C4B63_112g19

proteasome beta 3 subunit

Trypanosoma cruzi Dm28c 2018 OG6: OG6_101970 OG7: OG7_0007205 38 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 38 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_43g129 ⚠ proteasome subunit alpha type-5	—	OG6 Tb927.10.230 ↔ Tb927.11.7270 OG6 LdBPK_212200.1 ↔ LdBPK_280110.1 OG7 Tb927.11.7020 ↔ Tb927.11.7270 OG7 Tb927.10.230 ↔ Tb927.11.7270 +18 more	Both
C4B63_43g135 ⚠ proteasome alpha 2 subunit	—	OG6 Tb927.10.290 ↔ Tb927.11.7270 OG6 LdBPK_212070.1 ↔ LdBPK_280110.1 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_009369 OG7 Tb927.11.7020 ↔ Tb927.11.7270 +19 more	Both
C4B63_2g692 ⚠ proteasome beta-1 subunit	—	OG6 LdBPK_280110.1 ↔ LdBPK_353880.1 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_005774 OG7 LdBPK_120030.1 ↔ LdBPK_280110.1 OG7 LdBPK_280110.1 ↔ LdBPK_353880.1 +5 more	Both
C4B63_48g135 ⚠ proteasome subunit alpha type-1	—	OG6 LdBPK_280110.1 ↔ LdBPK_361670.1 OG6 Tb11.v5.0196 ↔ Tb927.11.7270 OG6 Tb927.10.6030 ↔ Tb927.11.7270 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004937 +20 more	Both
C4B63_48g131 ⚠ proteasome subunit beta type-5	—	OG6 Tb927.10.6080 ↔ Tb927.11.7270 OG6 LdBPK_280110.1 ↔ LdBPK_361730.1 OG7 LdBPK_120030.1 ↔ LdBPK_280110.1 OG7 LdBPK_280110.1 ↔ LdBPK_353880.1 +5 more	Both
C4B63_70g80 ⚠ proteasome alpha 7 subunit	—	OG6 LdBPK_110240.1 ↔ LdBPK_280110.1 OG6 Tb927.11.7020 ↔ Tb927.11.7270 OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001736 OG7 Tb927.11.7020 ↔ Tb927.11.7270 +19 more	Both
C4B63_12g396 ⚠ proteasome alpha 7 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.3.780 OG6 LdBPK_270190.1 ↔ LdBPK_280110.1 OG7 Tb927.11.7020 ↔ Tb927.11.7270 OG7 Tb927.10.230 ↔ Tb927.11.7270 +18 more	Both
C4B63_89g44 ⚠ proteasome beta-1 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.6.1260 OG6 LdBPK_120030.1 ↔ LdBPK_280110.1 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_006999 OG7 LdBPK_120030.1 ↔ LdBPK_280110.1 +6 more	Both
C4B63_25g312 ⚠ proteasome alpha 3 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.7.4420 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_010341 OG6 LdBPK_140310.1 ↔ LdBPK_280110.1 OG7 Tb927.11.7020 ↔ Tb927.11.7270 +19 more	Both
C4B63_2g302 ⚠ proteasome alpha 1 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.9.9670 OG6 LdBPK_280110.1 ↔ LdBPK_354910.1 OG6 TCSYLVIO_001736 ↔ TCSYLVIO_005678 OG7 Tb927.11.7020 ↔ Tb927.11.7270 +19 more	Both
C4B63_6g586 proteasome beta 6 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.7.4790 OG6 LdBPK_060140.1 ↔ LdBPK_280110.1 OG7 Tb927.11.7270 ↔ Tb927.7.4790 OG7 LdBPK_060140.1 ↔ LdBPK_280110.1	Both
C4B63_13g138 proteasome subunit beta type-2	—	OG6 LdBPK_280110.1 ↔ LdBPK_360340.1 OG6 Tb927.10.4710 ↔ Tb927.11.7270 OG7 Tb927.10.4710 ↔ Tb927.11.7270 OG7 LdBPK_280110.1 ↔ LdBPK_360340.1	Both
C4B63_59g118 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004731	Both
C4B63_7g263 ribosomal RNA processing protein 6	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_003804	Both
C4B63_2g380 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004731	Both
C4B63_47g55 eukaryotic translation initiation factor 5	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004556	Both
C4B63_49g170 ⚠ ribosomal RNA processing protein 45	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
C4B63_23g275 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004479	Both
C4B63_47g105 ⚠ acetyltransferase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004519	Both
C4B63_20g197 ⚠ exosome-associated protein 2	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
C4B63_31g109 ⚠ ribose-phosphate pyrophosphokinase	—	OG7 TCSYLVIO_001736 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004731	OG7
C4B63_168g37 ⚠ T-complex protein 1, delta subunit	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_008271	OG6
C4B63_10g167 conserved hypothetical protein	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004312 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004312	Both
C4B63_52g137 conserved hypothetical protein	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_010606	Both
C4B63_57g94 ⚠ ATP-dependent RNA helicase	—	OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004479	OG7
C4B63_43g6 ⚠ T-complex protein 1, delta subunit	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_008271	OG6
C4B63_20g172 chaperonin alpha subunit	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_005312	OG6
C4B63_206g10 ⚠ acetyltransferase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004519	Both
C4B63_127g51 acetyl-CoA carboxylase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_002772 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_002772	Both
C4B63_14g147 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004731	Both
C4B63_2g66 helicase	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001736	OG6
C4B63_16g108 ⚠ chaperonin/T-complex protein 1 gamma subunit	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001736	OG6
C4B63_17g90 ⚠ T-complex protein 1, beta subunit	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001736	OG6
C4B63_70g86 conserved hypothetical protein	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_001736 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_001736	Both
C4B63_9g220 ⚠ Thioredoxin domain-containing protein PLP3A	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001736 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001736	Both
C4B63_80g17 ⚠ ATP binding protein-like protein	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001736 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001736	Both
C4B63_80g34 proteasome regulatory non-ATPase subunit 7	—	OG6 Tb927.11.16030 ↔ Tb927.11.7270 OG7 Tb927.11.16030 ↔ Tb927.11.7270	Both
C4B63_7g423 proteasome beta 7 subunit	—	OG6 Tb927.11.7270 ↔ Tb927.4.430 OG7 Tb927.11.7270 ↔ Tb927.4.430	Both