LmjF.22.0650

guide RNA associated protein, GAP2, putative
Leishmania major strain Friedlin OG6: OG6_139815 OG7: OG7_0037740 144 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 144 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.18.0550
hypothetical protein, conserved
— Both
LmjF.33.1910
ribosome assembly protein RRB1, putative
— Both
LmjF.18.1320
hypothetical protein, conserved
— Both
LmjF.18.1210 ⚠
prolyl-tRNA synthetase, putative
— Both
LmjF.18.1220 ⚠
bifunctional aminoacyl-tRNA synthetase, putat
— Both
LmjF.28.0680 ⚠
Ankyrin repeats (3 copies), putative
— OG6
LmjF.10.1195 ⚠
hypothetical protein, conserved
— OG7
LmjF.30.0460 ⚠
aspartyl-tRNA synthetase, putative
— Both
LmjF.21.1650 ⚠
protein kinase PK4, putative
— Both
LmjF.28.1200 ⚠
luminal binding protein 1 (BiP), putative
— OG6
LmjF.03.0800 ⚠
6-phosphofructo-2-kinase 1
— Both
LmjF.21.1430
2-oxoisovalerate dehydrogenase alpha subunit,
— Both
LmjF.35.1180 ⚠
NADH-dependent fumarate reductase, putative
— Both
LmjF.36.3100
ATP synthase, putative
— Both
LmjF.30.3260 ⚠
Ankyrin repeats (3 copies), putative
— OG6
LmjF.20.1180 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.28.2820 ⚠
heat shock protein 70, putative
— Both
LmjF.28.2780 ⚠
heat-shock protein hsp70, putative
— OG6
LmjF.26.1240 ⚠
heat shock protein 70-related protein
— OG6
LmjF.30.1230
Zinc finger, C3HC4 type (RING finger), putati
— Both
LmjF.21.1340
ATP synthase, putative
— Both
LmjF.01.0610
DNA-damage inducible protein DDI1-like protei
— Both
LmjF.21.0895 ⚠
aspartyl-tRNA synthetase, putative
— Both
LmjF.36.5420
branch point binding protein, putative
— Both
LmjF.35.0830 ⚠
NADH-dependent fumarate reductase-like protei
— Both
LmjF.20.1185 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.24.2020
tubulin folding cofactor D, putative
— Both
LmjF.35.0900
hypothetical protein, conserved
— Both
LmjF.26.0860 ⚠
RNA-editing complex protein MP100, putative
— OG7
LmjF.29.2180 ⚠
Domain of unknown function (DUF4379), putativ
— OG7
LmjF.20.0950 ⚠
conserved protein, unknown function
— OG7
LmjF.01.0710 ⚠
ubiquitin activating enzyme, putative
— OG7
LmjF.25.1705 ⚠
LSM domain containing protein, putative
— OG7
LmjF.07.0280 ⚠
ubiquitin-protein ligase-like, putative
— OG7
LmjF.30.0730 ⚠
co-chaperone GrpE, putative
— OG7
LmjF.30.2630 ⚠
replication factor C, subunit 2, putative
— OG7
LmjF.35.4460 ⚠
sm-f snRNP core complex protein, putative
— OG7
LmjF.27.0550 ⚠
replication factor C, subunit 4, putative
— OG7
LmjF.16.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.14.1070 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.36.0080 ⚠
leucine carboxyl methyltransferase, putative
— OG7
LmjF.29.0290 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LmjF.36.0490 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LmjF.10.0160
hypothetical protein, conserved
— OG7
LmjF.36.4250 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.26.0420 ⚠
pseudouridylate synthase-like protein
— OG7
LmjF.34.2340 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
LmjF.26.0310 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
LmjF.36.1420 ⚠
Zn-finger in Ran binding protein and others,
— OG7
LmjF.36.1955 ⚠
TLD, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.