LmjF.24.0770

malic enzyme, putative
Leishmania major strain Friedlin OG6: OG6_100205 OG7: OG7_0002857 53 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 53 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.11.0630 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.26.0830
aspartate--ammonia ligase, putative
— Both
LmjF.12.0630
alanine aminotransferase
— Both
LmjF.23.0540 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.23.0710 ⚠
acetyl-CoA synthetase, putative
— Both
LmjF.33.0310 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
LmjF.30.1690
hypothetical protein, conserved
— Both
LmjF.31.3090
metallo-peptidase, Clan ME, Family M16
— Both
LmjF.27.1870 ⚠
trypanothione synthetase
— Both
LmjF.36.6650
2,3-bisphosphoglycerate-independent phosphogl
— Both
LmjF.33.2850 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.33.2830 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LmjF.23.0460 ⚠
trypanothione synthetase, putative
— OG7
LmjF.35.4710 ⚠
170 kDa glucose-regulated protein, putative
— OG7
LmjF.36.3590 ⚠
cysteine synthase
— Both
LmjF.11.0620 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.26.0900 ⚠
heat shock 70 protein-like protein
— OG7
LmjF.01.0640 ⚠
HSP70-like protein
— OG7
LmjF.18.1370 ⚠
heat shock protein 110, putative
— OG7
LmjF.29.1750 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.29.1770 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.29.1760 ⚠
paraflagellar rod protein 1D, putative
— OG7
LmjF.36.5560 ⚠
aminopeptidase P1, putative
— OG7
LmjF.32.2200 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
LmjF.25.2080 ⚠
elongation factor 2-like protein
— OG7
LmjF.03.0160 ⚠
ATP-binding cassette protein subfamily F, mem
— OG7
LmjF.19.0800 ⚠
ABC transport system ATP-binding protein, put
— OG7
LmjF.36.0180 ⚠
elongation factor 2
— Both
LmjF.18.0680 ⚠
citrate synthase, putative
— Both
LmjF.10.0290
isocitrate dehydrogenase [NADP], mitochondria
— +2 more Both
LmjF.24.0320 ⚠
fumarate hydratase, putative
— Both
LmjF.35.3340
6-phosphogluconate dehydrogenase, decarboxyla
— Both
LmjF.25.2130 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LmjF.29.1960 ⚠
Fumarate hydratase class I, cytosolic
— Both
LmjF.18.0670 ⚠
citrate synthase, putative
— Both
LmjF.04.0990
hypothetical protein, conserved
— Both
LmjF.14.1160
enolase
— Both
LmjF.35.2350 ⚠
aminopeptidase P, putative
— Both
LmjF.27.1850 ⚠
paraflagellar rod protein 5, putative
— Both
LmjF.36.0190 ⚠
elongation factor 2
— Both
LmjF.25.2140 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LmjF.18.0510
aconitase, putative
— Both
LmjF.36.2950
succinyl-CoA ligase [GDP-forming] beta-chain,
— Both
LmjF.29.0867
guanine deaminase, putative
— Both
LmjF.09.0840
Uncharacterised protein family (UPF0160), put
— Both
LmjF.33.2570 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
LmjF.28.2770 ⚠
heat-shock protein hsp70, putative
— Both
LmjF.17.0250 ⚠
cystathionine beta-synthase
— OG6
LmjF.35.3260
Peroxin 19
— Both
LmjF.28.1200 ⚠
luminal binding protein 1 (BiP), putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.