C4B63_48g131

proteasome subunit beta type-5

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100897 OG7: OG7_0001933 50 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 50 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_2g692 ⚠ proteasome beta-1 subunit	—	OG6 LdBPK_353880.1 ↔ LdBPK_361730.1 OG7 LdBPK_120030.1 ↔ LdBPK_353880.1 OG7 LdBPK_120030.1 ↔ LdBPK_361730.1 OG7 LdBPK_353880.1 ↔ LdBPK_361730.1 +2 more	Both
C4B63_43g135 ⚠ proteasome alpha 2 subunit	—	OG6 Tb927.10.290 ↔ Tb927.10.6080 OG6 LdBPK_212070.1 ↔ LdBPK_361730.1 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_48g135 ⚠ proteasome subunit alpha type-1	—	OG6 LdBPK_361670.1 ↔ LdBPK_361730.1 OG6 Tb11.v5.0196 ↔ Tb927.10.6080 OG6 Tb927.10.6030 ↔ Tb927.10.6080 OG7 Tb927.10.230 ↔ Tb927.10.6080 +44 more	Both
C4B63_112g19 ⚠ proteasome beta 3 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.11.7270 OG6 LdBPK_280110.1 ↔ LdBPK_361730.1 OG7 LdBPK_120030.1 ↔ LdBPK_280110.1 OG7 LdBPK_280110.1 ↔ LdBPK_353880.1 +5 more	Both
C4B63_12g396 ⚠ proteasome alpha 7 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.3.780 OG6 LdBPK_270190.1 ↔ LdBPK_361730.1 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_25g312 ⚠ proteasome alpha 3 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.7.4420 OG6 LdBPK_140310.1 ↔ LdBPK_361730.1 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_2g302 ⚠ proteasome alpha 1 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.9.9670 OG6 LdBPK_354910.1 ↔ LdBPK_361730.1 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_6g586 ⚠ proteasome beta 6 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.7.4790 OG6 LdBPK_060140.1 ↔ LdBPK_361730.1 OG7 TCSYLVIO_002482 ↔ TCSYLVIO_006999 OG7 LdBPK_060140.1 ↔ LdBPK_120030.1 +4 more	Both
C4B63_13g138 ⚠ proteasome subunit beta type-2	—	OG6 LdBPK_360340.1 ↔ LdBPK_361730.1 OG6 Tb927.10.4710 ↔ Tb927.10.6080 OG7 LdBPK_120030.1 ↔ LdBPK_360340.1 OG7 LdBPK_353880.1 ↔ LdBPK_360340.1 +4 more	Both
C4B63_89g44 ⚠ proteasome beta-1 subunit	—	OG6 LdBPK_120030.1 ↔ LdBPK_361730.1 OG6 Tb927.10.6080 ↔ Tb927.6.1260 OG7 LdBPK_120030.1 ↔ LdBPK_353880.1 OG7 LdBPK_120030.1 ↔ LdBPK_361730.1 +3 more	Both
C4B63_43g129 ⚠ proteasome subunit alpha type-5	—	OG6 Tb927.10.230 ↔ Tb927.10.6080 OG6 LdBPK_212200.1 ↔ LdBPK_361730.1 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_70g80 ⚠ proteasome alpha 7 subunit	—	OG6 LdBPK_110240.1 ↔ LdBPK_361730.1 OG6 Tb927.10.6080 ↔ Tb927.11.7020 OG7 Tb927.10.230 ↔ Tb927.10.6080 OG7 Tb927.10.290 ↔ Tb927.10.6080 +43 more	Both
C4B63_10g167 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_004312 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004312 ↔ TCSYLVIO_006999	OG7
C4B63_127g51 ⚠ acetyl-CoA carboxylase	—	OG7 TCSYLVIO_002772 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_006999	OG7
C4B63_47g105 ⚠ acetyltransferase	—	OG7 TCSYLVIO_004519 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004519 ↔ TCSYLVIO_006999	OG7
C4B63_57g94 ⚠ ATP-dependent RNA helicase	—	OG7 TCSYLVIO_004479 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004479 ↔ TCSYLVIO_006999	OG7
C4B63_7g263 ⚠ ribosomal RNA processing protein 6	—	OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_006999	OG7
C4B63_206g10 ⚠ acetyltransferase	—	OG7 TCSYLVIO_004519 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004519 ↔ TCSYLVIO_006999	OG7
C4B63_23g275 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG7 TCSYLVIO_004479 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004479 ↔ TCSYLVIO_006999	OG7
C4B63_59g118 ⚠ phosphoribosylpyrophosphate synthetase	—	OG7 TCSYLVIO_006999 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005774 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_006999	OG7
C4B63_14g147 ⚠ phosphoribosylpyrophosphate synthetase	—	OG7 TCSYLVIO_006999 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005774 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_006999	OG7
C4B63_4g478 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_004939 ↔ TCSYLVIO_010718	OG7
C4B63_31g109 ⚠ ribose-phosphate pyrophosphokinase	—	OG7 TCSYLVIO_006999 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005774 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_006999	OG7
C4B63_35g113 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_004939 ↔ TCSYLVIO_006469	OG7
C4B63_2g380 ⚠ phosphoribosylpyrophosphate synthetase	—	OG7 TCSYLVIO_006999 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005774 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004731 ↔ TCSYLVIO_006999	OG7
C4B63_52g137 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006999 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_005774 ↔ TCSYLVIO_010606	OG7
C4B63_47g55 ⚠ eukaryotic translation initiation factor 5	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_006999	OG7
C4B63_80g17 ⚠ ATP binding protein-like protein	—	OG7 TCSYLVIO_000453 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_006999	OG7
C4B63_9g220 ⚠ Thioredoxin domain-containing protein PLP3A	—	OG7 TCSYLVIO_000453 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_006999	OG7
C4B63_70g86 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001704 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_006999	OG7
C4B63_42g107 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_003184 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_003184 ↔ TCSYLVIO_004939	Both
C4B63_27g168 ⚠ flagellar pocket cytoskeletal protein bilbo1	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_006469 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_006469	Both
C4B63_32g250 ⚠ Peptidyl-prolyl cis-trans isomerase H	—	OG6 TCSYLVIO_001310 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001310 ↔ TCSYLVIO_004939	Both
C4B63_85g59 ⚠ pre-mRNA processing factor 3 (PRP3)	—	OG6 TCSYLVIO_003433 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_003433 ↔ TCSYLVIO_004939	Both
C4B63_20g44 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_003934 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_003934 ↔ TCSYLVIO_004939	Both
C4B63_80g34 ⚠ proteasome regulatory non-ATPase subunit 7	—	OG6 Tb927.10.6080 ↔ Tb927.11.16030 OG7 Tb927.10.6080 ↔ Tb927.11.16030	Both
C4B63_7g423 ⚠ proteasome beta 7 subunit	—	OG6 Tb927.10.6080 ↔ Tb927.4.430 OG7 Tb927.4.430 ↔ Tb927.6.1260 OG7 Tb927.10.6080 ↔ Tb927.4.430	Both
C4B63_49g170 ⚠ ribosomal RNA processing protein 45	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
C4B63_20g197 ⚠ exosome-associated protein 2	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
C4B63_87g42 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_009798 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_009798	Both
C4B63_232g18 ⚠ exosome complex exonuclease	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_010369 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_010369	Both
C4B63_79g28 ⚠ proteasome regulatory non-ATP-ase subunit 5	—	OG7 Tb927.10.1550 ↔ Tb927.6.1260	OG7
C4B63_31g60 ⚠ delta-adaptin	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_010530 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_010530	Both
C4B63_235g17 ⚠ paraflagellar rod component	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_006797 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_006797	Both
C4B63_10g507 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_010718 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_010718	Both
C4B63_1g39 ⚠ paraflagellar rod component	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_006797 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_006797	Both
C4B63_19g76 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004939 ↔ TCSYLVIO_007412 OG7 TCSYLVIO_004939 ↔ TCSYLVIO_007412	Both
C4B63_8g50 ⚠ mitochondrial RNA binding complex 1 subunit	—	OG6 TCSYLVIO_002300 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_002300 ↔ TCSYLVIO_004939	Both
C4B63_7g234 ⚠ Signal recognition particle subunit SRP68	—	OG6 TCSYLVIO_003828 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_003828 ↔ TCSYLVIO_004939	Both
C4B63_79g26 ⚠ proteasome regulatory non-ATP-ase subunit 5	—	OG7 Tb927.10.1550 ↔ Tb927.6.1260	OG7