LmjF.35.2450

ubiquitin-protein ligase, putative
Leishmania major strain Friedlin OG6: OG6_146796 OG7: OG7_0002947 161 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 161 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.05.0610 ⚠
Surp module, putative
— OG7
LmjF.36.0190 ⚠
elongation factor 2
— OG7
LmjF.36.0180 ⚠
elongation factor 2
— OG7
LmjF.30.0730 ⚠
co-chaperone GrpE, putative
— OG7
LmjF.30.0735 ⚠
heat shock protein grpe
— OG7
LmjF.23.0490 ⚠
5'-AMP-activated protein kinase subunit beta,
— OG7
LmjF.30.2270 ⚠
hypothetical protein, conserved
— OG7
LmjF.07.0280 ⚠
ubiquitin-protein ligase-like, putative
— OG7
LmjF.30.0910 ⚠
ubiquitin-protein ligase, putative
— OG7
LmjF.16.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.30.1090 ⚠
WW domain containing protein, putative
— OG7
LmjF.35.5390 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.18.1320 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.0200 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.36.4030 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.12.0060 ⚠
ribonuclease mar1
— OG7
LmjF.08.0300 ⚠
Isochorismatase family, putative
— OG7
LmjF.08.0310 ⚠
Isochorismatase family, putative
— OG7
LmjF.16.0390 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
LmjF.19.1050 ⚠
hypothetical protein, unknown function
— OG7
LmjF.35.5210 ⚠
GTP-binding protein, putative
— OG7
LmjF.05.0460 ⚠
GTPase, putative
— OG7
LmjF.33.2400 ⚠
ras-like small GTPases, putative
— OG7
LmjF.26.1370 ⚠
guanine nucleotide-binding protein-like prote
— OG7
LmjF.23.0310 ⚠
hypothetical protein, conserved
— OG7
LmjF.25.1705 ⚠
LSM domain containing protein, putative
— OG7
LmjF.01.0710 ⚠
ubiquitin activating enzyme, putative
— OG7
LmjF.36.4060 ⚠
regulator of chromosome condensation 1-like p
— OG7
LmjF.26.0005 ⚠
Lsm7p protein, putative
— OG7
LmjF.08.0220 ⚠
ubiquitin-activating enzyme-like protein
— OG7
LmjF.35.4460 ⚠
sm-f snRNP core complex protein, putative
— OG7
LmjF.36.2600 ⚠
cyclin-e binding protein 1-like protein
— OG7
LmjF.32.1070 ⚠
small nuclear ribonucleoprotein, putative
— OG7
LmjF.26.0750 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.01.0160 ⚠
LSM domain containing protein, putative
— OG7
LmjF.30.1205 ⚠
small nuclear ribonucleoprotein polypeptide e
— OG7
LmjF.11.0420 ⚠
regulator of chromatin condensation, putative
— OG7
LmjF.31.2720 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.26.0740 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.17.0240 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.22.0650 ⚠
guide RNA associated protein, GAP2, putative
— OG7
LmjF.35.3200 ⚠
RNA-binding protein, putative
— OG7
LmjF.32.1040 ⚠
hypothetical protein, conserved
— OG7
LmjF.09.1100 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.4810 ⚠
BRCA1 C Terminus (BRCT) domain containing pro
— OG7
LmjF.33.2260 ⚠
glycosyl hydrolase-like protein
— OG7
LmjF.36.4920 ⚠
hypothetical protein, conserved
— OG7
LmjF.33.2980 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.0920 ⚠
hypothetical protein, conserved
— OG7
LmjF.20.0940 ⚠
cyclophilin 15, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.