LbrM.23.1810

neutral sphingomyelinase activation associated factor-like protein
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_104527 OG7: OG7_0001358 231 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 231 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.34.2430 ⚠
hypothetical protein, conserved
— OG7
LbrM.30.2790 ⚠
chaperonin HSP60/CNP60, putative
— OG7
LbrM.32.0780 ⚠
ubiquitin-conjugating enzyme E2, putative
— OG7
LbrM.35.2240 ⚠
chaperonin HSP60, mitochondrial precursor
— OG7
LbrM.27.0700 ⚠
Domain of unknown function (DUF4470)/Domain o
— OG7
LbrM.34.5280 ⚠
Dynein heavy chain and region D6 of dynein mo
— OG7
LbrM.04.1100 ⚠
hypothetical protein, conserved
— OG7
LbrM.11.0810 ⚠
inositol-1,4,5-trisphosphate (IP3) 5-phosphat
— OG7
LbrM.33.2070 ⚠
hypothetical protein, conserved
— OG7
LbrM.13.1340 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.3440 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.2380 ⚠
hypothetical protein, conserved
— OG7
LbrM.30.1800 ⚠
microtubule associated protein xmap215
— OG7
LbrM.33.1750 ⚠
hypothetical protein, conserved
— OG7
LbrM.21.1420 ⚠
hypothetical protein, conserved
— OG7
LbrM.23.1500 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LbrM.02.0170 ⚠
RNA helicase, putative (fragment)
— OG7
LbrM.17.0940 ⚠
ATP-dependent RNA helicase, putative
— OG7
LbrM.13.0320 ⚠
ATP-dependent RNA helicase, putative
— OG7
LbrM.32.1560 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LbrM.11.0780 ⚠
HIT zinc finger, putative
— OG7
LbrM.20.0340 ⚠
Conserved oligomeric complex COG6, putative
— OG7
LbrM.22.0770 ⚠
hypothetical protein, conserved
— OG7
LbrM.20.0330 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
LbrM.16.1400 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
LbrM.31.2950 ⚠
RNA polymerase ii largest subunit
— OG7
LbrM.34.1110 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LbrM.34.4240 ⚠
hypothetical protein, conserved
— OG7
LbrM.34.0820 ⚠
NADH-dependent fumarate reductase-like protei
— OG7
LbrM.05.0860 ⚠
CPSF A subunit region, putative
— OG7
LbrM.23.0610 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.7120 ⚠
beta adaptin, putative
— OG7
LbrM.33.2870 ⚠
hypothetical protein, conserved
— OG7
LbrM.34.1090 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LbrM.31.2980 ⚠
2-oxoglutarate dehydrogenase, e3 component, l
— OG7
LbrM.31.0230 ⚠
dihydrolipoamide dehydrogenase
— OG7
LbrM.24.1720 ⚠
SpoU rRNA Methylase family, putative
— OG7
LbrM.32.3220 ⚠
DNA replication licensing factor MCM7, putati
— OG7
LbrM.28.2310 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.20.1390 ⚠
Nucleoporin NUP225
— OG7
LbrM.34.1100 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LbrM.34.2590 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.4460 ⚠
WD domain, G-beta repeat/Utp21 specific WD40
— OG7
LbrM.14.1340 ⚠
ras-like small GTPases, putative
— OG7
LbrM.25.0490 ⚠
hypothetical protein, conserved
— OG7
LbrM.32.0200 ⚠
Flagellum attachment zone protein 9
— OG7
LbrM.32.0810 ⚠
hypothetical protein, conserved
— OG7
LbrM.26.1280 ⚠
hypothetical protein, unknown function
— OG7
LbrM.20.1740 ⚠
Glycosyl hydrolase family 65 central catalyti
— OG7
LbrM.35.5900 ⚠
isoleucyl-tRNA synthetase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.