LmjF.31.0010

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
Leishmania major strain Friedlin OG6: OG6_103138 OG7: OG7_0007419 37 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 37 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.36.6780 ⚠
nuclear lim interactor-interacting factor, pu
— OG7
LmjF.32.1790
hypothetical protein, conserved
— Both
LmjF.36.4930
translation initiation factor 2 subunit, puta
— Both
LmjF.28.0890
ribonucleoside-diphosphate reductase large ch
— Both
LmjF.30.3320
hypothetical protein, conserved
— Both
LmjF.24.1730 ⚠
Calcium/calmodulin-dependent protein kinase k
— Both
LmjF.10.0840 ⚠
hypothetical protein, conserved
— Both
LmjF.35.2160 ⚠
adenine aminohydrolase
— OG7
LmjF.30.2590 ⚠
hypothetical protein, conserved
— OG7
LmjF.32.0100 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LmjF.36.4780
paraflagellar rod component, putative
— Both
LmjF.35.0190 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LmjF.26.0160 ⚠
nuclear lim interactor-interacting factor-lik
— OG7
LmjF.25.2030 ⚠
mitochondrial import inner membrane transloca
— OG7
LmjF.35.3520 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LmjF.29.2400 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LmjF.35.2620 ⚠
TFIIF-stimulated CTD phosphatase, putative
— OG7
LmjF.35.2320 ⚠
Calcium/calmodulin-dependent protein kinase k
— OG7
LmjF.11.0250 ⚠
Calcium/calmodulin-dependent protein kinase k
— OG7
LmjF.23.0710 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.36.3590 ⚠
cysteine synthase
— OG6
LmjF.29.2210
leucine-rich repeat-containing protein
— Both
LmjF.25.2110
KIF-1 binding protein C terminal, putative
— Both
LmjF.05.0220
dual specificity phosphatase-like protein
— OG6
LmjF.08.0990
DnaJ domain containing protein, putative
— Both
LmjF.13.0460
hypothetical protein, conserved
— Both
LmjF.21.0725 ⚠
Aminoacyltransferase ATEL1, putative
— Both
LmjF.23.0540 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.17.0250 ⚠
cystathionine beta-synthase
— Both
LmjF.24.2110
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— Both
LmjF.34.1410 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— Both
LmjF.34.1400 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— Both
LmjF.33.0780 ⚠
NLI interacting factor-like phosphatase, puta
— Both
LmjF.33.2050
hypothetical protein, conserved
— Both
LmjF.35.4050
Protein kinase PK6, putative, kinetoplastid k
— Both
LmjF.33.3250
hypothetical protein, conserved
— Both
LmjF.33.1020
PSP1 C-terminal conserved region, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.