LbrM.10.0310

isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100639 OG7: OG7_0004251 184 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 184 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.35.1020 ⚠
SNF1-related protein kinases, putative
— OG7
LbrM.32.1000
Alpha/beta hydrolase family, putative
— Both
LbrM.32.2280 ⚠
cytidylyltransferase, putative
— Both
LbrM.28.1190
WD domain, G-beta repeat, putative
— Both
LbrM.18.0310 ⚠
dephospho-CoA kinase, putative
— Both
LbrM.27.2510 ⚠
protein phosphatase-like protein
— OG6
LbrM.35.0620 ⚠
protein phosphatase 2C-like protein
— OG6
LbrM.30.0990 ⚠
protein phosphatase 2C, putative (fragment)
— OG6
LbrM.32.1860 ⚠
protein phosphatase 2C, putative
— OG6
LbrM.28.1220
electron-transfer-flavoprotein, alpha polypep
— Both
LbrM.23.1720
alanine racemase, putative
— Both
LbrM.22.0310
SEP domain containing protein, putative
— Both
LbrM.20.2050
protein phosphatase 2C-like protein
— OG6
LbrM.20.3380
phosphomannomutase-like protein
— Both
LbrM.35.0120 ⚠
stress-inducible protein STI1 homolog
— OG6
LbrM.27.2600 ⚠
TPR-repeat protein, putative
— OG6
LbrM.35.0680 ⚠
Elongation factor G1, mitochondrial, putative
— Both
LbrM.32.3210 ⚠
nucleoside diphosphate kinase b
— Both
LbrM.32.3200 ⚠
nucleoside diphosphate kinase b
— Both
LbrM.28.2260
tRNA threonylcarbamoyl adenosine modification
— Both
LbrM.35.4690 ⚠
mitochondrial intermediate peptidase, putativ
— Both
LbrM.20.4840 ⚠
hypothetical protein, conserved
— Both
LbrM.21.0070 ⚠
hypothetical protein, conserved
— Both
LbrM.32.0130
N-myristoyl transferase, putative
— Both
LbrM.01.0250
cyclophilin 12, putative
— OG6
LbrM.30.2040
alcohol dehydrogenase, putative
— Both
LbrM.16.0590
dihydroorotase, putative
— Both
LbrM.31.0140
ubiquitin carboxyl-terminal hydrolase, putati
— Both
LbrM.34.1390 ⚠
choline/ethanolamine kinase, putative
— Both
LbrM.33.1160
nicotinate phosphoribosyltransferase, putativ
— Both
LbrM.33.3090 ⚠
transcription elongation factor-like protein
— Both
LbrM.27.0800 ⚠
UBA/TS-N domain containing protein, putative
— Both
LbrM.03.0820 ⚠
inorganic pyrophosphatase, putative
— Both
LbrM.19.0110 ⚠
acidocalcisomal pyrophosphatase
— Both
LbrM.20.4800
cytidine triphosphate synthase, putative, CTP
— Both
LbrM.08.0510
hypothetical protein, conserved
— Both
LbrM.25.2310
hypothetical protein, conserved
— Both
LbrM.18.1050
UDP-glucose pyrophosphorylase
— Both
LbrM.35.3890
NUDIX hydrolase 3, putative
— Both
LbrM.12.0030
PITH domain-containing protein
— Both
LbrM.21.0210 ⚠
serine/threonine-protein kinase-like protein
— OG7
LbrM.13.0120 ⚠
Kinesin-13 2, putative
— OG7
LbrM.29.1990 ⚠
5'-AMP-activated protein kinase catalytic sub
— OG7
LbrM.28.2190 ⚠
protein lipid droplet kinase (LDK)
— OG7
LbrM.22.0750 ⚠
protein kinase, putative, serine/threonine pr
— OG7
LbrM.31.0400 ⚠
Kinesin-13 4, putative
— OG7
LbrM.27.2780 ⚠
metallo-peptidase, Clan MA(E), Family M3
— OG7
LbrM.26.1590 ⚠
metallo-peptidase, Clan MA(E), Family M3, thi
— OG7
LbrM.02.0670 ⚠
peptidyl dipeptidase, putative, metallo-pepti
— OG7
LbrM.30.1010 ⚠
adenosine kinase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.