LmjF.31.3090

metallo-peptidase, Clan ME, Family M16
Leishmania major strain Friedlin OG6: OG6_100422 OG7: OG7_0002754 107 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 107 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.35.3260
Peroxin 19
— Both
LmjF.11.0420 ⚠
regulator of chromatin condensation, putative
— OG7
LmjF.31.1930 ⚠
dihydrouridine synthase (Dus), putative
— Both
LmjF.05.0230
hydrogenase, putative
— Both
LmjF.34.2020 ⚠
Regulator of chromosome condensation (RCC1) r
— Both
LmjF.34.4540
13 kDa deflagellation-inducible protein, puta
— Both
LmjF.34.2750
methyltransferase-like protein
— Both
LmjF.33.0310 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
LmjF.33.1030 ⚠
Protein prenyltransferase alpha subunit repea
— Both
LmjF.34.4060 ⚠
ubiquitin hydrolase, putative
— Both
LmjF.34.2810 ⚠
Carboxypeptidase-like protein
— Both
LmjF.34.2260
ATP-dependent RNA helicase-like protein
— OG6
LmjF.35.2450 ⚠
ubiquitin-protein ligase, putative
— Both
LmjF.36.6750 ⚠
prolyl endopeptidase
— OG7
LmjF.36.4060 ⚠
regulator of chromosome condensation 1-like p
— OG7
LmjF.36.2600 ⚠
cyclin-e binding protein 1-like protein
— OG7
LmjF.26.0750 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.33.0200 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.03.0160 ⚠
ATP-binding cassette protein subfamily F, mem
— OG7
LmjF.15.1300 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.19.0800 ⚠
ABC transport system ATP-binding protein, put
— OG7
LmjF.34.3960 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.26.0740 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.17.0240 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.35.1740 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.36.4030 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.36.4370 ⚠
ubiquitin protein ligase, putative
— OG7
LmjF.30.2270 ⚠
hypothetical protein, conserved
— OG7
LmjF.08.0310 ⚠
Isochorismatase family, putative
— OG7
LmjF.22.1480 ⚠
Mitochondrial glycoprotein, putative
— OG7
LmjF.05.0790 ⚠
Mitochondrial glycoprotein, putative
— OG7
LmjF.34.0030 ⚠
serine/threonine-protein kinase NAK, putative
— OG7
LmjF.10.1140 ⚠
Zinc finger, C3HC4 type (RING finger), putati
— OG7
LmjF.18.1570 ⚠
Zinc finger, C3HC4 type (RING finger), putati
— OG7
LmjF.09.1210 ⚠
Zinc finger, C3HC4 type (RING finger), putati
— OG7
LmjF.23.0310 ⚠
hypothetical protein, conserved
— OG7
LmjF.26.1370 ⚠
guanine nucleotide-binding protein-like prote
— OG7
LmjF.33.2400 ⚠
ras-like small GTPases, putative
— OG7
LmjF.05.0460 ⚠
GTPase, putative
— OG7
LmjF.35.5210 ⚠
GTP-binding protein, putative
— OG7
LmjF.16.0390 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
LmjF.17.0350 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.32.1090 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.31.2720 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.21.0340 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.13.0870 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LmjF.34.1140 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.36.0470 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LmjF.36.0180 ⚠
elongation factor 2
— OG7
LmjF.08.0300 ⚠
Isochorismatase family, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.