LAEL147_000376600

fumarate hydratase, putative

Leishmania aethiopica L147 OG6: OG6_102839 OG7: OG7_0008166 34 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 34 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000524000 ⚠ guanine deaminase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.5.4560 OG7 Tb927.3.4500 ↔ Tb927.5.4560	Both
LAEL147_000397000 ⚠ 3-hydroxy-3-methylglutaryl-CoA synthase, puta	—	OG6 Tb927.3.4500 ↔ Tb927.8.6110 OG6 Tb927.11.5050 ↔ Tb927.8.6110 OG7 Tb927.3.4500 ↔ Tb927.8.6110 OG7 Tb927.11.5050 ↔ Tb927.8.6110	Both
LAEL147_000274200 ⚠ nonspecific nucleoside hydrolase	—	OG6 Tb927.3.4500 ↔ Tb927.7.4570 OG7 Tb927.3.4500 ↔ Tb927.7.4570	Both
LAEL147_000050700 ⚠ adenylosuccinate lyase, putative	—	OG6 Tb927.11.5050 ↔ Tb927.9.7550 OG7 Tb927.11.5050 ↔ Tb927.9.7550	Both
LAEL147_000067200 ⚠ methylthioadenosine phosphorylase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.7.7040 OG6 Tb927.11.5050 ↔ Tb927.7.7040 OG7 Tb927.3.4500 ↔ Tb927.7.7040 OG7 Tb927.11.5050 ↔ Tb927.7.7040	Both
LAEL147_000784800 ⚠ 6-phosphogluconate dehydrogenase, decarboxyla	—	OG6 Tb927.11.5050 ↔ Tb927.9.12110 OG7 Tb927.11.5050 ↔ Tb927.9.12110	Both
LAEL147_000536200 ⚠ fumarate hydratase, putative	—	OG6 Tb927.11.5050 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.3.4500	Both
LAEL147_000538200 ⚠ C-8 sterol isomerase-like protein	—	OG6 Tb927.3.4500 ↔ Tb927.3.4650 OG7 Tb927.3.4500 ↔ Tb927.3.4650	Both
LAEL147_000396500 ⚠ transketolase	—	OG6 Tb927.3.4500 ↔ Tb927.8.6170 OG7 Tb927.3.4500 ↔ Tb927.8.6170	Both
LAEL147_000782100 ⚠ glycerol kinase, glycosomal, putative	—	OG6 Tb927.3.4500 ↔ Tb927.9.12570 OG6 Tb927.11.5050 ↔ Tb927.9.12570 OG7 Tb927.3.4500 ↔ Tb927.9.12570 OG7 Tb927.11.5050 ↔ Tb927.9.12570	Both
LAEL147_000218900 ⚠ glutamate dehydrogenase	—	OG6 Tb927.3.4500 ↔ Tb927.9.5900 OG7 Tb927.3.4500 ↔ Tb927.9.5900	Both
LAEL147_000191200 ⚠ inosine-guanine nucleoside hydrolase, putativ	—	OG6 Tb927.3.4500 ↔ Tb927.7.4570 OG7 Tb927.3.4500 ↔ Tb927.7.4570	Both
LAEL147_000799800 ⚠ glyceraldehyde-3-phosphate dehydrogenase-like	—	OG6 Tb927.3.4500 ↔ Tb927.9.9820 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LAEL147_000018300 ⚠ S-adenosylmethionine synthetase	—	OG6 Tb927.3.4500 ↔ Tb927.6.4840 OG7 Tb927.3.4500 ↔ Tb927.6.4840	Both
LAEL147_000011300 ⚠ S-adenosylmethionine synthetase	—	OG6 Tb927.3.4500 ↔ Tb927.6.4840 OG7 Tb927.3.4500 ↔ Tb927.6.4840	Both
LAEL147_000653300 ⚠ nucleoside diphosphate kinase b	—	OG6 Tb927.11.16130 ↔ Tb927.11.5050 OG6 Tb927.11.16130 ↔ Tb927.3.4500 OG7 Tb927.11.16130 ↔ Tb927.11.5050 OG7 Tb927.11.16130 ↔ Tb927.3.4500	Both
LAEL147_000865900 ⚠ aldehyde dehydrogenase, putative	—	OG7 Tb927.3.4500 ↔ Tb927.6.4210	OG7
LAEL147_000833700 ⚠ glyceraldehyde 3-phosphate dehydrogenase, cyt	—	OG6 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LAEL147_000381500 ⚠ malic enzyme, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
LAEL147_000264900 ⚠ citrate synthase, putative	—	OG6 Tb927.10.13430 ↔ Tb927.11.5050 OG7 Tb927.10.13430 ↔ Tb927.11.5050	Both
LAEL147_000381400 ⚠ malic enzyme, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
LAEL147_000783700 ⚠ cystathione gamma lyase, putative	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005821 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_005821	Both
LAEL147_000654600 ⚠ protein phosphatase 2A catalytic subunit, put	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005289	OG6
LAEL147_000510500 ⚠ protein phosphatase 4 catalytic subunit, puta	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005289	OG6
LAEL147_000826500 ⚠ aldehyde dehydrogenase, putative	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_004949 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_004949	Both
LAEL147_000195000 ⚠ cystathionine beta-lyase-like protein	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005821 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_005821	Both
LAEL147_000184200 ⚠ adenylosuccinate synthetase, putative	—	OG6 Tb927.11.3650 ↔ Tb927.3.4500 OG7 Tb927.11.3650 ↔ Tb927.3.4500	Both
LAEL147_000578000 ⚠ glyceraldehyde 3-phosphate dehydrogenase, gly	—	OG6 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LAEL147_000578100 ⚠ glyceraldehyde 3-phosphate dehydrogenase, gly	—	OG6 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LAEL147_000204000 ⚠ enolase	—	OG6 Tb927.10.2890 ↔ Tb927.11.5050 OG6 Tb927.10.2890 ↔ Tb927.3.4500 OG7 Tb927.10.2890 ↔ Tb927.11.5050 OG7 Tb927.10.2890 ↔ Tb927.3.4500	Both
LAEL147_000263400 ⚠ aconitase, putative	—	OG6 Tb927.10.14000 ↔ Tb927.11.5050 OG6 Tb927.10.14000 ↔ Tb927.3.4500 OG7 Tb927.10.14000 ↔ Tb927.11.5050 OG7 Tb927.10.14000 ↔ Tb927.3.4500	Both
LAEL147_000062900 ⚠ trypanothione reductase	—	OG6 Tb927.10.10390 ↔ Tb927.3.4500 OG7 Tb927.10.10390 ↔ Tb927.3.4500	Both
LAEL147_000169300 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.11.5050 OG6 Tb927.1.3950 ↔ Tb927.3.4500 OG7 Tb927.1.3950 ↔ Tb927.11.5050 OG7 Tb927.1.3950 ↔ Tb927.3.4500	Both
LAEL147_000577300 ⚠ aldehyde dehydrogenase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.6.4210 OG7 Tb927.3.4500 ↔ Tb927.6.4210	Both