LmjF.28.2110

Cullin family/Cullin protein neddylation domain containing protein, putative
Leishmania major strain Friedlin OG6: OG6_150916 OG7: OG7_0001577 135 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 135 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.17.0920 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.13.0500 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.23.1380 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LmjF.32.1400 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LmjF.33.2780 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LmjF.24.1660 ⚠
SpoU rRNA Methylase family, putative
— OG7
LmjF.34.2790 ⚠
hypothetical protein, conserved
— OG7
LmjF.14.1270 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
LmjF.30.0250 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.32.0720 ⚠
hypothetical protein, conserved
— OG7
LmjF.34.3940 ⚠
target of rapamycin kinase 3
— OG7
LmjF.28.0850 ⚠
DNA replication licensing factor MCM2, putati
— OG7
LmjF.29.1900 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.2700 ⚠
DNA replication licensing factor MCM3, putati
— OG7
LmjF.26.1420 ⚠
FYVE zinc finger, putative
— OG7
LmjF.29.1830 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
LmjF.32.1460 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
LmjF.35.3500 ⚠
zinc finger protein, putative
— OG7
LmjF.11.0990 ⚠
adaptin-related protein-like protein
— OG7
LmjF.32.2650 ⚠
SpoU rRNA Methylase family, putative
— OG7
LmjF.36.4210 ⚠
WD domain, G-beta repeat/Utp21 specific WD40
— OG7
LmjF.35.2490 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.1490 ⚠
Rab3 GTPase-activating protein catalytic subu
— OG7
LmjF.02.0120 ⚠
phosphatidylinositol kinase related protein,
— OG7
LmjF.35.4260 ⚠
predicted zinc finger protein
— OG7
LmjF.14.1170 ⚠
ras-like small GTPases, putative
— OG7
LmjF.30.3710 ⚠
CPSF-domain protein, putative
— OG7
LmjF.28.1980 ⚠
hypothetical protein, conserved
— OG7
LmjF.26.0600 ⚠
hypothetical protein, conserved
— OG7
LmjF.26.1260 ⚠
hypothetical protein, unknown function
— OG7
LmjF.19.0980 ⚠
FYVE zinc finger, putative
— OG7
LmjF.31.1210 ⚠
Protein of unknown function (DUF3638)/Protein
— OG7
LmjF.23.1570 ⚠
neutral sphingomyelinase activation associate
— OG7
LmjF.31.2610 ⚠
RNA polymerase ii largest subunit
— OG7
LmjF.36.1720 ⚠
neurobeachin/beige protein, putative
— OG7
LmjF.10.0800 ⚠
hypothetical protein, conserved
— OG7
LmjF.08.0010 ⚠
adaptor complex protein (AP) 3 delta subunit
— OG7
LmjF.18.0820 ⚠
hypothetical protein, conserved
— OG7
LmjF.23.0547 ⚠
hypothetical protein, conserved
— OG7
LmjF.04.0120 ⚠
exosome complex exonuclease RRP40, putative
— OG7
LmjF.18.0570 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.3510 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
LmjF.21.1330 ⚠
RecF/RecN/SMC N terminal domain/SMC proteins
— OG7
LmjF.05.0400 ⚠
structural maintenance of chromosome (SMC), p
— OG7
LmjF.07.0550 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.1320 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.0290 ⚠
RNA-binding protein, putative
— OG7
LmjF.14.0570 ⚠
WD domain, G-beta repeat, putative
— OG7
LmjF.11.0470 ⚠
pumillio protein 10, putative
— OG7
LmjF.03.0520 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.