LAEL147_000018300

S-adenosylmethionine synthetase
Leishmania aethiopica L147 OG6: OG6_100388 OG7: OG7_0003674 42 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 42 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAEL147_000376600 ⚠
fumarate hydratase, putative
— Both
LAEL147_000274200 ⚠
nonspecific nucleoside hydrolase
— Both
LAEL147_000245000 ⚠
Dihydrouridine synthase (Dus), putative
— Both
LAEL147_000023900 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LAEL147_000396500 ⚠
transketolase
— Both
LAEL147_000023600 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LAEL147_000222700 ⚠
glutaminyl-tRNA synthetase, putative
— Both
LAEL147_000191200 ⚠
inosine-guanine nucleoside hydrolase, putativ
— Both
LAEL147_000016200 ⚠
proliferative cell nuclear antigen (PCNA), pu
— Both
LAEL147_000024000 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LAEL147_000799800 ⚠
glyceraldehyde-3-phosphate dehydrogenase-like
— +1 more Both
LAEL147_000023800 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LAEL147_000536200 ⚠
fumarate hydratase, putative
— Both
LAEL147_000168400 ⚠
glucose-6-phosphate isomerase
— Both
LAEL147_000812300 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LAEL147_000606500 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LAEL147_000581100 ⚠
glutamyl-tRNA synthetase, putative
— OG7
LAEL147_000024100 ⚠
long-chain-fatty-acid-CoA ligase, putative
— OG7
LAEL147_000715800 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAEL147_000565500 ⚠
queuine tRNA-ribosyltransferase, putative
— OG7
LAEL147_000865900 ⚠
aldehyde dehydrogenase, putative
— OG7
LAEL147_000464400 ⚠
isovaleryl-coA dehydrogenase, putative
— Both
LAEL147_000577300 ⚠
aldehyde dehydrogenase, putative
— Both
LAEL147_000833700 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
LAEL147_000578000 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LAEL147_000578100 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LAEL147_000511600 ⚠
heat-shock protein hsp70, putative
— OG6
LAEL147_000494700 ⚠
heat-shock protein hsp70, putative
— OG6
LAEL147_000512000 ⚠
heat-shock protein hsp70, putative
— Both
LAEL147_000511500 ⚠
Hsp70 protein, putative
— OG6
LAEL147_000438100 ⚠
heat-shock protein hsp70, putative
— OG6
LAEL147_000454600 ⚠
Queuine tRNA-ribosyltransferase, putative
— Both
LAEL147_000184200 ⚠
adenylosuccinate synthetase, putative
— Both
LAEL147_000147300 ⚠
NGG1 interacting factor 3-like protein
— Both
LAEL147_000062900 ⚠
trypanothione reductase
— Both
LAEL147_000579900 ⚠
valyl-tRNA synthetase, putative
— Both
LAEL147_000524000 ⚠
guanine deaminase, putative
— Both
LAEL147_000169300 ⚠
alanine aminotransferase
— Both
LAEL147_000749600 ⚠
pyruvate kinase
— Both
LAEL147_000749500 ⚠
pyruvate kinase
— Both
LAEL147_000038100 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LAEL147_000016300 ⚠
glutaminyl-tRNA synthetase, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.