LbrM.03.0820

inorganic pyrophosphatase, putative

Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100346 OG7: OG7_0003350 292 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 292 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LbrM.30.0540 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LbrM.01.0690 ⚠ ubiquitin activating enzyme, putative	—	OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	OG7
LbrM.21.1130 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LbrM.20.1840 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.11.7060 ↔ Tb927.4.2310 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003867 OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	Both
LbrM.20.5380 ⚠ calpain-like cysteine peptidase, putative, cy	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LbrM.04.0490 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LbrM.08.0230 ⚠ ubiquitin-activating enzyme-like protein (fra	—	OG6 Tb927.11.7060 ↔ Tb927.5.3430 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010542 OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	Both
LbrM.23.0120 ⚠ GDP-mannose pyrophosphorylase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LbrM.20.5390 ⚠ calpain-like cysteine peptidase, putative, cy	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LbrM.20.5340 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LbrM.34.0040 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LbrM.34.0060 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LbrM.34.0070 ⚠ pyruvate kinase, putative (fragment)	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LbrM.34.0010 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LbrM.26.1010 ⚠ glucosidase II beta subunit-like protein, put	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002315 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002315	Both
LbrM.10.1490 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000168 ↔ TCSYLVIO_004455	OG7
LbrM.33.2840 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001709	OG7
LbrM.13.1470 ⚠ Kinesin-13 5, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LbrM.01.0060 ⚠ Kinesin-13 1, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LbrM.31.0400 ⚠ Kinesin-13 4, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LbrM.13.0120 ⚠ Kinesin-13 2, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LbrM.24.2100 ⚠ tubulin folding cofactor D, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001709 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001709	Both
LbrM.34.1330 ⚠ threonyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007511	Both
LbrM.35.0200 ⚠ PUB domain containing protein, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009932	Both
LbrM.35.6380 ⚠ disgorgin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004663 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004663	Both
LbrM.33.2190 ⚠ ribosome assembly protein RRB1, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005619 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005619	Both
LbrM.01.0030 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003428 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003428	Both
LbrM.22.1120 ⚠ translation initiation factor IF-2, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_001768	Both
LbrM.26.1830 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003586	Both
LbrM.29.2510 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004998	Both
LbrM.27.0470 ⚠ Nuclear pore complex protein 158	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007387	Both
LbrM.34.4450 ⚠ Co-chaperone protein P23	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005716	Both
LbrM.20.4840 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007293 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007293	Both
LbrM.35.0680 ⚠ Elongation factor G1, mitochondrial, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007487 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007487	Both
LbrM.10.0310 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_010946 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_010946	Both
LbrM.34.1100 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
LbrM.30.0640 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003118 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003118	Both
LbrM.15.0040 ⚠ Possible lysine decarboxylase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002403 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002403	Both
LbrM.29.2090 ⚠ UDP-glucose:glycoprotein glucosyltransferase,	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004363	Both
LbrM.25.1250 ⚠ NPL4 family, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005923 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005923	Both
LbrM.25.1070 ⚠ TAP42-like family, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006262 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006262	Both
LbrM.18.0110 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
LbrM.34.1090 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
LbrM.35.7120 ⚠ beta adaptin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004597	Both
LbrM.35.2630 ⚠ serine peptidase, Clan SC, Family S9B	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007536	Both
LbrM.20.3350 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003737 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003737	Both
LbrM.30.0390 ⚠ kinesin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003093	OG6
LbrM.13.0900 ⚠ leucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003028 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003028	Both
LbrM.10.0200 ⚠ Mitogen-activated protein kinase 10, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_010938	OG6
LbrM.14.0460 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010327	Both

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