LAEL147_000037800

delta-1-pyrroline-5-carboxylate dehydrogenase, putative

Leishmania aethiopica L147 OG6: OG6_102275 OG7: OG7_0000710 40 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 40 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000442800 cytochrome c oxidase subunit V, putative	—	OG6 Tb927.10.3210 ↔ Tb927.9.3170 OG7 Tb927.10.3210 ↔ Tb927.9.3170	Both
LAEL147_000106200 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
LAEL147_000851800 S-adenosylhomocysteine hydrolase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
LAEL147_000354700 (H+)-ATPase G subunit, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both
LAEL147_000756200 vacuolar ATP synthase subunit d, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.3760 OG7 Tb927.10.3210 ↔ Tb927.10.3760	Both
LAEL147_000842900 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9420 OG7 Tb927.10.3210 ↔ Tb927.11.9420	Both
LAEL147_000868200 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
LAEL147_000740900 vacuolar ATP synthase catalytic subunit A, pu	—	OG6 Tb927.10.3210 ↔ Tb927.4.1080 OG7 Tb927.10.3210 ↔ Tb927.4.1080	Both
LAEL147_000350900 ⚠ peroxidoxin	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LAEL147_000152600 3-methylcrotonoyl-CoA carboxylase beta subuni	—	OG6 Tb927.10.3210 ↔ Tb927.11.6630 OG7 Tb927.10.3210 ↔ Tb927.11.6630	Both
LAEL147_000219200 ⚠ C-terminal domain of 1-Cys peroxiredoxin, put	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LAEL147_000508100 vacuolar ATP synthase subunit b, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both
LAEL147_000219400 ⚠ C-terminal domain of 1-Cys peroxiredoxin, put	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LAEL147_000686900 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
LAEL147_000339900 Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
LAEL147_000168300 vacuolar ATP synthase subunit, putative	—	OG6 Tb927.1.3820 ↔ Tb927.10.3210 OG7 Tb927.1.3820 ↔ Tb927.10.3210	Both
LAEL147_000314300 ⚠ Hexokinase, putative	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
LAEL147_000314200 ⚠ hexokinase, putative	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
LAEL147_000027000 ⚠ hypothetical protein	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LAEL147_000884300 ⚠ prolyl oligopeptidase, putative	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LAEL147_000619600 ⚠ hypothetical protein	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
LAEL147_000753000 hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
LAEL147_000075300 ⚠ serine peptidase, clan SC, family S9A-like pr	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
LAEL147_000784000 Peroxin 19	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
LAEL147_000758400 hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005125	Both
LAEL147_000706000 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
LAEL147_000075700 ⚠ serine peptidase, clan SC, family S9A-like pr	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
LAEL147_000851100 glycyl tRNA synthetase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_009222 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_009222	Both
LAEL147_000579900 valyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
LAEL147_000619700 ⚠ phosphoglycan beta 1,3 galactosyltransferase	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
LAEL147_000295200 ⚠ deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
LAEL147_000183200 leucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
LAEL147_000583100 T-complex protein 11, putative	—	OG6 TCSYLVIO_003373 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003373 ↔ TCSYLVIO_004515	Both
LAEL147_000542700 serine/threonine-protein kinase, putative	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
LAEL147_000749800 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 Tb927.10.3210 ↔ Tb927.10.4330 OG7 Tb927.10.3210 ↔ Tb927.10.4330	Both
LAEL147_000111300 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
LAEL147_000157200 pyruvate phosphate dikinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.6280 OG7 Tb927.10.3210 ↔ Tb927.11.6280	Both
LAEL147_000618400 acetyl-CoA carboxylase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
LAEL147_000219300 ⚠ AhpC/TSA family/C-terminal domain of 1-Cys pe	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LAEL147_000327700 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.730 OG7 Tb927.10.3210 ↔ Tb927.10.730	Both