LAEL147_000148100

acidocalcisomal pyrophosphatase

Leishmania aethiopica L147 OG6: OG6_100346 OG7: OG7_0003350 292 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 292 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000026000 ⚠ ubiquitin activating enzyme, putative	—	OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	OG7
LAEL147_000322800 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LAEL147_000551200 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LAEL147_000198800 ⚠ hypothetical protein	—	OG6 Tb927.11.7060 ↔ Tb927.2.450 OG6 TCSYLVIO_000702 ↔ TCSYLVIO_001709 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003670 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008932 +4 more	OG6
LAEL147_000305600 ⚠ hypothetical protein	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LAEL147_000351600 ⚠ GDP-mannose pyrophosphorylase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LAEL147_000305800 ⚠ hypothetical protein, conserved	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LAEL147_000725600 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.11.7060 ↔ Tb927.4.2310 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003867 OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	Both
LAEL147_000305700 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LAEL147_000103200 ⚠ ubiquitin-activating enzyme-like protein	—	OG6 Tb927.11.7060 ↔ Tb927.5.3430 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010542 OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	Both
LAEL147_000050400 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LAEL147_000749500 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LAEL147_000749600 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LAEL147_000761400 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
LAEL147_000087400 ⚠ alpha-adaptin-like protein	—	OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004455	OG7
LAEL147_000744400 ⚠ adaptor gamma-1 chain, putative	—	OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004455	OG7
LAEL147_000479900 ⚠ aldo-keto reductase-like protein	—	OG7 TCSYLVIO_001508 ↔ TCSYLVIO_004455	OG7
LAEL147_000617500 ⚠ aldehyde reductase, putative	—	OG7 TCSYLVIO_001508 ↔ TCSYLVIO_004455	OG7
LAEL147_000661700 ⚠ Methyltransferase TYW3, putative	—	OG7 Tb927.11.12670 ↔ Tb927.11.7080	OG7
LAEL147_000108900 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000168 ↔ TCSYLVIO_004455	OG7
LAEL147_000694000 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001709	OG7
LAEL147_000174400 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LAEL147_000589200 ⚠ mitotic centromere-associated kinesin (MCAK),	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LAEL147_000188700 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LAEL147_000019200 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LAEL147_000428700 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002376 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002376	Both
LAEL147_000747600 ⚠ nucleolar protein family a, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003690 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003690	Both
LAEL147_000424300 ⚠ Leucine Rich repeats (2 copies), putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006421 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006421	Both
LAEL147_000283400 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006012	Both
LAEL147_000305200 ⚠ Pre-mRNA-splicing factor 38, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007337	Both
LAEL147_000842800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009198	Both
LAEL147_000485900 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002526 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002525 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002526 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002525	Both
LAEL147_000763700 ⚠ threonyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007511	Both
LAEL147_000105200 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010560	Both
LAEL147_000797000 ⚠ CS domain containing protein, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005716	Both
LAEL147_000675200 ⚠ nicotinate phosphoribosyltransferase, putativ	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004898	Both
LAEL147_000259100 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
LAEL147_000010200 ⚠ biotin/lipoate protein ligase-like protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_008176 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_008176	Both
LAEL147_000812900 ⚠ protein phosphatase 2C-like protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007482	OG6
LAEL147_000522700 ⚠ U-box domain protein, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_010665 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_010665	Both
LAEL147_000067600 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_001973 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_001973	Both
LAEL147_000081800 ⚠ acyl-coenzyme a dehydrogenase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_001861 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_001861	Both
LAEL147_000721300 ⚠ Zeta toxin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010958	Both
LAEL147_000164700 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006977	Both
LAEL147_000097700 ⚠ serine/threonine kinase, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_009716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_009716	Both
LAEL147_000639200 ⚠ protein phosphatase 2C, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007482	OG6
LAEL147_000194900 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010327	Both
LAEL147_000596700 ⚠ biotin/lipoate protein ligase-like protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_008176 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_008176	Both
LAEL147_000877300 ⚠ small G-protein, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004644	OG6
LAEL147_000552700 ⚠ nitrate reductase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003124	OG6

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