LAEL147_000133800

isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania aethiopica L147 OG6: OG6_100639 OG7: OG7_0004251 180 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 180 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAEL147_000313300 ⚠
serine/threonine-protein kinase-like protein
— OG7
LAEL147_000812900 ⚠
protein phosphatase 2C-like protein
— OG6
LAEL147_000493900
electron-transfer-flavoprotein, alpha polypep
— Both
LAEL147_000371900 ⚠
alanine racemase, putative
— Both
LAEL147_000337400
SEP domain containing protein, putative
— Both
LAEL147_000372000 ⚠
Alanine racemase, N-terminal domain containin
— Both
LAEL147_000721400
pyroglutamyl-peptidase I (C15 family)
— Both
LAEL147_000134000 ⚠
protein transport protein SEC23, putative
— Both
LAEL147_000311500
CHORD, putative
— Both
LAEL147_000630800
Alpha/beta hydrolase family, putative
— Both
LAEL147_000727600
protein phosphatase 2C-like protein
— OG6
LAEL147_000742100
phosphomannomutase-like protein
— Both
LAEL147_000299900 ⚠
hypothetical protein, conserved
— Both
LAEL147_000857900 ⚠
mitochondrial intermediate peptidase, putativ
— Both
LAEL147_000312000 ⚠
hypothetical protein, conserved
— Both
LAEL147_000807600 ⚠
stress-inducible protein STI1 homolog
— OG6
LAEL147_000479700 ⚠
TPR-repeat protein, putative
— OG6
LAEL147_000621500
N-myristoyl transferase, putative
— Both
LAEL147_000813400 ⚠
Elongation factor G1, mitochondrial, putative
— Both
LAEL147_000568500
alcohol dehydrogenase, putative
— Both
LAEL147_000229800
dihydroorotase, putative
— Both
LAEL147_000587600
ubiquitin hydrolase, putative
— Both
LAEL147_000675200
nicotinate phosphoribosyltransferase, putativ
— Both
LAEL147_000653300
nucleoside diphosphate kinase b
— Both
LAEL147_000504200
tRNA threonylcarbamoyl adenosine modification
— Both
LAEL147_000696700 ⚠
transcription elongation factor-like protein
— Both
LAEL147_000021100
cyclophilin 12, putative
— OG6
LAEL147_000198800
hypothetical protein
— OG6
LAEL147_000764300 ⚠
choline/ethanolamine kinase, putative
— Both
LAEL147_000462100 ⚠
UBA/TS-N domain containing protein, putative
— Both
LAEL147_000105900
hypothetical protein, conserved
— Both
LAEL147_000148100 ⚠
acidocalcisomal pyrophosphatase
— Both
LAEL147_000045300 ⚠
inorganic pyrophosphatase, putative
— Both
LAEL147_000417800
DnaJ domain containing protein, putative
— Both
LAEL147_000267800
UDP-glucose pyrophosphorylase
— Both
LAEL147_000849200
nudix hydrolase-like protein
— Both
LAEL147_000161900
PITH domain containing protein, putative
— Both
LAEL147_000299300
cytidine triphosphate synthase, putative
— Both
LAEL147_000503400 ⚠
protein kinase, putative
— OG7
LAEL147_000007800 ⚠
serine/threonine protein kinase sos2, putativ
— OG7
LAEL147_000019200 ⚠
MCAK-like kinesin, putative
— OG7
LAEL147_000816800 ⚠
SNF1-related protein kinases, putative
— OG7
LAEL147_000536900 ⚠
serine/threonine protein kinase, putative
— OG7
LAEL147_000684500 ⚠
protein kinase, putative
— OG7
LAEL147_000188700 ⚠
MCAK-like kinesin, putative
— OG7
LAEL147_000035700 ⚠
peptidyl dipeptidase, putative
— OG7
LAEL147_000556100 ⚠
adenosine kinase, putative
— OG7
LAEL147_000441700 ⚠
thimet oligopeptidase, putative
— OG7
LAEL147_000556200 ⚠
pfkB family carbohydrate kinase, putative
— OG7
LAEL147_000556300 ⚠
adenosine kinase-like protein
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.