LAEL147_000351600

GDP-mannose pyrophosphorylase

Leishmania aethiopica L147 OG6: OG6_100460 OG7: OG7_0001668 183 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 183 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000076200 glutamine synthetase, putative	—	OG6 Tb927.7.4970 ↔ Tb927.8.2050 OG6 TCSYLVIO_001811 ↔ TCSYLVIO_007603 OG7 Tb927.7.4970 ↔ Tb927.8.2050 OG7 TCSYLVIO_001811 ↔ TCSYLVIO_007603	Both
LAEL147_000045300 ⚠ inorganic pyrophosphatase, putative	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LAEL147_000148100 ⚠ acidocalcisomal pyrophosphatase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LAEL147_000067600 hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007603	Both
LAEL147_000157100 ⚠ adaptin-related protein-like protein	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007603	OG7
LAEL147_000870300 isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
LAEL147_000401300 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007603	Both
LAEL147_000348700 alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007603	Both
LAEL147_000485900 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	Both
LAEL147_000198800 hypothetical protein	—	OG6 TCSYLVIO_000702 ↔ TCSYLVIO_007603 OG6 TCSYLVIO_006596 ↔ TCSYLVIO_007603 OG6 TCSYLVIO_003670 ↔ TCSYLVIO_007603 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008932 +2 more	OG6
LAEL147_000358000 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
LAEL147_000878700 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
LAEL147_000205600 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010621	Both
LAEL147_000522500 ⚠ heat shock protein 90, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008621 +2 more	Both
LAEL147_000245000 ⚠ Dihydrouridine synthase (Dus), putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009102	Both
LAEL147_000333100 ATP synthase F1 subunit gamma protein, putati	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009375	Both
LAEL147_000206000 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010624	Both
LAEL147_000310500 tRNA (Uracil-5-)-methyltransferase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008409 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008409	Both
LAEL147_000808500 PUB domain containing protein, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009932	Both
LAEL147_000320500 methionyl-tRNA synthetase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_007991	Both
LAEL147_000133600 Exonuclease, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010944	Both
LAEL147_000354000 pteridine reductase 1	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008848 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008848	Both
LAEL147_000668200 ⚠ heat shock protein 83-17	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008621 +2 more	Both
LAEL147_000514600 transcription factor-like protein	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010728	Both
LAEL147_000507400 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010621	Both
LAEL147_000515000 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010724	Both
LAEL147_000060700 dihydrolipoamide branched chain transacylase,	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009880	Both
LAEL147_000194900 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010327	Both
LAEL147_000425700 hypothetical protein, conserved	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010323 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010323	Both
LAEL147_000103200 ⚠ ubiquitin-activating enzyme-like protein	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010542	Both
LAEL147_000109100 ⚠ mitochondrial DNA polymerase beta	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010588 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010588	Both
LAEL147_000721300 Zeta toxin, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010958	Both
LAEL147_000105200 WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010560	Both
LAEL147_000842800 hypothetical protein, conserved	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009198	Both
LAEL147_000664000 Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007603	Both
LAEL147_000144300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
LAEL147_000445100 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
LAEL147_000552200 hypothetical protein, conserved	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007603	Both
LAEL147_000396000 tubulin folding cofactor D, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007603	Both
LAEL147_000424300 Leucine Rich repeats (2 copies), putative	—	OG6 TCSYLVIO_006421 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006421 ↔ TCSYLVIO_007603	Both
LAEL147_000756200 vacuolar ATP synthase subunit d, putative	—	OG6 TCSYLVIO_005104 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_007603	Both
LAEL147_000855700 paraflagellar rod component, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007603	OG6
LAEL147_000283400 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007603	Both
LAEL147_000484800 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
LAEL147_000049200 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
LAEL147_000694000 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007603	OG7
LAEL147_000737800 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007603	OG7
LAEL147_000692300 ⚠ heat shock protein, putative	—	OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009151	OG7
LAEL147_000354300 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010724	OG7
LAEL147_000606500 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009102	OG7

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