C4B63_48g159

25 kDa translation elongation factor 1-beta

Trypanosoma cruzi Dm28c 2018 OG6: OG6_101695 OG7: OG7_0003992 74 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 74 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_20g319 ⚠ 25 kDa translation elongation factor 1-beta	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
C4B63_24g272 ⚠ Zn-finger in Ran binding protein and others/S	—	OG6 LdBPK_262390.1 ↔ LdBPK_361490.1 OG6 LdBPK_262390.1 ↔ LdBPK_340870.1 OG7 LdBPK_262390.1 ↔ LdBPK_361490.1 OG7 LdBPK_262390.1 ↔ LdBPK_340870.1	Both
C4B63_34g374 ⚠ ribosomal RNA processing protein 41B	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
C4B63_8g521 ⚠ GPN-loop GTPase 2	—	OG7 Tb927.10.5840 ↔ Tb927.3.1150	OG7
C4B63_279g6 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
C4B63_44g250 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
C4B63_11g83 ⚠ Eukaryotic translation initiation factor 3 su	—	OG6 LdBPK_251670.1 ↔ LdBPK_361490.1 OG6 LdBPK_251670.1 ↔ LdBPK_340870.1 OG7 LdBPK_251670.1 ↔ LdBPK_361490.1 OG7 LdBPK_251670.1 ↔ LdBPK_340870.1	Both
C4B63_24g273 ⚠ Probable E3 ubiquitin-protein ligase HERC1	—	OG6 LdBPK_262390.1 ↔ LdBPK_361490.1 OG6 LdBPK_262390.1 ↔ LdBPK_340870.1 OG7 LdBPK_262390.1 ↔ LdBPK_361490.1 OG7 LdBPK_262390.1 ↔ LdBPK_340870.1	Both
C4B63_173g5 ⚠ ribosomal RNA processing protein 41B	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
C4B63_19g82 ⚠ RNA polymerase I second largest subunit	—	OG6 Tb927.10.5840 ↔ Tb927.11.630 OG7 Tb927.10.5840 ↔ Tb927.11.630	Both
C4B63_20g197 ⚠ exosome-associated protein 2	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
C4B63_57g92 ⚠ Ribosomal RNA processing protein 41A	—	OG6 Tb927.10.5840 ↔ Tb927.10.7450 OG7 Tb927.10.5840 ↔ Tb927.10.7450	Both
C4B63_49g170 ⚠ ribosomal RNA processing protein 45	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
C4B63_12g298 ⚠ GPN-loop GTPase 3	—	OG6 Tb927.10.5840 ↔ Tb927.3.1150 OG7 Tb927.10.5840 ↔ Tb927.3.1150	Both
C4B63_12g318 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.5840 ↔ Tb927.3.1300 OG7 Tb927.10.5840 ↔ Tb927.3.1300	Both
C4B63_20g211 ⚠ Telomerase Cajal body protein 1	—	OG6 Tb927.10.5840 ↔ Tb927.11.16490 OG6 Tb927.11.16490 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.11.16490 OG7 Tb927.11.16490 ↔ Tb927.4.3590	Both
C4B63_267g18 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.5840 ↔ Tb927.3.1300 OG7 Tb927.10.5840 ↔ Tb927.3.1300	Both
C4B63_72g94 ⚠ ribosomal RNA processing protein 40	—	OG6 Tb927.10.5840 ↔ Tb927.9.7070 OG7 Tb927.10.5840 ↔ Tb927.9.7070	Both
C4B63_7g55 ⚠ conserved hypothetical protein	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_95g43 ⚠ conserved hypothetical protein	—	OG7 LdBPK_130700.1 ↔ LdBPK_361490.1 OG7 LdBPK_130700.1 ↔ LdBPK_340870.1	OG7
C4B63_26g206 ⚠ glutaminyl-tRNA synthetase	—	OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	OG7
C4B63_54g50 ⚠ conserved hypothetical protein	—	OG7 LdBPK_350610.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_350610.1	OG7
C4B63_11g90 ⚠ conserved hypothetical protein	—	OG7 LdBPK_251630.1 ↔ LdBPK_361490.1 OG7 LdBPK_251630.1 ↔ LdBPK_340870.1	OG7
C4B63_122g17 ⚠ conserved hypothetical protein	—	OG7 LdBPK_090810.1 ↔ LdBPK_361490.1 OG7 LdBPK_090810.1 ↔ LdBPK_340870.1	OG7
C4B63_87g20 ⚠ Brefeldin A-inhibited guanine nucleotide-exch	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_7g57 ⚠ Brefeldin A-inhibited guanine nucleotide-exch	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_87g21 ⚠ conserved hypothetical protein	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_16g154 ⚠ exosome component CSL4	—	OG6 Tb927.10.5840 ↔ Tb927.5.1200 OG7 Tb927.10.5840 ↔ Tb927.5.1200	Both
C4B63_81g14 ⚠ guanine-nucleotide exchange factor, Sec7	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_7g56 ⚠ Protein transport protein sec71	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_81g15 ⚠ guanine-nucleotide exchange factor, Sec7	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
C4B63_279g5 ⚠ DNA-directed RNA polymerase II subunit 2	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
C4B63_194g21 ⚠ DNA-directed RNA polymerase III	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
C4B63_40g162 ⚠ exosome-associated protein 4	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
C4B63_18g223 ⚠ eukaryotic translation initiation factor 3 su	—	OG6 LdBPK_303080.1 ↔ LdBPK_361490.1 OG6 LdBPK_303080.1 ↔ LdBPK_340870.1 OG7 LdBPK_303080.1 ↔ LdBPK_361490.1 OG7 LdBPK_303080.1 ↔ LdBPK_340870.1	Both
C4B63_263g3 ⚠ conserved hypothetical protein	—	OG6 LdBPK_340870.1 ↔ LdBPK_343240.1 OG6 LdBPK_343240.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_343240.1 OG7 LdBPK_343240.1 ↔ LdBPK_361490.1	Both
C4B63_286g21 ⚠ conserved hypothetical protein	—	OG6 LdBPK_340870.1 ↔ LdBPK_367300.1 OG6 LdBPK_361490.1 ↔ LdBPK_367300.1 OG7 LdBPK_340870.1 ↔ LdBPK_367300.1 OG7 LdBPK_361490.1 ↔ LdBPK_367300.1	Both
C4B63_63g45 ⚠ methyltransferase	—	OG6 Tb927.10.7940 ↔ Tb927.4.3590 OG6 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.7940 ↔ Tb927.4.3590	Both
C4B63_22g93 ⚠ transmembrane protein, conserved	—	OG6 LdBPK_200940.1 ↔ LdBPK_361490.1 OG6 LdBPK_200940.1 ↔ LdBPK_340870.1 OG7 LdBPK_200940.1 ↔ LdBPK_361490.1 OG7 LdBPK_200940.1 ↔ LdBPK_340870.1	Both
C4B63_2g411 ⚠ conserved hypothetical protein	—	OG6 LdBPK_332380.1 ↔ LdBPK_361490.1 OG6 LdBPK_332380.1 ↔ LdBPK_340870.1 OG7 LdBPK_332380.1 ↔ LdBPK_361490.1 OG7 LdBPK_332380.1 ↔ LdBPK_340870.1	Both
C4B63_7g68 ⚠ Brefeldin A-inhibited guanine nucleotide-exch	—	OG6 LdBPK_342220.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_342220.1 OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	Both
C4B63_7g67 ⚠ Sec7 guanine-nucleotide exchange factor	—	OG6 LdBPK_342220.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_342220.1 OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	Both
C4B63_22g174 ⚠ exosome-associated protein 1	—	OG6 Tb927.1.2580 ↔ Tb927.10.5840 OG7 Tb927.1.2580 ↔ Tb927.10.5840	Both
C4B63_7g312 ⚠ conserved hypothetical protein	—	OG6 LdBPK_340870.1 ↔ LdBPK_343240.1 OG6 LdBPK_343240.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_343240.1 OG7 LdBPK_343240.1 ↔ LdBPK_361490.1	Both
C4B63_11g87 ⚠ conserved hypothetical protein	—	OG6 LdBPK_251630.1 ↔ LdBPK_361490.1 OG6 LdBPK_251630.1 ↔ LdBPK_340870.1 OG7 LdBPK_251630.1 ↔ LdBPK_361490.1 OG7 LdBPK_251630.1 ↔ LdBPK_340870.1	Both
C4B63_11g89 ⚠ TRAPPC8	—	OG6 LdBPK_251630.1 ↔ LdBPK_361490.1 OG6 LdBPK_251630.1 ↔ LdBPK_340870.1 OG7 LdBPK_251630.1 ↔ LdBPK_361490.1 OG7 LdBPK_251630.1 ↔ LdBPK_340870.1	Both

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