LbrM.22.1540

ccr4-not transcription complex subunit
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_101138 OG7: OG7_0005422 150 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 150 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.21.0890
CCR4-NOT transcription complex subunit 1
— Both
LbrM.20.4010
cell differentiation protein-like protein
— Both
LbrM.25.1400
General negative regulator of transcription s
— Both
LbrM.23.0020
hypothetical protein, conserved
— Both
LbrM.02.0130 ⚠
phosphatidylinositol kinase related protein,
— OG7
LbrM.05.1110 ⚠
DNA-directed RNA polymerase I largest subunit
— Both
LbrM.16.1400 ⚠
DNA-directed rna polymerase I largest subunit
— Both
LbrM.19.1160 ⚠
kinesin, putative (fragment)
— OG6
LbrM.19.1150 ⚠
Flagellum attachment zone protein 7 (fragment
— OG6
LbrM.15.0760
hypothetical protein, unknown function
— Both
LbrM.22.1500
hypothetical protein, conserved
— Both
LbrM.14.0550
WD domain, G-beta repeat, putative
— Both
LbrM.12.0610 ⚠
TPR repeat, putative
— Both
LbrM.06.1140
hypothetical protein, conserved
— Both
LbrM.16.0390 ⚠
tubulin tyrosine ligase, putative
— Both
LbrM.09.1270
AAA family ATPase, putative
— Both
LbrM.30.2140
RNA-binding protein, putative
— OG6
LbrM.05.1080 ⚠
Phosphatidylinositol 4-phosphate 5-kinase, pu
— OG7
LbrM.20.1950 ⚠
Sec7 domain containing protein, putative
— OG7
LbrM.20.2060 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LbrM.34.5330 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LbrM.30.1210 ⚠
WW domain containing protein, putative
— OG7
LbrM.16.1170 ⚠
WW domain containing protein, putative
— OG7
LbrM.30.1030 ⚠
ubiquitin-protein ligase, putative
— OG7
LbrM.05.0420 ⚠
TPR repeat, putative
— OG7
LbrM.18.0390 ⚠
tubulin tyrosine ligase protein, putative
— OG7
LbrM.32.3180 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LbrM.30.2230 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LbrM.11.0080 ⚠
tubulin-tyrsoine ligase-like protein
— OG7
LbrM.34.4880 ⚠
tubulin tyrosine ligase, putative
— OG7
LbrM.29.0520 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LbrM.11.0620 ⚠
tubulin-tyrsoine ligase-like protein (fragmen
— OG7
LbrM.20.4970 ⚠
tubulin-tyrosine ligase, putative
— OG7
LbrM.27.2700 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LbrM.30.3410
hypothetical protein, conserved
— OG7
LbrM.35.3160 ⚠
phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LbrM.28.2580 ⚠
DNA replication licensing factor MCM6, putati
— OG7
LbrM.20.4090 ⚠
DNA-directed RNA polymerase III, putative
— OG7
LbrM.35.6620 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
LbrM.06.0510 ⚠
SpoU rRNA Methylase family, putative
— OG7
LbrM.28.2310 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.13.1230 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LbrM.32.1620 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
LbrM.31.2990 ⚠
acetoin dehydrogenase e3 component-like prote
— OG7
LbrM.32.3220 ⚠
DNA replication licensing factor MCM7, putati
— OG7
LbrM.31.0230 ⚠
dihydrolipoamide dehydrogenase
— OG7
LbrM.24.0920 ⚠
DNA replication licensing factor MCM5, putati
— OG7
LbrM.35.7120 ⚠
beta adaptin, putative
— OG7
LbrM.09.0640 ⚠
ubiquitin-fusion protein
— OG7
LbrM.24.1720 ⚠
SpoU rRNA Methylase family, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.