LbrM.27.1750

Eukaryotic translation initiation factor 4E-1
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100627 OG7: OG7_0002303 218 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 218 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.23.1810 ⚠
neutral sphingomyelinase activation associate
— OG7
LbrM.25.0910 ⚠
dehydrogenase-like protein
— OG7
LbrM.13.0440 ⚠
hypothetical protein, conserved
— OG7
LbrM.28.1490 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LbrM.28.1530 ⚠
hypothetical protein, conserved
— OG7
LbrM.02.0180 ⚠
hypothetical protein, conserved
— OG7
LbrM.28.2590 ⚠
WW domain containing protein, putative
— OG7
LbrM.12.0530 ⚠
WW domain containing protein, putative
— OG7
LbrM.17.1250 ⚠
WW domain containing protein, putative
— OG7
LbrM.19.1800 ⚠
choline/Carnitine o-acyltransferase-like prot
— OG7
LbrM.22.0300 ⚠
carnitine palmitoyltransferase-like protein
— OG7
LbrM.26.2250 ⚠
hypothetical protein, conserved
— OG7
LbrM.15.0430 ⚠
hypothetical protein, conserved
— OG7
LbrM.07.0050 ⚠
alpha-adaptin-like protein
— OG7
LbrM.35.1910 ⚠
hypothetical protein, conserved
— OG7
LbrM.33.2730 ⚠
Flagellum attachment zone protein 12
— OG7
LbrM.23.0130 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LbrM.35.0870 ⚠
hypothetical protein, conserved
— OG7
LbrM.33.3020 ⚠
translation initiation factor IF-2, putative
— OG7
LbrM.30.0540 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.20.0340 ⚠
Conserved oligomeric complex COG6, putative
— OG7
LbrM.33.2150 ⚠
hypothetical protein, conserved
— OG7
LbrM.30.0640 ⚠
hypothetical protein, conserved
— OG7
LbrM.32.1080 ⚠
Vps23 core domain containing protein, putativ
— OG7
LbrM.20.3600 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
LbrM.32.1940 ⚠
phosphatidylethanolamine-binding protein, put
— OG7
LbrM.33.3060 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LbrM.21.1130 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.30.1210 ⚠
WW domain containing protein, putative
— OG7
LbrM.17.0530 ⚠
ATPase family associated with various cellula
— OG7
LbrM.30.2590 ⚠
replication factor C, subunit 2, putative
— OG7
LbrM.24.1000 ⚠
replication factor C, subunit 1, putative
— OG7
LbrM.20.5250 ⚠
hypothetical protein, conserved
— OG7
LbrM.27.0660 ⚠
replication factor C, subunit 4, putative
— OG7
LbrM.35.7070 ⚠
replication factor C subunit 3, putative
— OG7
LbrM.31.3240 ⚠
aldehyde reductase, putative, oxidoreductase,
— OG7
LbrM.27.2620 ⚠
aldo-keto reductase-like protein
— OG7
LbrM.28.2661 ⚠
40S ribosomal protein S29, putative
— OG7
LbrM.28.2401 ⚠
40S ribosomal protein S29, putative
— OG7
LbrM.24.2100 ⚠
tubulin folding cofactor D, putative
— OG7
LbrM.34.5330 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LbrM.07.0290 ⚠
ubiquitin-protein ligase-like, putative
— OG7
LbrM.35.0220 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
LbrM.14.1210 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LbrM.34.4770 ⚠
BRCA1 C Terminus (BRCT) domain containing pro
— OG7
LbrM.35.1920 ⚠
hypothetical protein, conserved
— OG7
LbrM.20.1840 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
LbrM.35.5550 ⚠
hypothetical protein, conserved
— OG7
LbrM.07.0840 ⚠
6-phosphofructo-2-kinase-like protein
— OG7
LbrM.24.0020 ⚠
clathrin coat assembly protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.