LmjF.11.0210

acidocalcisomal pyrophosphatase
Leishmania major strain Friedlin OG6: OG6_100346 OG7: OG7_0003350 281 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 281 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.21.0895 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LmjF.01.0710 ⚠
ubiquitin activating enzyme, putative
— OG7
LmjF.30.0460 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LmjF.35.0030 ⚠
pyruvate kinase
— Both
LmjF.34.2340 ⚠
asparaginyl-tRNA synthetase, putative
— Both
LmjF.04.0450 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LmjF.20.1180 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.23.0110 ⚠
GDP-mannose pyrophosphorylase
— Both
LmjF.20.1185 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.08.0220 ⚠
ubiquitin-activating enzyme-like protein
— Both
LmjF.18.0210 ⚠
Activator of Hsp90 ATPase, N-terminal/Activat
— Both
LmjF.34.3970 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
LmjF.32.3750 ⚠
Methyltransferase TYW3, putative
— OG7
LmjF.31.2880 ⚠
aldehyde reductase, putative
— OG7
LmjF.27.2410 ⚠
aldo-keto reductase-like protein
— OG7
LmjF.08.0870 ⚠
hypothetical protein, unknown function
— OG7
LmjF.13.0130 ⚠
Kinesin-13 2
— OG7
LmjF.01.0030 ⚠
Kinesin-13 1, putative
— OG7
LmjF.13.1610 ⚠
Kinesin-13 5, putative
— OG7
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.33.2570 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.06.0880 ⚠
acyl-coenzyme a dehydrogenase, putative
— Both
LmjF.06.0950 ⚠
glucosamine-fructose-6-phosphate aminotransfe
— Both
LmjF.22.1240 ⚠
translation initiation factor IF-2, putative
— Both
LmjF.30.0560 ⚠
hypothetical protein, conserved
— Both
LmjF.35.0350 ⚠
hypothetical protein, conserved
— Both
LmjF.35.2730 ⚠
acyl-CoA dehydrogenase, putative
— Both
LmjF.25.1290 ⚠
NPL4 family, putative
— Both
LmjF.25.2010 ⚠
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola
— Both
LmjF.31.1070 ⚠
biotin/lipoate protein ligase-like protein
— Both
LmjF.29.2110 ⚠
UDP-glucose:glycoprotein glucosyltransferase,
— Both
LmjF.19.0800 ⚠
ABC transport system ATP-binding protein, put
— Both
LmjF.20.1150 ⚠
Pre-mRNA-splicing factor 38, putative
— Both
LmjF.18.0090 ⚠
alpha glucosidase II subunit, putative
— Both
LmjF.33.0090 ⚠
hypothetical protein, conserved
— Both
LmjF.35.4550 ⚠
hypothetical protein, conserved
— Both
LmjF.10.0200 ⚠
Mitogen-activated protein kinase 10, putative
— OG6
LmjF.35.0830 ⚠
NADH-dependent fumarate reductase-like protei
— Both
LmjF.18.0880 ⚠
cyclosporin 16, putative
— OG6
LmjF.36.6650 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LmjF.08.0410 ⚠
WD domain, G-beta repeat, putative
— Both
LmjF.34.3750 ⚠
hypothetical protein, conserved
— Both
LmjF.34.1990 ⚠
Zeta toxin, putative
— Both
LmjF.30.3130 ⚠
valyl-tRNA synthetase, putative
— Both
LmjF.36.6070 ⚠
disgorgin, putative
— Both
LmjF.34.4290 ⚠
nucleolar protein family a, putative
— Both
LmjF.10.1200 ⚠
hypothetical protein, conserved
— Both
LmjF.01.0610 ⚠
DNA-damage inducible protein DDI1-like protei
— Both
LmjF.35.4470 ⚠
Co-chaperone protein P23
— Both
LmjF.25.0870 ⚠
Atypical serine/threonine protein kinase BUD3
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.