LAEL147_000381400

malic enzyme, putative

Leishmania aethiopica L147 OG6: OG6_100205 OG7: OG7_0002857 56 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 56 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000356100 ⚠ trypanothione synthetase, putative	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000361400 ⚠ acetyl-CoA synthetase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
LAEL147_000357000 ⚠ acetyl-CoA synthetase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
LAEL147_000619700 ⚠ phosphoglycan beta 1,3 galactosyltransferase	—	OG6 LdBPK_240780.1 ↔ LdBPK_313210.1 OG7 LdBPK_240780.1 ↔ LdBPK_313210.1	Both
LAEL147_000619600 ⚠ hypothetical protein	—	OG6 LdBPK_240780.1 ↔ LdBPK_313210.1 OG7 LdBPK_240780.1 ↔ LdBPK_313210.1	Both
LAEL147_000564300 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_240780.1 ↔ LdBPK_301690.1 OG7 LdBPK_240780.1 ↔ LdBPK_301690.1	Both
LAEL147_000668100 ⚠ ATP-binding cassette sub-family F member 1, p	—	OG6 LdBPK_240780.1 ↔ LdBPK_330340.1 OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	Both
LAEL147_000474200 ⚠ trypanothione synthetase, putative	—	OG6 TCSYLVIO_000427 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	Both
LAEL147_000883100 ⚠ 2,3-bisphosphoglycerate-independent phosphogl	—	OG6 Tb927.10.7930 ↔ Tb927.11.5450 OG7 Tb927.10.7930 ↔ Tb927.11.5450	Both
LAEL147_000697300 ⚠ D-alanyl-glycyl endopeptidase-like protein	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000425400 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000425500 ⚠ hypothetical protein	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000696900 ⚠ D-alanyl-glycyl endopeptidase-like protein	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000425300 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000427 ↔ TCSYLVIO_001501	OG7
LAEL147_000169300 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.11.5450 OG6 Tb927.1.3950 ↔ Tb927.11.5440 OG7 Tb927.1.3950 ↔ Tb927.11.5450 OG7 Tb927.1.3950 ↔ Tb927.11.5440	Both
LAEL147_000434600 ⚠ heat shock 70 protein-like protein	—	OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	OG7
LAEL147_000152900 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	OG7
LAEL147_000153000 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	OG7
LAEL147_000271700 ⚠ heat shock protein 110, putative	—	OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	OG7
LAEL147_000025300 ⚠ HSP70-like protein	—	OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	OG7
LAEL147_000799400 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	OG7
LAEL147_000534100 ⚠ paraflagellar rod protein 1D, putative	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
LAEL147_000534000 ⚠ paraflagellar rod protein 1D, putative	—	OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	OG7
LAEL147_000869600 ⚠ aminopeptidase P1, putative	—	OG7 TCSYLVIO_001380 ↔ TCSYLVIO_001501	OG7
LAEL147_000421800 ⚠ elongation factor 2-like protein	—	OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	OG7
LAEL147_000644700 ⚠ small nuclear ribonucleoprotein component-lik	—	OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	OG7
LAEL147_000037400 ⚠ ATP-binding cassette protein subfamily F, mem	—	OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	OG7
LAEL147_000283400 ⚠ ABC transport system ATP-binding protein, put	—	OG7 LdBPK_240780.1 ↔ LdBPK_330340.1	OG7
LAEL147_000809200 ⚠ small GTP-binding protein domain containing p	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
LAEL147_000422400 ⚠ succinyl-CoA synthetase alpha subunit, putati	—	OG6 Tb927.11.5450 ↔ Tb927.3.2230 OG7 Tb927.11.5450 ↔ Tb927.3.2230	Both
LAEL147_000784800 ⚠ 6-phosphogluconate dehydrogenase, decarboxyla	—	OG6 Tb927.11.5440 ↔ Tb927.9.12110 OG6 Tb927.11.5450 ↔ Tb927.9.12110 OG7 Tb927.11.5440 ↔ Tb927.9.12110 OG7 Tb927.11.5450 ↔ Tb927.9.12110	Both
LAEL147_000264900 ⚠ citrate synthase, putative	—	OG6 Tb927.10.13430 ↔ Tb927.11.5450 OG6 Tb927.10.13430 ↔ Tb927.11.5440 OG7 Tb927.10.13430 ↔ Tb927.11.5450 OG7 Tb927.10.13430 ↔ Tb927.11.5440	Both
LAEL147_000422500 ⚠ succinyl-CoA synthetase alpha subunit, putati	—	OG6 Tb927.11.5450 ↔ Tb927.3.2230 OG7 Tb927.11.5450 ↔ Tb927.3.2230	Both
LAEL147_000376600 ⚠ fumarate hydratase, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
LAEL147_000536200 ⚠ fumarate hydratase, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
LAEL147_000133800 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 Tb927.11.5440 ↔ Tb927.8.3690 OG6 Tb927.11.5440 ↔ Tb927.11.900 OG6 Tb927.11.5450 ↔ Tb927.11.900 OG7 Tb927.11.5440 ↔ Tb927.8.3690 +2 more	Both
LAEL147_000056400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_041000.1 ↔ LdBPK_240780.1 OG7 LdBPK_041000.1 ↔ LdBPK_240780.1	Both
LAEL147_000204000 ⚠ enolase	—	OG6 Tb927.10.2890 ↔ Tb927.11.5450 OG6 Tb927.10.2890 ↔ Tb927.11.5440 OG7 Tb927.10.2890 ↔ Tb927.11.5450 OG7 Tb927.10.2890 ↔ Tb927.11.5440	Both
LAEL147_000773800 ⚠ aminopeptidase P, putative	—	OG6 TCSYLVIO_001380 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_001380 ↔ TCSYLVIO_001501	Both
LAEL147_000474000 ⚠ paraflagellar rod protein-like protein	—	OG6 TCSYLVIO_000425 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000425 ↔ TCSYLVIO_001501	Both
LAEL147_000006700 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
LAEL147_000809100 ⚠ elongation factor 2	—	OG6 Tb927.10.4560 ↔ Tb927.11.5450 OG6 Tb927.10.4560 ↔ Tb927.11.5440 OG7 Tb927.10.4560 ↔ Tb927.11.5450 OG7 Tb927.10.4560 ↔ Tb927.11.5440	Both
LAEL147_000381500 ⚠ malic enzyme, putative	—	OG6 Tb927.11.5440 ↔ Tb927.11.5450 OG7 Tb927.11.5440 ↔ Tb927.11.5450	Both
LAEL147_000263400 ⚠ aconitase, putative	—	OG6 Tb927.10.14000 ↔ Tb927.11.5450 OG6 Tb927.10.14000 ↔ Tb927.11.5440 OG7 Tb927.10.14000 ↔ Tb927.11.5450 OG7 Tb927.10.14000 ↔ Tb927.11.5440	Both
LAEL147_000694000 ⚠ aminopeptidase, putative	—	OG6 TCSYLVIO_001500 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005560	Both
LAEL147_000784000 ⚠ Peroxin 19	—	OG6 TCSYLVIO_001500 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_001500 ↔ TCSYLVIO_005818	Both
LAEL147_000511600 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_001501 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	Both
LAEL147_000494700 ⚠ heat-shock protein hsp70, putative	—	OG6 TCSYLVIO_001501 ↔ TCSYLVIO_002194 OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002194	Both
LAEL147_000244000 ⚠ cystathionine beta-synthase	—	OG6 TCSYLVIO_001501 ↔ TCSYLVIO_008128	OG6
LAEL147_000433800 ⚠ aspartate--ammonia ligase, putative	—	OG6 TCSYLVIO_001501 ↔ TCSYLVIO_002332 OG7 TCSYLVIO_001501 ↔ TCSYLVIO_002332	Both

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