C4B63_45g105

DNA polymerase sigma
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101092 OG7: OG7_0003906 64 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 64 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_18g156 ⚠
protein mkt1
— OG7
C4B63_304g10 ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_44g118 ⚠
conserved hypothetical protein
— OG7
C4B63_2g336 ⚠
Proteinaceous RNase P 2
— OG7
C4B63_80g31 ⚠
Dynein assembly factor 4, axonemal
— OG7
C4B63_79g89 ⚠
RNA helicase
— OG7
C4B63_14g87 ⚠
conserved hypothetical protein
— OG7
C4B63_2g735 ⚠
acyl transferase-like protein
— OG7
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_2g61 ⚠
conserved hypothetical protein
— OG7
C4B63_2g60 ⚠
conserved hypothetical protein
— OG7
C4B63_93g92 ⚠
Myotubularin-related protein
— OG7
C4B63_2g382 ⚠
Proteinaceous RNase P 2
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_41g138 ⚠
myotubularin
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_31g100 ⚠
conserved hypothetical protein
— OG7
C4B63_7g95 ⚠
conserved hypothetical protein
— OG7
C4B63_8g496 ⚠
conserved hypothetical protein
— OG7
C4B63_7g395 ⚠
conserved hypothetical protein
— OG7
C4B63_38g75 ⚠
conserved hypothetical protein
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_2g736 ⚠
acyl transferase-like protein
— OG7
C4B63_104g76 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_104g75 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_55g67 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_31g115 ⚠
eukaryotic translation initiation factor 2 be
— OG7
C4B63_323g12 ⚠
protein kinase
— OG6
C4B63_55g168 ⚠
Cilia- and flagella-associated protein 57
— Both
C4B63_45g218 ⚠
conserved hypothetical protein
— Both
C4B63_45g216 ⚠
conserved hypothetical protein
— Both
C4B63_45g217 ⚠
WD40 repeat protein
— Both
C4B63_40g114 ⚠
glycosyl hydrolase
— Both
C4B63_49g174 ⚠
conserved hypothetical protein
— Both
C4B63_40g80 ⚠
DNA-directed RNA polymerase I subunit
— Both
C4B63_8g513 ⚠
conserved hypothetical protein
— Both
C4B63_54g15 ⚠
Fatty acid oxidation complex subunit alpha
— Both
C4B63_79g39 ⚠
conserved hypothetical protein
— Both
C4B63_44g149 ⚠
conserved hypothetical protein
— Both
C4B63_53g162 ⚠
conserved hypothetical protein
— Both
C4B63_42g82
RNA-binding protein
— OG6
C4B63_49g173 ⚠
conserved hypothetical protein
— Both
C4B63_22g174 ⚠
exosome-associated protein 1
— Both
C4B63_72g94 ⚠
ribosomal RNA processing protein 40
— Both
C4B63_23g3 ⚠
protein kinase
— OG6
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.