LTRL590_170006900

cystathionine beta-synthase
Leishmania tropica L590 OG6: OG6_100154 OG7: OG7_0002172 87 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 87 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LTRL590_230015600 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LTRL590_070015100 ⚠
N-acetylglucosamine-phosphate mutase, putativ
— +2 more Both
LTRL590_260013000 ⚠
aspartate--ammonia ligase, putative
— Both
LTRL590_230011300 ⚠
AMP-binding enzyme/AMP-binding enzyme C-termi
— +1 more Both
LTRL590_230011400 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LTRL590_270025900 ⚠
trypanothione synthetase, putative
— Both
LTRL590_290036100 ⚠
inosine-adenosine-guanosine-nucleoside hydrol
— Both
LTRL590_330034800 ⚠
mitochondrial processing peptidase alpha subu
— Both
LTRL590_210008900 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LTRL590_130012900 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LTRL590_090013900 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
LTRL590_270027700 ⚠
branched-chain amino acid aminotransferase, p
— Both
LTRL590_230015400 ⚠
3-ketoacyl-CoA thiolase, putative
— Both
LTRL590_200011700 ⚠
cytidine triphosphate synthase, putative
— Both
LTRL590_270027900 ⚠
hypothetical protein
— Both
LTRL590_290030000 ⚠
aminopeptidase, putative
— Both
LTRL590_300018800 ⚠
pyridoxal kinase, putative
— Both
LTRL590_360080100 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LTRL590_240028600 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— Both
LTRL590_140009200 ⚠
threonine synthase, putative
— Both
LTRL590_040010700 ⚠
spermidine synthase
— Both
LTRL590_280036100 ⚠
cytosolic malate dehydrogenase
— Both
LTRL590_220016900 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LTRL590_270028000 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LTRL590_270014200
WD domain, G-beta repeat, putative
— OG7
LTRL590_260007600 ⚠
aminopeptidase-like protein
— OG7
LTRL590_280030400 ⚠
mitochondrial DNA topoisomerase II
— Both
LTRL590_360055500 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LTRL590_150007700 ⚠
sterol carrier protein, putative
— OG7
LTRL590_230010400 ⚠
trypanothione synthetase, putative
— OG7
LTRL590_350008300 ⚠
serine palmitoyltransferase, putative
— OG7
LTRL590_120014700 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
LTRL590_330037200 ⚠
D-alanyl-glycyl endopeptidase-like protein
— OG7
LTRL590_250031600 ⚠
glutathionylspermidine synthase, putative
— OG7
LTRL590_330037600 ⚠
D-alanyl-glycyl endopeptidase-like protein
— OG7
LTRL590_340042900 ⚠
serine palmitoyltransferase-like protein
— OG7
LTRL590_340033300 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LTRL590_320047900 ⚠
cAMP response protein, putative
— OG7
LTRL590_260025400 ⚠
Methyltransferase domain containing protein,
— OG7
LTRL590_340022200 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LTRL590_250022100 ⚠
PUA domain/NOL1/NOP2/sun family, putative
— OG7
LTRL590_310006700 ⚠
nucleolar protein, putative
— OG7
LTRL590_150017400 ⚠
protein kinase, putative
— OG7
LTRL590_310006800 ⚠
hypothetical protein
— OG7
LTRL590_280024300 ⚠
NOL1/NOP2/sun family, putative
— OG7
LTRL590_290027100 ⚠
NOL1/NOP2/sun family, putative
— OG7
LTRL590_330042100 ⚠
hypothetical protein, conserved
— Both
LTRL590_000026300 ⚠
mitogen activated protein kinase 4, putative
— OG6
LTRL590_300011800 ⚠
nitrate reductase, putative
— OG6
LTRL590_130006500 ⚠
protein kinase A regulatory subunit, putative
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.