LbrM.35.5900

isoleucyl-tRNA synthetase, putative

Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100811 OG7: OG7_0003029 205 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 205 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LbrM.11.0400 ⚠ aminopeptidase, putative, metallo-peptidase,	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LbrM.11.0410 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LbrM.20.1840 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.4.2310 OG6 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 +1 more	Both
LbrM.22.0420 ⚠ Putative tRNA binding domain containing prote	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
LbrM.16.1160 ⚠ tyrosyl or methionyl-tRNA synthetase-like pro	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
LbrM.13.0900 leucyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004705	Both
LbrM.14.1560 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 Tb927.10.9190 ↔ Tb927.8.5330	Both
LbrM.33.2840 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LbrM.31.1330 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LbrM.20.5910 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LbrM.20.5920 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LbrM.30.1491 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LbrM.20.5930 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LbrM.30.0540 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
LbrM.21.1130 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
LbrM.14.0460 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010327	Both
LbrM.33.0500 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_365870.1	OG7
LbrM.20.1020 ⚠ TPR repeat/SET domain containing protein, put	—	OG7 LdBPK_080820.1 ↔ LdBPK_365870.1	OG7
LbrM.23.0910 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_365870.1	OG7
LbrM.20.6030 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_365870.1	OG7
LbrM.32.2360 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_070810.1 ↔ LdBPK_365870.1	OG7
LbrM.04.0360 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
LbrM.28.0340 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
LbrM.12.0300 ornithine decarboxylase, putative	—	OG6 LdBPK_120105.1 ↔ LdBPK_365870.1 OG7 LdBPK_120105.1 ↔ LdBPK_365870.1	Both
LbrM.25.0360 translation initiation factor SUI1, putative	—	OG6 LdBPK_250420.1 ↔ LdBPK_365870.1 OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	Both
LbrM.19.0110 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
LbrM.03.0820 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
LbrM.30.0820 ⚠ co-chaperone GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_004705	Both
LbrM.32.4220 Gar1/Naf1 RNA binding region, putative	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_004705	Both
LbrM.29.0610 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_290620.1 ↔ LdBPK_365870.1 OG7 LdBPK_290620.1 ↔ LdBPK_365870.1	Both
LbrM.35.0200 PUB domain containing protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009932	Both
LbrM.35.4280 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008197	Both
LbrM.34.0890 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005125	Both
LbrM.27.0470 Nuclear pore complex protein 158	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007387	Both
LbrM.29.2510 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004998	Both
LbrM.18.0110 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
LbrM.29.0070 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010724	Both
LbrM.33.1320 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004910 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004910	Both
LbrM.25.0750 ⚠ protein kinase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007401	Both
LbrM.20.5310 Pre-mRNA-splicing factor 38, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007337	Both
LbrM.27.0360 protein kinase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005149	OG6
LbrM.28.2560 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010621	Both
LbrM.18.0940 hypothetical protein, conserved, cyclosporin	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006217	OG6
LbrM.34.2630 acyl-CoA dehydrogenase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005872 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005872	Both
LbrM.14.1540 myo-inositol-1-phosphate synthase, inositol-3	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007453	Both
LbrM.23.0120 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
LbrM.14.1490 ⚠ serine hydroxymethyltranferase (SHMT-S)	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010621	Both
LbrM.25.1690 eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006404	Both
LbrM.35.2410 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004998	Both
LbrM.34.1340 peroxisome targeting signal 1 receptor, putat	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005361 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005361	Both

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