LTRL590_350039700

Putative death-receptor fusion protein (DUF2428), putative
Leishmania tropica L590 OG6: OG6_146318 OG7: OG7_0006293 115 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 115 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LTRL590_350014600 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
LTRL590_220019500 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG6
LTRL590_220019400 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG6
LTRL590_040008300
hypothetical protein, conserved
— Both
LTRL590_180019700
Protein of unknown function (DUF3648), putati
— Both
LTRL590_360074000
hypothetical protein, conserved
— Both
LTRL590_360032900
hypothetical protein, conserved
— Both
LTRL590_360015900
hypothetical protein, conserved
— Both
LTRL590_360069500
Rab3 GTPase-activating protein regulatory sub
— Both
LTRL590_360068300 ⚠
hypothetical protein, conserved
— Both
LTRL590_360033100
hypothetical protein, conserved
— Both
LTRL590_340049200
coatomer alpha subunit, putative
— Both
LTRL590_160012800 ⚠
ubiquitin hydrolase, putative
— Both
LTRL590_290034700
serine/threonine-protein kinase Nek3, putativ
— OG6
LTRL590_060006700
hypothetical protein, conserved
— Both
LTRL590_300035500 ⚠
protein mkt1, putative
— Both
LTRL590_340032900
hypothetical protein, conserved
— Both
LTRL590_150015600
protein phosphatase 2A regulatory subunit, pu
— Both
LTRL590_320041200 ⚠
chaperonin alpha subunit, putative
— +4 more Both
LTRL590_010009300 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
LTRL590_060013500
hypothetical protein, conserved
— Both
LTRL590_250019800 ⚠
RNA-binding protein RBP10, putative
— Both
LTRL590_130015500 ⚠
DNA-directed RNA polymerase I subunit, putati
— Both
LTRL590_170006700 ⚠
WD domain, G-beta repeat, putative
— OG7
LTRL590_240011900 ⚠
ubiquitin hydrolase, putative
— OG7
LTRL590_300018300 ⚠
ubiquitin hydrolase, putative
— OG7
LTRL590_210009500 ⚠
Peptidase C19, ubiquitin carboxyl-terminal hy
— OG7
LTRL590_320022300 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LTRL590_360056800 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LTRL590_270007000 ⚠
proteasome alpha 7 subunit, putative
— OG7
LTRL590_210014300 ⚠
Temperature dependent protein affecting M2 ds
— OG7
LTRL590_310021300 ⚠
'Cold-shock' DNA-binding domain containing pr
— OG7
LTRL590_000016100 ⚠
'Cold-shock' DNA-binding domain containing pr
— OG7
LTRL590_320013300 ⚠
cyclin 9, putative
— OG7
LTRL590_340037800 ⚠
Zn-finger in ubiquitin-hydrolases and other p
— OG7
LTRL590_360005900 ⚠
leucine carboxyl methyltransferase, putative
— OG7
LTRL590_090018400 ⚠
hypothetical protein, conserved
— OG7
LTRL590_350022600 ⚠
ubiquitin hydrolase, putative
— OG7
LTRL590_340046700 ⚠
ubiquitin hydrolase, putative
— OG7
LTRL590_210026200 ⚠
proteasome alpha 2 subunit, putative
— OG7
LTRL590_110007600 ⚠
proteasome alpha 7 subunit, putative
— OG7
LTRL590_140008800 ⚠
proteasome alpha 3 subunit, putative
— OG7
LTRL590_350055300 ⚠
proteasome alpha 1 subunit, putative
— OG7
LTRL590_130021800 ⚠
chaperonin TCP20, putative
— +3 more OG7
LTRL590_000021600 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LTRL590_270010700 ⚠
replication factor C, subunit 4, putative
— OG7
LTRL590_360084500 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LTRL590_290018200 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LTRL590_300032500 ⚠
replication factor C, subunit 2, putative
— OG7
LTRL590_110006500 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.