LmjF.17.0250

cystathionine beta-synthase
Leishmania major strain Friedlin OG6: OG6_100154 OG7: OG7_0002172 85 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 85 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.07.0805 ⚠
N-acetylglucosamine-phosphate mutase, putativ
— +2 more Both
LmjF.27.1870 ⚠
trypanothione synthetase
— Both
LmjF.23.0540 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LmjF.26.0830 ⚠
aspartate--ammonia ligase, putative
— Both
LmjF.23.0710 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LmjF.09.0840 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
LmjF.28.2820 ⚠
heat shock protein 70, putative
— OG6
LmjF.29.2800 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— Both
LmjF.28.2860 ⚠
cytosolic malate dehydrogenase
— Both
LmjF.24.2110 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— Both
LmjF.36.6650 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LmjF.14.0350 ⚠
threonine synthase, putative
— Both
LmjF.23.0690 ⚠
3-ketoacyl-CoA thiolase, putative
— Both
LmjF.04.0580 ⚠
spermidine synthase
— Both
LmjF.29.2240 ⚠
Aminopeptidase M1, putative
— Both
LmjF.20.0560 ⚠
cytidine triphosphate synthase, putative
— Both
LmjF.30.1250 ⚠
pyridoxal kinase, putative
— Both
LmjF.27.2050 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LmjF.27.2030 ⚠
branched-chain amino acid aminotransferase, p
— Both
LmjF.22.1290 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LmjF.33.2610 ⚠
Mitochondrial-processing peptidase subunit al
— Both
LmjF.26.1240 ⚠
heat shock protein 70-related protein
— OG6
LmjF.28.2780 ⚠
heat-shock protein hsp70, putative
— OG6
LmjF.24.0770 ⚠
malic enzyme, putative
— OG6
LmjF.15.1200 ⚠
STE group serine/threonine-protein kinase, pu
— OG7
LmjF.27.0860
WD domain, G-beta repeat, putative
— OG7
LmjF.36.4450 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LmjF.34.3740 ⚠
serine palmitoyltransferase-like protein
— OG7
LmjF.35.0320 ⚠
serine palmitoyltransferase, putative
— OG7
LmjF.23.0460 ⚠
trypanothione synthetase, putative
— OG7
LmjF.12.1250 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
LmjF.33.2830 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.26.0300 ⚠
aminopeptidase-like protein
— OG7
LmjF.15.0240 ⚠
sterol carrier protein, putative
— OG7
LmjF.33.2850 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.21.0340 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.34.2820 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LmjF.32.3970 ⚠
cAMP response protein 1, putative
— OG7
LmjF.34.1500 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LmjF.25.1500 ⚠
PUA domain/NOL1/NOP2/sun family, putative
— OG7
LmjF.31.0190 ⚠
nucleolar protein, putative
— OG7
LmjF.28.1740 ⚠
NOL1/NOP2/sun family, putative
— OG7
LmjF.26.2000 ⚠
methyltransferase domain containing protein,
— OG7
LmjF.29.2000 ⚠
hypothetical protein, conserved
— OG7
LmjF.13.0870 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.18.0670 ⚠
citrate synthase, putative
— Both
LmjF.02.0040 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LmjF.25.0750 ⚠
protein phosphatase 2C, putative
— OG6
LmjF.30.0610 ⚠
nitrate reductase, putative
— OG6
LmjF.13.0160 ⚠
protein kinase A regulatory subunit
— Both
Page 1 of 2
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.