LmjF.34.4530

Phosphatidylinositol 3-kinase tor2
Leishmania major strain Friedlin OG6: OG6_100794 OG7: OG7_0001934 344 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 344 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.32.2850 ⚠
CS domain/TPR repeat/Tetratricopeptide repeat
— OG7
LmjF.31.2640 ⚠
2-oxoglutarate dehydrogenase, e3 component, l
— OG7
LmjF.31.2650 ⚠
acetoin dehydrogenase e3 component-like prote
— OG7
LmjF.29.1830 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
LmjF.36.5240 ⚠
glycosyl hydrolase, putative
— OG7
LmjF.33.1490 ⚠
hypothetical protein, conserved
— Both
LmjF.14.1170 ⚠
ras-like small GTPases, putative
— OG7
LmjF.26.1260 ⚠
hypothetical protein, unknown function
— OG7
LmjF.35.4260 ⚠
predicted zinc finger protein
— OG7
LmjF.35.3500 ⚠
zinc finger protein, putative
— OG7
LmjF.30.3710 ⚠
CPSF-domain protein, putative
— OG7
LmjF.26.1420 ⚠
FYVE zinc finger, putative
— OG7
LmjF.05.0890 ⚠
CPSF A subunit region, putative
— OG7
LmjF.18.0600 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LmjF.18.0460 ⚠
tubulin-specific chaperone, putative
— OG7
LmjF.17.0430 ⚠
hypothetical protein, conserved
— OG7
LmjF.11.0370 ⚠
hypothetical protein, conserved
— OG7
LmjF.16.0660 ⚠
hypothetical protein, conserved
— OG7
LmjF.28.1460 ⚠
Cell division control protein 48, putative
— OG7
LmjF.22.1630 ⚠
ccr4-not transcription complex subunit
— OG7
LmjF.12.0320 ⚠
Myotubularin-related protein, putative
— OG7
LmjF.20.1480 ⚠
Myotubularin-related protein, putative
— OG7
LmjF.25.0940 ⚠
hypothetical protein, conserved
— OG7
LmjF.17.0920 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.13.0500 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.23.1380 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LmjF.32.1400 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LmjF.23.0120 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.34.0360 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
LmjF.33.2780 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.05.0190 ⚠
Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type
— OG7
LmjF.11.0260 ⚠
hypothetical protein, conserved
— OG7
LmjF.10.0800 ⚠
hypothetical protein, conserved
— OG7
LmjF.16.1350 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
LmjF.36.1720 ⚠
neurobeachin/beige protein, putative
— OG7
LmjF.31.2610 ⚠
RNA polymerase ii largest subunit
— OG7
LmjF.23.1570 ⚠
neutral sphingomyelinase activation associate
— OG7
LmjF.08.0420 ⚠
hypothetical protein, conserved
— OG7
LmjF.15.0790 ⚠
hypothetical protein, unknown function
— OG7
LmjF.31.1400 ⚠
hypothetical protein, conserved
— OG7
LmjF.32.3170 ⚠
NADH dehydrogenase subunit NI8M, putative
— OG7
LmjF.16.1220 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.28.2110 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.25.1280 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.36.2410 ⚠
Cullin protein neddylation domain containing
— OG7
LmjF.24.2290 ⚠
cullin-like protein-like protein
— OG7
LmjF.36.3060 ⚠
cullin-like protein
— OG7
LmjF.30.0910 ⚠
ubiquitin-protein ligase, putative
— OG7
LmjF.30.1090 ⚠
WW domain containing protein, putative
— OG7
LmjF.16.1140 ⚠
WW domain containing protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.