C4B63_72g94

ribosomal RNA processing protein 40
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102463 OG7: OG7_0007513 182 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 182 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_49g170 ⚠
ribosomal RNA processing protein 45
— +2 more Both
C4B63_20g197 ⚠
exosome-associated protein 2
— +2 more Both
C4B63_19g82 ⚠
RNA polymerase I second largest subunit
— Both
C4B63_22g174
exosome-associated protein 1
— Both
C4B63_16g154
exosome component CSL4
— Both
C4B63_34g374 ⚠
ribosomal RNA processing protein 41B
— Both
C4B63_173g5 ⚠
ribosomal RNA processing protein 41B
— Both
C4B63_232g18
exosome complex exonuclease
— Both
C4B63_57g92 ⚠
Ribosomal RNA processing protein 41A
— Both
C4B63_40g162 ⚠
exosome-associated protein 4
— OG7
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_279g6 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_17g284 ⚠
ATP-dependent DNA DEAD/DEAH box helicase
— OG7
C4B63_40g87
WD40 repeat-containing protein
— Both
C4B63_81g97
conserved hypothetical protein
— Both
C4B63_192g23 ⚠
conserved hypothetical protein
— Both
C4B63_267g12 ⚠
conserved hypothetical protein
— Both
C4B63_16g21 ⚠
conserved hypothetical protein
— Both
C4B63_49g173 ⚠
conserved hypothetical protein
— Both
C4B63_354g8 ⚠
damage-specific DNA binding protein
— Both
C4B63_45g105 ⚠
DNA polymerase sigma
— Both
C4B63_23g29
RNA-binding protein
— Both
C4B63_12g234 ⚠
protein transport protein Sec31
— Both
C4B63_267g18 ⚠
conserved hypothetical protein
— Both
C4B63_12g318 ⚠
conserved hypothetical protein
— Both
C4B63_12g298 ⚠
GPN-loop GTPase 3
— Both
C4B63_323g12 ⚠
protein kinase
— OG6
C4B63_23g3 ⚠
protein kinase
— OG6
C4B63_156g10 ⚠
protein kinase
— OG6
C4B63_20g319 ⚠
25 kDa translation elongation factor 1-beta
— Both
C4B63_48g159 ⚠
25 kDa translation elongation factor 1-beta
— Both
C4B63_8g521 ⚠
GPN-loop GTPase 2
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_4g2794c ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_21g86
conserved hypothetical protein
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_9g329 ⚠
Beige/BEACH domain
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_9g327 ⚠
conserved hypothetical protein
— OG7
C4B63_249g22 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— OG7
C4B63_304g10 ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_8g44
conserved hypothetical protein
— OG7
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.