LmjF.23.1570

neutral sphingomyelinase activation associated factor-like protein
Leishmania major strain Friedlin OG6: OG6_104527 OG7: OG7_0001358 228 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 228 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.35.1190 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LmjF.36.3220 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.5340 ⚠
Dynein heavy chain and region D6 of dynein mo
— OG7
LmjF.13.0750 ⚠
hypothetical protein, conserved
— OG7
LmjF.11.1010 ⚠
inositol-1,4,5-trisphosphate (IP3) 5-phosphat
— OG7
LmjF.32.0700 ⚠
ubiquitin-conjugating enzyme E2, putative
— OG7
LmjF.34.0320 ⚠
hypothetical protein, conserved
— OG7
LmjF.32.1850 ⚠
Chaperonin HSP60, mitochondrial
— OG7
LmjF.36.2030 ⚠
chaperonin HSP60, mitochondrial precursor
— OG7
LmjF.33.1490 ⚠
hypothetical protein, conserved
— OG7
LmjF.22.0880 ⚠
hypothetical protein, conserved
— OG7
LmjF.31.0130 ⚠
hypothetical protein, unknown function
— OG7
LmjF.02.0150 ⚠
Vps51/Vps67, putative
— OG7
LmjF.30.1600 ⚠
hypothetical protein, conserved
— OG7
LmjF.11.0370 ⚠
hypothetical protein, conserved
— OG7
LmjF.12.0280 ⚠
ornithine decarboxylase, putative
— OG7
LmjF.16.0660 ⚠
hypothetical protein, conserved
— OG7
LmjF.22.1630 ⚠
ccr4-not transcription complex subunit
— OG7
LmjF.21.1220 ⚠
hypothetical protein, conserved
— OG7
LmjF.17.0920 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.13.0500 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.23.1380 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LmjF.32.1400 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LmjF.11.0980 ⚠
HIT zinc finger, putative
— OG7
LmjF.34.0370 ⚠
Conserved oligomeric complex COG6, putative
— OG7
LmjF.34.0360 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
LmjF.16.1350 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
LmjF.11.0260 ⚠
hypothetical protein, conserved
— OG7
LmjF.10.0800 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.1490 ⚠
Rab3 GTPase-activating protein catalytic subu
— OG7
LmjF.32.1460 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
LmjF.33.2700 ⚠
DNA replication licensing factor MCM3, putati
— OG7
LmjF.26.1420 ⚠
FYVE zinc finger, putative
— OG7
LmjF.29.1830 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
LmjF.25.0620 ⚠
RNA polymerase I second largest subunit, puta
— OG7
LmjF.17.0930 ⚠
formin, putative
— OG7
LmjF.36.5620 ⚠
isoleucyl-tRNA synthetase, putative
— OG7
LmjF.35.3500 ⚠
zinc finger protein, putative
— OG7
LmjF.11.0990 ⚠
adaptin-related protein-like protein
— OG7
LmjF.36.4210 ⚠
WD domain, G-beta repeat/Utp21 specific WD40
— OG7
LmjF.31.2610 ⚠
RNA polymerase ii largest subunit
— OG7
LmjF.36.1730 ⚠
hypothetical protein, conserved
— OG7
LmjF.32.2650 ⚠
SpoU rRNA Methylase family, putative
— OG7
LmjF.19.0980 ⚠
FYVE zinc finger, putative
— OG7
LmjF.24.1110 ⚠
formin-like protein
— OG7
LmjF.30.3710 ⚠
CPSF-domain protein, putative
— OG7
LmjF.26.1260 ⚠
hypothetical protein, unknown function
— OG7
LmjF.26.0600 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.1280 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.31.1210 ⚠
Protein of unknown function (DUF3638)/Protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.