LmjF.30.0450

Eukaryotic translation initiation factor 4E-4
Leishmania major strain Friedlin OG6: OG6_106272 OG7: OG7_0002303 202 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 202 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.33.0960 ⚠
nicotinate phosphoribosyltransferase, putativ
— OG7
LmjF.31.2810 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
LmjF.01.0210 ⚠
CUE domain/Domain of unknown function (DUF177
— OG7
LmjF.13.0080 ⚠
mitochondrial DNA polymerase I protein B, put
— OG7
LmjF.28.2430 ⚠
Vacuolar proton pump subunit B, putative
— OG7
LmjF.06.0940 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.1955 ⚠
TLD, putative
— OG7
LmjF.16.1340 ⚠
hypothetical protein, conserved
— OG7
LmjF.03.0760 ⚠
hypothetical protein, conserved
— OG7
LmjF.13.0730 ⚠
ubiquitin-like protein
— OG7
LmjF.27.0720 ⚠
UBA/TS-N domain containing protein, putative
— OG7
LmjF.36.0540 ⚠
ubiquitin-like protein, putative
— OG7
LmjF.15.0510 ⚠
ecotin, putative
— OG7
LmjF.15.0300 ⚠
Ecotin-like protein
— OG7
LmjF.26.1910 ⚠
deoxyhypusine hydroxylase, putative
— OG7
LmjF.36.3000 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.29.2100 ⚠
Present in the outer mitochondrial membrane p
— OG7
LmjF.29.0600 ⚠
hypothetical protein, conserved
— OG7
LmjF.30.0930 ⚠
conserved hypothetical protein, putative
— OG7
LmjF.28.2070 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
LmjF.32.0730 ⚠
Outer row dynein-assembly protein 7
— OG7
LmjF.36.4890 ⚠
hypothetical protein, conserved
— OG7
LmjF.22.0110 ⚠
GMP synthase [glutamine-hydrolysing]
— OG7
LmjF.16.1490 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.4500 ⚠
Protein of unknown function (DUF2870), putati
— OG7
LmjF.30.0660 ⚠
pdz domain containing protein, putative
— OG7
LmjF.34.3780 ⚠
phosphomannomutase-like protein
— OG7
LmjF.31.0140 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LmjF.28.2390 ⚠
WW domain containing protein, putative
— OG7
LmjF.17.1140 ⚠
WW domain containing protein, putative
— OG7
LmjF.30.0180 ⚠
2-hydroxy-3-oxopropionate reductase, putative
— OG7
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— OG7
LmjF.25.1020 ⚠
dehydrogenase-like protein
— OG7
LmjF.32.1580 ⚠
phosphomannose isomerase
— OG7
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— OG7
LmjF.29.1310 ⚠
carnitine/choline acetyltransferase, putative
— OG7
LmjF.19.1540 ⚠
choline/Carnitine o-acyltransferase-like prot
— OG7
LmjF.22.0310 ⚠
carnitine palmitoyltransferase-like protein
— OG7
LmjF.32.2400 ⚠
hypothetical protein, conserved
— OG7
LmjF.36.6430 ⚠
protein transport protein Sec23-like protein
— OG7
LmjF.17.1150 ⚠
5'-3' exoribonuclease B, putative
— OG7
LmjF.36.1790 ⚠
5'-3' exoribonuclease D, putative
— OG7
LmjF.06.0260 ⚠
5'-3' exoribonuclease A, putative
— OG7
LmjF.28.1380 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.28.1360 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.28.1370 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
LmjF.16.0760 ⚠
transaldolase, putative
— OG7
LmjF.03.0570 ⚠
quinone oxidoreductase, putative
— OG7
LmjF.26.0320 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic, p
— OG7
LmjF.28.1340 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.