdBPK_071300.1 ↔ LdBPK_191100.1 +2 more	Both
C4B63_47g88 proteasome regulatory non-ATPase subunit 11	—	OG6 LdBPK_071300.1 ↔ LdBPK_340670.1 OG6 Tb927.10.2980 ↔ Tb927.8.570 OG6 Tb927.10.3030 ↔ Tb927.8.570 OG6 TCSYLVIO_004531 ↔ TCSYLVIO_009688 +4 more	Both
C4B63_76g43 proteasome regulatory ATPase subunit 1	—	OG6 LdBPK_071300.1 ↔ LdBPK_220440.1 OG6 TCSYLVIO_001254 ↔ TCSYLVIO_009688 OG6 Tb927.7.2500 ↔ Tb927.8.570	OG6
C4B63_79g28 ⚠ proteasome regulatory non-ATP-ase subunit 5	—	OG6 TCSYLVIO_007986 ↔ TCSYLVIO_009688 OG6 LdBPK_071300.1 ↔ LdBPK_210840.1 OG6 Tb927.10.1550 ↔ Tb927.8.570 OG7 Tb927.10.1550 ↔ Tb927.8.570 +2 more	Both
C4B63_79g26 ⚠ proteasome regulatory non-ATP-ase subunit 5	—	OG6 TCSYLVIO_007986 ↔ TCSYLVIO_009688 OG6 LdBPK_071300.1 ↔ LdBPK_210840.1 OG6 Tb927.10.1550 ↔ Tb927.8.570 OG7 Tb927.10.1550 ↔ Tb927.8.570 +2 more	Both
C4B63_34g309 proteasome regulatory non-ATPase subunit 6	—	OG6 Tb927.2.2440 ↔ Tb927.8.570 OG6 LdBPK_020340.1 ↔ LdBPK_071300.1 OG6 TCSYLVIO_000894 ↔ TCSYLVIO_009688 OG7 Tb927.2.2440 ↔ Tb927.8.570 +2 more	Both
C4B63_202g4 ⚠ proteasome regulatory ATPase subunit 3	—	OG6 TCSYLVIO_006982 ↔ TCSYLVIO_009688 OG6 LdBPK_071300.1 ↔ LdBPK_120190.1 OG6 Tb927.6.1090 ↔ Tb927.8.570	OG6
C4B63_89g62 ⚠ proteasome regulatory ATPase subunit 3	—	OG6 TCSYLVIO_006982 ↔ TCSYLVIO_009688 OG6 LdBPK_071300.1 ↔ LdBPK_120190.1 OG6 Tb927.6.1090 ↔ Tb927.8.570	OG6
C4B63_10g510 ⚠ 26S proteasome regulatory non-ATPase subunit	—	OG6 TCSYLVIO_009688 ↔ TCSYLVIO_010720 OG6 LdBPK_071300.1 ↔ LdBPK_290120.1 OG6 Tb927.3.5520 ↔ Tb927.8.570 OG7 TCSYLVIO_009688 ↔ TCSYLVIO_010720 +2 more	Both
C4B63_2g527 proteasome regulatory non-ATPase subunit 3	—	OG6 LdBPK_071300.1 ↔ LdBPK_271370.1 OG6 Tb927.11.2130 ↔ Tb927.8.570 OG6 TCSYLVIO_005523 ↔ TCSYLVIO_009688 OG7 LdBPK_071300.1 ↔ LdBPK_271370.1 +2 more	Both
C4B63_186g23 ⚠ ATP-dependent DEAD/H RNA helicase(fragment)	—	OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	OG7
C4B63_26g247 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_009688	Both
C4B63_80g10 ⚠ E3 ubiquitin-protein ligase HECTD3	—	OG6 TCSYLVIO_005364 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_005364 ↔ TCSYLVIO_009688	Both
C4B63_80g9 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005364 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_005364 ↔ TCSYLVIO_009688	Both
C4B63_4g531 Cleavage stimulation factor subunit 1	—	OG6 TCSYLVIO_005994 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_005994 ↔ TCSYLVIO_009688	Both
C4B63_259g8 ⚠ DNA polymerase theta (helicase domain only)	—	OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	OG7
C4B63_17g180 RNA-binding protein,	—	OG6 TCSYLVIO_004088 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_004088 ↔ TCSYLVIO_009688	Both
C4B63_7g432 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_007057 ↔ TCSYLVIO_009688	OG7
C4B63_16g132 ⚠ DNA polymerase theta (helicase domain only)	—	OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	OG7
C4B63_17g284 ⚠ ATP-dependent DNA DEAD/DEAH box helicase	—	OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	OG7
C4B63_26g248 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_009688	Both
C4B63_6g523 conserved hypothetical protein	—	OG6 Tb927.11.8310 ↔ Tb927.8.570 OG7 Tb927.11.8310 ↔ Tb927.8.570	Both
C4B63_127g51 acetyl-CoA carboxylase	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_009688	Both
C4B63_25g185 ⚠ ATP-dependent RNA helicase	—	OG6 TCSYLVIO_008995 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	Both
C4B63_51g90 ⚠ ATP-dependent RNA helicase	—	OG6 TCSYLVIO_008995 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_008995 ↔ TCSYLVIO_009688	Both
C4B63_2g154 ⚠ PRP8 protein homologue	—	OG6 TCSYLVIO_005762 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_005762 ↔ TCSYLVIO_009688	Both
C4B63_2g155 ⚠ PRP8 protein homologue	—	OG6 TCSYLVIO_005762 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_005762 ↔ TCSYLVIO_009688	Both
C4B63_25g112 kinesin	—	OG6 TCSYLVIO_009030 ↔ TCSYLVIO_009688	OG6
C4B63_69g30 Pre-mRNA-splicing factor U5-Cwc21	—	OG6 TCSYLVIO_003465 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_003465 ↔ TCSYLVIO_009688	Both
C4B63_35g173 proteasome 26S non-ATPase subunit 9	—	OG6 LdBPK_071300.1 ↔ LdBPK_160300.1 OG7 LdBPK_071300.1 ↔ LdBPK_160300.1	Both
C4B63_7g145 conserved hypothetical protein	—	OG6 TCSYLVIO_009688 ↔ TCSYLVIO_010962 OG7 TCSYLVIO_009688 ↔ TCSYLVIO_010962	Both