LAEL147_000357000

acetyl-CoA synthetase, putative

Leishmania aethiopica L147 OG6: OG6_100430 OG7: OG7_0000501 48 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 48 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000848300 ⚠ cysteine synthase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_008128	Both
LAEL147_000244000 ⚠ cystathionine beta-synthase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
LAEL147_000438100 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	Both
LAEL147_000356100 ⚠ trypanothione synthetase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000381400 ⚠ malic enzyme, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
LAEL147_000474000 ⚠ paraflagellar rod protein-like protein	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000425 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	Both
LAEL147_000264900 ⚠ citrate synthase, putative	—	OG6 LdBPK_180700.1 ↔ LdBPK_230580.1 OG6 LdBPK_180700.1 ↔ LdBPK_230880.1 OG7 LdBPK_180700.1 ↔ LdBPK_230580.1 OG7 LdBPK_180700.1 ↔ LdBPK_230880.1	Both
LAEL147_000500400 ⚠ NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
LAEL147_000446300 ⚠ Methyltransferase domain containing protein,	—	OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	OG7
LAEL147_000415800 ⚠ PUA domain/NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
LAEL147_000720300 ⚠ Protein of unknown function (DUF3808), putati	—	OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	OG7
LAEL147_000536700 ⚠ NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
LAEL147_000588200 ⚠ nucleolar protein, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
LAEL147_000697300 ⚠ D-alanyl-glycyl endopeptidase-like protein	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000534100 ⚠ paraflagellar rod protein 1D, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
LAEL147_000869600 ⚠ aminopeptidase P1, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	OG7
LAEL147_000434600 ⚠ heat shock 70 protein-like protein	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG7
LAEL147_000425400 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000425500 ⚠ hypothetical protein	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000696900 ⚠ D-alanyl-glycyl endopeptidase-like protein	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000425300 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
LAEL147_000271700 ⚠ heat shock protein 110, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG7
LAEL147_000025300 ⚠ HSP70-like protein	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG7
LAEL147_000799400 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG7
LAEL147_000534000 ⚠ paraflagellar rod protein 1D, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
LAEL147_000702100 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_230880.1 ↔ LdBPK_333400.1 OG7 LdBPK_230880.1 ↔ LdBPK_333400.1	Both
LAEL147_000061500 ⚠ dual specificity phosphatase-like protein	—	OG6 LdBPK_050220.1 ↔ LdBPK_230880.1	OG6
LAEL147_000061300 ⚠ dual specificity phosphatase-like protein	—	OG6 LdBPK_050220.1 ↔ LdBPK_230880.1	OG6
LAEL147_000110500 ⚠ DnaJ domain containing protein, putative	—	OG6 LdBPK_080930.1 ↔ LdBPK_230880.1 OG7 LdBPK_080930.1 ↔ LdBPK_230880.1	Both
LAEL147_000361400 ⚠ acetyl-CoA synthetase, putative	—	OG6 LdBPK_230580.1 ↔ LdBPK_230880.1 OG7 LdBPK_230580.1 ↔ LdBPK_230880.1	Both
LAEL147_000582000 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_230880.1 ↔ LdBPK_303370.1 OG7 LdBPK_230880.1 ↔ LdBPK_303370.1	Both
LAEL147_000792600 ⚠ kinetoplastid kinetochore protein 3, putative	—	OG6 LdBPK_230880.1 ↔ LdBPK_354110.1 OG7 LdBPK_230880.1 ↔ LdBPK_354110.1	Both
LAEL147_000586200 ⚠ 5-methyltetrahydropteroyltriglutamate-homocys	—	OG6 LdBPK_230880.1 ↔ LdBPK_310010.1 OG7 LdBPK_230880.1 ↔ LdBPK_310010.1	Both
LAEL147_000647400 ⚠ NOL1/NOP2/sun family, putative	—	OG6 LdBPK_230580.1 ↔ LdBPK_322580.1 OG6 LdBPK_230880.1 ↔ LdBPK_322580.1 OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	Both
LAEL147_000525100 ⚠ 5-histidylcysteine sulfoxide synthase, putati	—	OG6 LdBPK_230580.1 ↔ LdBPK_291030.1 OG6 LdBPK_230880.1 ↔ LdBPK_291030.1 OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	Both
LAEL147_000886800 ⚠ elks delta-like protein	—	OG6 LdBPK_230580.1 ↔ LdBPK_367300.1 OG6 LdBPK_230880.1 ↔ LdBPK_367300.1 OG7 LdBPK_230580.1 ↔ LdBPK_367300.1 OG7 LdBPK_230880.1 ↔ LdBPK_367300.1	Both
LAEL147_000585500 ⚠ Protein of unknown function (DUF3808), putati	—	OG6 LdBPK_230580.1 ↔ LdBPK_303750.1 OG6 LdBPK_230880.1 ↔ LdBPK_303750.1 OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	Both
LAEL147_000524000 ⚠ guanine deaminase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_007737 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_007737	Both
LAEL147_000719000 ⚠ d-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
LAEL147_000719100 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 LdBPK_044360.1 ↔ LdBPK_230580.1 OG6 LdBPK_044360.1 ↔ LdBPK_230880.1 OG7 LdBPK_044360.1 ↔ LdBPK_230580.1 OG7 LdBPK_044360.1 ↔ LdBPK_230880.1	Both
LAEL147_000381500 ⚠ malic enzyme, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
LAEL147_000474200 ⚠ trypanothione synthetase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000427 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	Both
LAEL147_000511600 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	Both
LAEL147_000494700 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	Both
LAEL147_000433800 ⚠ aspartate--ammonia ligase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002332 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002332	Both
LAEL147_000773800 ⚠ aminopeptidase P, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
LAEL147_000512000 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
LAEL147_000511500 ⚠ Hsp70 protein, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002194	Both