LbrM.08.0230

ubiquitin-activating enzyme-like protein (fragment)
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_101769 OG7: OG7_0003569 136 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 136 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.19.0110 ⚠
acidocalcisomal pyrophosphatase
— Both
LbrM.03.0820 ⚠
inorganic pyrophosphatase, putative
— Both
LbrM.20.5340 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LbrM.20.5390 ⚠
calpain-like cysteine peptidase, putative, cy
— OG6
LbrM.04.0490 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LbrM.20.5380 ⚠
calpain-like cysteine peptidase, putative, cy
— OG6
LbrM.08.0470 ⚠
WD domain, G-beta repeat, putative
— Both
LbrM.30.0640 ⚠
hypothetical protein, conserved
— Both
LbrM.33.2190 ⚠
ribosome assembly protein RRB1, putative
— Both
LbrM.01.0190 ⚠
LSM domain containing protein, putative
— OG7
LbrM.29.0780 ⚠
heat shock protein 90, putative
— +2 more Both
LbrM.33.0340 ⚠
heat shock protein 83, heat shock protein 83-
— +2 more Both
LbrM.33.0330 ⚠
heat shock protein 83-1
— +2 more Both
LbrM.15.0310 ⚠
ribonucleoprotein p18, mitochondrial precurso
— Both
LbrM.15.0320 ⚠
ribonucleoprotein p18, mitochondrial precurso
— Both
LbrM.01.0030 ⚠
DNA-damage inducible protein DDI1-like protei
— Both
LbrM.24.1970 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— Both
LbrM.32.0280 ⚠
Histone chaperone Rttp106-like, putative
— Both
LbrM.20.4500 ⚠
developmentally regulated phosphoprotein-like
— Both
LbrM.23.0650 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
LbrM.35.6680 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
LbrM.25.0490 ⚠
hypothetical protein, conserved
— Both
LbrM.35.3310 ⚠
hypothetical protein, conserved
— Both
LbrM.10.1320 ⚠
hypothetical protein, conserved
— Both
LbrM.26.1830 ⚠
hypothetical protein, conserved
— Both
LbrM.09.0820 ⚠
ubiquitin ligase, putative
— Both
LbrM.23.0120 ⚠
GDP-mannose pyrophosphorylase
— Both
LbrM.25.1890 ⚠
Leucine Rich repeats (2 copies), putative
— Both
LbrM.34.0690 ⚠
vacuolar ATP synthase subunit d, putative
— Both
LbrM.35.4480
paraflagellar rod component, putative
— OG6
LbrM.24.2100 ⚠
tubulin folding cofactor D, putative
— Both
LbrM.33.2840 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LbrM.03.0700 ⚠
6-phosphofructo-2-kinase 1
— OG7
LbrM.35.0220 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
LbrM.07.0840 ⚠
6-phosphofructo-2-kinase-like protein
— OG7
LbrM.35.1280 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
LbrM.15.1160 ⚠
inositol/phosphatidylinositol phosphatase, pu
— OG7
LbrM.34.4210 ⚠
hypothetical protein, conserved
— OG7
LbrM.30.0540 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.27.0660 ⚠
replication factor C, subunit 4, putative
— OG7
LbrM.30.1330 ⚠
small nuclear ribonucleoprotein polypeptide e
— OG7
LbrM.35.4610 ⚠
ubiquitin protein ligase, putative
— OG7
LbrM.34.2400 ⚠
ubiquitin-protein ligase, putative
— OG7
LbrM.34.2360 ⚠
cysteine peptidase, Clan CA, family C19, puta
— OG7
LbrM.27.1390 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LbrM.12.0210 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
LbrM.21.1130 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LbrM.35.5510 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
LbrM.06.0920 ⚠
hypothetical protein, conserved
— OG7
LbrM.35.2170 ⚠
TLD, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.