LmjF.22.1630

ccr4-not transcription complex subunit
Leishmania major strain Friedlin OG6: OG6_101138 OG7: OG7_0005422 148 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 148 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.21.0800
CCR4-NOT transcription complex subunit 1
— Both
LmjF.25.1840
General negative regulator of transcription s
— Both
LmjF.12.0350
CCR4-NOT transcription complex subunit 2, put
— Both
LmjF.34.4550
cell differentiation protein-like protein
— Both
LmjF.23.0020
hypothetical protein, conserved
— Both
LmjF.34.4530 ⚠
Phosphatidylinositol 3-kinase tor2
— OG7
LmjF.28.0850 ⚠
DNA replication licensing factor MCM2, putati
— Both
LmjF.04.0690
axonemal dynein light chain, putative
— Both
LmjF.16.1350 ⚠
DNA-directed rna polymerase I largest subunit
— Both
LmjF.19.0690 ⚠
Flagellum attachment zone protein 7
— OG6
LmjF.19.0680 ⚠
Flagellum attachment zone protein 7
— OG6
LmjF.15.0790
hypothetical protein, unknown function
— Both
LmjF.22.1590
hypothetical protein, conserved
— Both
LmjF.14.0570
WD domain, G-beta repeat, putative
— Both
LmjF.12.0610 ⚠
TPR repeat, putative
— Both
LmjF.06.1160
hypothetical protein, conserved
— Both
LmjF.16.0380 ⚠
tubulin tyrosine ligase, putative
— Both
LmjF.30.2190
RNA-binding protein, putative
— OG6
LmjF.09.1220
AAA family ATPase, putative
— Both
LmjF.05.1080 ⚠
Phosphatidylinositol 4-phosphate 5-kinase, pu
— OG7
LmjF.34.2450 ⚠
Sec7 domain containing protein, putative
— OG7
LmjF.34.2520 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LmjF.30.0910 ⚠
ubiquitin-protein ligase, putative
— OG7
LmjF.16.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.30.1090 ⚠
WW domain containing protein, putative
— OG7
LmjF.35.5390 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.05.0410 ⚠
TPR repeat, putative
— OG7
LmjF.27.2490 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LmjF.11.0400 ⚠
tubulin-tyrsoine ligase-like protein
— OG7
LmjF.32.2930 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LmjF.30.2280 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LmjF.18.0370 ⚠
tubulin tyrosine ligase protein, putative
— OG7
LmjF.35.4930 ⚠
tubulin tyrosine ligase, putative
— OG7
LmjF.29.0260 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LmjF.20.0790 ⚠
tubulin-tyrosine ligase, putative
— OG7
LmjF.31.2610 ⚠
RNA polymerase ii largest subunit
— OG7
LmjF.34.0360 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
LmjF.30.3370
hypothetical protein, conserved
— OG7
LmjF.13.1470 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LmjF.36.3060 ⚠
cullin-like protein
— OG7
LmjF.14.1270 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
LmjF.17.0930 ⚠
formin, putative
— OG7
LmjF.29.1830 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
LmjF.23.1570 ⚠
neutral sphingomyelinase activation associate
— OG7
LmjF.33.2700 ⚠
DNA replication licensing factor MCM3, putati
— OG7
LmjF.31.0160 ⚠
DNA-directed RNA polymerase II subunit 2, put
— OG7
LmjF.28.2110 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.16.1220 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LmjF.11.0990 ⚠
adaptin-related protein-like protein
— OG7
LmjF.24.1660 ⚠
SpoU rRNA Methylase family, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.