LmjF.03.0800

6-phosphofructo-2-kinase 1
Leishmania major strain Friedlin OG6: OG6_100250 OG7: OG7_0002306 153 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 153 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.35.2940 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— Both
LmjF.36.4230 ⚠
paraflagellar rod component, putative
— Both
LmjF.36.0080 ⚠
leucine carboxyl methyltransferase, putative
— OG7
LmjF.33.0550 ⚠
hypothetical protein, conserved
— Both
LmjF.26.0550 ⚠
galactofuranosyltransferase lpg1-like protein
— OG7
LmjF.01.0710 ⚠
ubiquitin activating enzyme, putative
— OG7
LmjF.35.1410 ⚠
threonyl-tRNA synthetase, putative
— OG7
LmjF.35.1860 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.34.4090 ⚠
GRIP domain containing protein, putative
— OG7
LmjF.33.1830 ⚠
dual specificity tyrosine-phosphorylation-reg
— OG7
LmjF.10.0270 ⚠
exonuclease, putative
— OG7
LmjF.25.2300 ⚠
Leucine Rich repeats (2 copies), putative
— OG7
LmjF.15.0180 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.19.1500 ⚠
Eukaryotic translation initiation factor 4E-2
— OG7
LmjF.20.0280 ⚠
developmentally regulated phosphoprotein-like
— OG7
LmjF.34.1220 ⚠
inositol 5-phosphatase-like protein
— OG7
LmjF.35.0700 ⚠
vacuolar ATP synthase subunit d, putative
— OG7
LmjF.36.6770 ⚠
beta adaptin, putative
— OG7
LmjF.36.5260 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
LmjF.30.0760 ⚠
hypothetical protein, conserved
— OG7
LmjF.19.1040 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
LmjF.12.0190 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.34.1990 ⚠
Zeta toxin, putative
— OG7
LmjF.34.4290 ⚠
nucleolar protein family a, putative
— OG7
LmjF.10.1200 ⚠
hypothetical protein, conserved
— OG7
LmjF.23.0110 ⚠
GDP-mannose pyrophosphorylase
— OG7
LmjF.35.3370 ⚠
hypothetical protein, conserved
— OG7
LmjF.29.0290 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LmjF.09.0740 ⚠
ubiquitin ligase, putative
— OG7
LmjF.30.0450 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
LmjF.12.0250 ⚠
cysteinyl-tRNA synthetase, putative
— OG7
LmjF.08.0410 ⚠
WD domain, G-beta repeat, putative
— OG7
LmjF.36.1150 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
LmjF.36.0490 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LmjF.28.2500 ⚠
Eukaryotic translation initiation factor 4E-3
— OG7
LmjF.10.0160 ⚠
hypothetical protein, conserved
— OG7
LmjF.35.4230 ⚠
synaptojanin (N-terminal domain), putative
— OG7
LmjF.15.1210 ⚠
inositol/phosphatidylinositol phosphatase, pu
— OG7
LmjF.36.4250 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.25.0010 ⚠
beta galactofuranosyl transferase
— OG7
LmjF.08.0220 ⚠
ubiquitin-activating enzyme-like protein
— OG7
LmjF.19.1020 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
LmjF.36.6350 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LmjF.35.2340 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LmjF.23.1630 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LmjF.26.0420 ⚠
pseudouridylate synthase-like protein
— OG7
LmjF.36.3090 ⚠
hypothetical protein, conserved
— OG7
LmjF.27.1340 ⚠
hypothetical protein, unknown function
— OG7
LmjF.26.1900 ⚠
hypothetical protein, conserved
— OG7
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.