LPAL13_320047900

SPRY domain/HECT-domain (ubiquitin-transferase), putative
Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_147203 OG7: OG7_0031172 88 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 88 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LPAL13_270021800
proteasome regulatory non-ATP-ase subunit 3,
— Both
LPAL13_200020000 ⚠
N-terminal region of Chorein, a TM vesicle-me
— OG7
LPAL13_160020600 ⚠
WD domain, G-beta repeat, putative
— OG7
LPAL13_300023800
cyclosome subunit-like protein
— Both
LPAL13_090017700
AAA family ATPase, putative
— Both
LPAL13_320028200
RNA recognition motif. (a.k.a. RRM, RBD, or R
— Both
LPAL13_350052900
proteasome regulatory ATPase subunit
— OG6
LPAL13_170015000 ⚠
ATP-dependent RNA helicase, putative
— Both
LPAL13_210012700
proteasome regulatory non-ATP-ase subunit 5,
— Both
LPAL13_070017500
proteasome regulatory non-ATP-ase subunit, pu
— Both
LPAL13_130008000 ⚠
ATP-dependent RNA helicase, putative
— Both
LPAL13_090014400 ⚠
hypothetical protein, conserved
— OG7
LPAL13_290006200
proteasome regulatory non-ATPase subunit, put
— Both
LPAL13_340045600
U5 snRNA-associated splicing factor
— Both
LPAL13_190017600
proteasome regulatory non-ATP-ase subunit 9,
— Both
LPAL13_000013100
WD domain, G-beta repeat, putative
— Both
LPAL13_120007000
proteasome regulatory ATPase subunittcc1l8.3,
— OG6
LPAL13_170013800
OSM3-like kinesin, putative
— OG6
LPAL13_320009000
19S proteasome non-atpase subunit 8
— Both
LPAL13_320036000
proteasome regulatory non-ATP-ase subunit, pu
— Both
LPAL13_150016300 ⚠
Cyclic nucleotide-binding domain containing p
— Both
LPAL13_240015100
hypothetical protein, conserved
— Both
LPAL13_300037200 ⚠
Ankyrin repeats (3 copies), putative
— OG7
LPAL13_200031200 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LPAL13_130006800 ⚠
protein kinase A regulatory subunit, putative
— OG7
LPAL13_320048300 ⚠
cAMP response protein, putative
— OG7
LPAL13_200048200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LPAL13_230023400 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LPAL13_320020400 ⚠
DEAD/DEAH box helicase-like protein, putative
— OG7
LPAL13_030007500 ⚠
hypothetical protein, conserved
— OG7
LPAL13_030007400 ⚠
FYVE zinc finger containing protein, putative
— OG7
LPAL13_200061200 ⚠
Raptor N-terminal CASPase like domain contain
— OG7
LPAL13_200037300 ⚠
cleavage and polyadenylation specificity fact
— OG7
LPAL13_120010700 ⚠
TPR repeat/Tetratricopeptide repeat, putative
— Both
LPAL13_040011100 ⚠
palmitoyl acyltransferase 1, putative
— OG7
LPAL13_290015500 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— OG7
LPAL13_330006500 ⚠
Ankyrin repeats (3 copies), putative
— OG7
LPAL13_340031100 ⚠
ankyrin repeat protein, putative
— OG7
LPAL13_260012100 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LPAL13_350033700 ⚠
cyclin-e binding protein 1-like protein
— OG7
LPAL13_350049800 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LPAL13_200022200 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LPAL13_110006600 ⚠
chromatin binding protein, putative
— OG7
LPAL13_310033600 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LPAL13_240026800
hypothetical protein, conserved
— Both
LPAL13_300010400
hypothetical protein, conserved
— Both
LPAL13_200010900
proteasome regulatory non-ATPase subunit 11,
— Both
LPAL13_320018000
proteasome regulatory non-ATP-ase subunit, pu
— Both
LPAL13_280024900
proteasome regulatory non-ATP-ase subunit 2,
— Both
LPAL13_220010900
proteasome regulatory ATPase subunit 5, putat
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.