C4B63_20g197

exosome-associated protein 2

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100420 OG7: OG7_0002825 69 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 69 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_232g18 ⚠ exosome complex exonuclease	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010369 OG6 Tb927.6.670 ↔ Tb927.7.4670 OG6 Tb927.11.16600 ↔ Tb927.7.4670 OG6 LdBPK_140010.1 ↔ LdBPK_221430.1 +4 more	Both
C4B63_34g374 ⚠ ribosomal RNA processing protein 41B	—	OG6 LdBPK_020290.1 ↔ LdBPK_221430.1 OG6 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 +2 more	Both
C4B63_173g5 ⚠ ribosomal RNA processing protein 41B	—	OG6 LdBPK_020290.1 ↔ LdBPK_221430.1 OG6 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 +2 more	Both
C4B63_72g94 ⚠ ribosomal RNA processing protein 40	—	OG6 LdBPK_040130.1 ↔ LdBPK_221430.1 OG6 Tb927.6.670 ↔ Tb927.9.7070 OG6 Tb927.11.16600 ↔ Tb927.9.7070 OG7 Tb927.6.670 ↔ Tb927.9.7070 +2 more	Both
C4B63_7g263 ⚠ ribosomal RNA processing protein 6	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
C4B63_40g162 ⚠ exosome-associated protein 4	—	OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 LdBPK_020290.1 ↔ LdBPK_221430.1	OG7
C4B63_57g92 ⚠ Ribosomal RNA processing protein 41A	—	OG6 Tb927.10.7450 ↔ Tb927.6.670 OG6 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 +2 more	Both
C4B63_52g137 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010606	Both
C4B63_48g159 ⚠ 25 kDa translation elongation factor 1-beta	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
C4B63_20g319 ⚠ 25 kDa translation elongation factor 1-beta	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
C4B63_112g19 ⚠ proteasome beta 3 subunit	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
C4B63_2g66 ⚠ helicase	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001893	OG6
C4B63_16g108 ⚠ chaperonin/T-complex protein 1 gamma subunit	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG6
C4B63_17g90 ⚠ T-complex protein 1, beta subunit	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG6
C4B63_10g167 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004312	Both
C4B63_23g275 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	Both
C4B63_168g37 ⚠ T-complex protein 1, delta subunit	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_008271	OG6
C4B63_47g105 ⚠ acetyltransferase	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004519	Both
C4B63_20g44 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003934 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003934	Both
C4B63_19g76 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_007412 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_007412	Both
C4B63_2g380 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
C4B63_49g170 ⚠ ribosomal RNA processing protein 45	—	OG6 Tb927.11.16600 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.6.670	Both
C4B63_16g154 ⚠ exosome component CSL4	—	OG6 Tb927.11.16600 ↔ Tb927.5.1200 OG6 Tb927.5.1200 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.5.1200 OG7 Tb927.5.1200 ↔ Tb927.6.670	Both
C4B63_70g80 ⚠ proteasome alpha 7 subunit	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
C4B63_44g250 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
C4B63_279g6 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
C4B63_8g521 ⚠ GPN-loop GTPase 2	—	OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	OG7
C4B63_194g21 ⚠ DNA-directed RNA polymerase III	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
C4B63_279g5 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
C4B63_57g94 ⚠ ATP-dependent RNA helicase	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	OG7
C4B63_48g135 ⚠ proteasome subunit alpha type-1	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
C4B63_43g129 ⚠ proteasome subunit alpha type-5	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
C4B63_25g312 ⚠ proteasome alpha 3 subunit	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
C4B63_4g478 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	OG7
C4B63_31g109 ⚠ ribose-phosphate pyrophosphokinase	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
C4B63_12g396 ⚠ proteasome alpha 7 subunit	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
C4B63_35g113 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	OG7
C4B63_27g168 ⚠ flagellar pocket cytoskeletal protein bilbo1	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006469 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	Both
C4B63_32g250 ⚠ Peptidyl-prolyl cis-trans isomerase H	—	OG6 TCSYLVIO_001310 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001310 ↔ TCSYLVIO_001893	Both
C4B63_97g18 ⚠ heat shock protein 110	—	OG6 Tb927.10.12710 ↔ Tb927.6.670	OG6
C4B63_80g17 ⚠ ATP binding protein-like protein	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001893	Both
C4B63_9g220 ⚠ Thioredoxin domain-containing protein PLP3A	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_001893	Both
C4B63_22g174 ⚠ exosome-associated protein 1	—	OG6 Tb927.1.2580 ↔ Tb927.6.670 OG6 Tb927.1.2580 ↔ Tb927.11.16600 OG7 Tb927.1.2580 ↔ Tb927.6.670 OG7 Tb927.1.2580 ↔ Tb927.11.16600	Both
C4B63_19g82 ⚠ RNA polymerase I second largest subunit	—	OG6 Tb927.11.630 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	Both
C4B63_70g86 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_001893	Both
C4B63_267g18 ⚠ conserved hypothetical protein	—	OG6 Tb927.3.1300 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.3.1300 ↔ Tb927.6.670	Both
C4B63_12g318 ⚠ conserved hypothetical protein	—	OG6 Tb927.3.1300 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.11.16600 ↔ Tb927.3.1300 OG7 Tb927.3.1300 ↔ Tb927.6.670	Both
C4B63_12g298 ⚠ GPN-loop GTPase 3	—	OG6 Tb927.3.1150 ↔ Tb927.6.670 OG6 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	Both
C4B63_14g147 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
C4B63_8g50 ⚠ mitochondrial RNA binding complex 1 subunit	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_002300 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_002300	Both

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