LmjF.36.3590

cysteine synthase
Leishmania major strain Friedlin OG6: OG6_100154 OG7: OG7_0002171 75 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 75 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.07.0805 ⚠
N-acetylglucosamine-phosphate mutase, putativ
— OG6
LmjF.27.1870 ⚠
trypanothione synthetase
— Both
LmjF.26.0830 ⚠
aspartate--ammonia ligase, putative
— Both
LmjF.23.0540 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.23.0710 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.33.2610 ⚠
Mitochondrial-processing peptidase subunit al
— OG6
LmjF.04.0580 ⚠
spermidine synthase
— OG6
LmjF.29.2240 ⚠
Aminopeptidase M1, putative
— OG6
LmjF.20.0560 ⚠
cytidine triphosphate synthase, putative
— OG6
LmjF.30.1250 ⚠
pyridoxal kinase, putative
— OG6
LmjF.27.2050 ⚠
ribonucleoside-diphosphate reductase small ch
— OG6
LmjF.27.2030 ⚠
branched-chain amino acid aminotransferase, p
— OG6
LmjF.22.1290 ⚠
ribonucleoside-diphosphate reductase small ch
— OG6
LmjF.14.0350 ⚠
threonine synthase, putative
— OG6
LmjF.26.1240 ⚠
heat shock protein 70-related protein
— Both
LmjF.28.2780 ⚠
heat-shock protein hsp70, putative
— Both
LmjF.28.2820 ⚠
heat shock protein 70, putative
— OG6
LmjF.28.2770 ⚠
heat-shock protein hsp70, putative
— Both
LmjF.28.1200 ⚠
luminal binding protein 1 (BiP), putative
— Both
LmjF.24.0770 ⚠
malic enzyme, putative
— Both
LmjF.34.1400 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— OG6
LmjF.34.1410 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— OG6
LmjF.23.0460 ⚠
trypanothione synthetase, putative
— OG7
LmjF.36.5560 ⚠
aminopeptidase P1, putative
— OG7
LmjF.18.1370 ⚠
heat shock protein 110, putative
— OG7
LmjF.01.0640 ⚠
HSP70-like protein
— OG7
LmjF.26.0900 ⚠
heat shock 70 protein-like protein
— OG7
LmjF.35.4710 ⚠
170 kDa glucose-regulated protein, putative
— OG7
LmjF.29.1760 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.29.1770 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.29.1750 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.23.0690 ⚠
3-ketoacyl-CoA thiolase, putative
— OG6
LmjF.33.2830 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.33.2850 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.09.0840 ⚠
Uncharacterised protein family (UPF0160), put
— Both
LmjF.29.2800 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— OG6
LmjF.28.2860 ⚠
cytosolic malate dehydrogenase
— OG6
LmjF.24.2110 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— OG6
LmjF.36.6650 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— OG6
LmjF.27.2660 ⚠
peptidyl dipeptidase, putative
— OG6
LmjF.29.0940 ⚠
5-histidylcysteine sulfoxide synthase, putati
— OG6
LmjF.13.0160 ⚠
protein kinase A regulatory subunit
— OG6
LmjF.33.2300 ⚠
udp-glc 4'-epimerase, putative
— OG6
LmjF.25.2430 ⚠
Xaa-Pro aminopeptidase, putative
— OG6
LmjF.19.1440 ⚠
mitogen-activated protein kinase 4
— OG6
LmjF.17.0250 ⚠
cystathionine beta-synthase
— OG6
LmjF.23.1140 ⚠
hypothetical protein, conserved
— OG6
LmjF.31.0010 ⚠
5-methyltetrahydropteroyltriglutamate-homocys
— OG6
LmjF.18.0670 ⚠
citrate synthase, putative
— OG6
LmjF.30.0610 ⚠
nitrate reductase, putative
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.