LmjF.04.0120

exosome complex exonuclease RRP40, putative
Leishmania major strain Friedlin OG6: OG6_102463 OG7: OG7_0007513 172 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 172 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.25.0620 ⚠
RNA polymerase I second largest subunit, puta
— Both
LmjF.02.0320 ⚠
ribosomal RNA processing protein 41B, putativ
— Both
LmjF.14.0010
exosome complex exonuclease, putative
— Both
LmjF.36.3020 ⚠
Ribosomal RNA processing protein 41A
— Both
LmjF.36.4895 ⚠
exosome-associated protein 4, putative
— OG7
LmjF.20.0010 ⚠
DNA-directed RNA polymerase III, putative
— OG7
LmjF.31.0160 ⚠
DNA-directed RNA polymerase II subunit 2, put
— OG7
LmjF.22.1580 ⚠
exosome complex exonuclease RRP45 homolog, pu
— +2 more Both
LmjF.20.1360
exosome-associated protein 1, putative
— Both
LmjF.23.1770
exosome component CSL4, putative
— Both
LmjF.32.3460 ⚠
exosome-associated protein 2, putative
— +2 more Both
LmjF.28.2780 ⚠
heat-shock protein hsp70, putative
— Both
LmjF.18.1370 ⚠
heat shock protein 110, putative
— OG7
LmjF.26.1240 ⚠
heat shock protein 70-related protein
— Both
LmjF.25.1270
hypothetical protein, conserved
— Both
LmjF.25.1390 ⚠
Conserved hypothetical ATP binding protein, p
— Both
LmjF.03.0350
protein kinase, putative
— Both
LmjF.34.0840 ⚠
translation elongation factor 1-beta, putativ
— Both
LmjF.34.0820 ⚠
elongation factor 1-beta
— Both
LmjF.36.1430 ⚠
translation elongation factor 1-beta, putativ
— Both
LmjF.26.0480 ⚠
Conserved hypothetical ATP binding protein, p
— OG7
LmjF.35.3510 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
LmjF.28.0120 ⚠
DNA-direcetd RNA polymerase II, subunit 9, pu
— OG7
LmjF.27.2490 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LmjF.18.0600 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LmjF.21.1330 ⚠
RecF/RecN/SMC N terminal domain/SMC proteins
— OG7
LmjF.36.3060 ⚠
cullin-like protein
— OG7
LmjF.35.4910 ⚠
DNA replication licensing factor MCM9, putati
— OG7
LmjF.24.0910 ⚠
DNA replication licensing factor MCM5, putati
— OG7
LmjF.34.4530 ⚠
Phosphatidylinositol 3-kinase tor2
— OG7
LmjF.36.0600 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
LmjF.32.1360 ⚠
RNA capping enzyme, cytoplasmic
— OG7
LmjF.33.1930 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
LmjF.05.0400 ⚠
structural maintenance of chromosome (SMC), p
— OG7
LmjF.24.2290 ⚠
cullin-like protein-like protein
— OG7
LmjF.09.0250 ⚠
DNA replication licensing factor MCM4, putati
— OG7
LmjF.11.0400 ⚠
tubulin-tyrsoine ligase-like protein
— OG7
LmjF.04.0500 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LmjF.36.6320 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
LmjF.32.1400 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LmjF.36.6770 ⚠
beta adaptin, putative
— OG7
LmjF.31.2650 ⚠
acetoin dehydrogenase e3 component-like prote
— OG7
LmjF.30.3430 ⚠
protein mkt1, putative
— OG7
LmjF.31.2030 ⚠
ubiquitin-fusion protein
— OG7
LmjF.36.2410 ⚠
Cullin protein neddylation domain containing
— OG7
LmjF.23.1380 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LmjF.31.1900 ⚠
ubiquitin-fusion protein
— OG7
LmjF.35.3500 ⚠
zinc finger protein, putative
— OG7
LmjF.17.0930 ⚠
formin, putative
— OG7
LmjF.11.0990 ⚠
adaptin-related protein-like protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.