LTRL590_280009400

DIS3-like exonuclease, putative

Leishmania tropica L590 OG6: OG6_102526 OG7: OG7_0002439 242 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 242 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_110013400 ⚠ Cytosol aminopeptidase family, catalytic doma	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LTRL590_000028900 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_000006000 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LTRL590_350052400 ⚠ Cysteine-rich motif following a subset of SET	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005710 +1 more	Both
LTRL590_200022100 ⚠ Peptidase family M20/M25/M40, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_000029000 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_310018200 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_150012400 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 LdBPK_150720.1 ↔ LdBPK_280470.1	Both
LTRL590_250014900 ⚠ protein kinase, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007401 +1 more	Both
LTRL590_200022000 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_300020100 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_140021300 ⚠ inositol-3-phosphate synthase	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 +1 more	Both
LTRL590_230023700 ⚠ aminoacyclase, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	OG7
LTRL590_330034200 ⚠ aminopeptidase, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
LTRL590_330021400 ⚠ protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007401 OG7 LdBPK_280470.1 ↔ LdBPK_331490.1	OG7
LTRL590_120013400 ⚠ hypothetical protein	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_000028800 ⚠ Peptidase dimerisation domain/Peptidase famil	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LTRL590_310018100 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	OG7
LTRL590_210005500 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006877 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006877	OG7
LTRL590_300039700 ⚠ tRNA (Guanine-1)-methyltransferase, putative	—	OG7 LdBPK_280470.1 ↔ LdBPK_303110.1	OG7
LTRL590_340018200 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_280470.1 ↔ LdBPK_341230.1	OG7
LTRL590_180011900 ⚠ serine/threonine kinase-like protein, putativ	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
LTRL590_300013000 ⚠ heat shock protein grpe	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003139	OG7
LTRL590_220018600 ⚠ fk506-binding protein 1-like protein	—	OG7 LdBPK_280470.1 ↔ LdBPK_291330.1	OG7
LTRL590_260019000 ⚠ MORN repeat/FYVE zinc finger containing prote	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006188	OG7
LTRL590_000019000 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
LTRL590_160018500 ⚠ WW domain containing protein, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003155	OG7
LTRL590_340018100 ⚠ Dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
LTRL590_040008100 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_002526	OG7
LTRL590_330024900 ⚠ protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
LTRL590_040010100 ⚠ palmitoyl acyltransferase 1, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004284	OG7
LTRL590_350060300 ⚠ ribosome-interacting GTPase 2, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005006	OG7
LTRL590_300034700 ⚠ GTPase activator-like protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_008881	OG7
LTRL590_350036700 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005838	OG7
LTRL590_180007500 ⚠ RNA-binding protein 29, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_006152	OG7
LTRL590_350028800 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
LTRL590_360076300 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
LTRL590_360014900 ⚠ SNF1-related protein kinases, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
LTRL590_360030300 ⚠ developmentally regulated GTP-binding protein	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005006	OG7
LTRL590_290026700 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	OG7
LTRL590_300037600 ⚠ Ankyrin repeats (3 copies), putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004284	OG7
LTRL590_230008600 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010724	OG7
LTRL590_340040900 ⚠ Programmed cell death protein 2, C-terminal p	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_008261	OG7
LTRL590_180016600 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004998	OG7
LTRL590_300012500 ⚠ nuclear movement protein, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010327	OG7
LTRL590_350041200 ⚠ zinc finger protein, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006188	OG7
LTRL590_180015900 ⚠ 5-oxoprolinase, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_006232	OG7
LTRL590_330009000 ⚠ ATP-binding cassette sub-family F member 1, p	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006012	OG7
LTRL590_210007000 ⚠ serine/threonine-protein kinase-like protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
LTRL590_030009800 ⚠ Ankyrin repeats (3 copies)/DHHC palmitoyltran	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004284	OG7

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