LmjF.35.0030

pyruvate kinase
Leishmania major strain Friedlin OG6: OG6_100258 OG7: OG7_0002165 182 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 182 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— Both
LmjF.14.1190
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.29.2440 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— OG7
LmjF.04.0450 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LmjF.35.1190 ⚠
NADH-dependent fumarate reductase, putative
— Both
LmjF.06.0860
dihydrofolate reductase-thymidylate synthase
— Both
LmjF.13.1190
adenylosuccinate synthetase, putative
— Both
LmjF.01.0490 ⚠
long-chain-fatty-acid-CoA ligase, putative
— Both
LmjF.15.1480 ⚠
cAMP specific phosphodiesterase, putative
— Both
LmjF.34.3380
aldose 1-epimerase-like protein
— Both
LmjF.30.3520 ⚠
S-adenosylmethionine synthetase
— Both
LmjF.01.0500 ⚠
fatty acyl CoA synthetase 2, putative
— Both
LmjF.32.3260
glucosamine-6-phosphate isomerase, putative
— Both
LmjF.30.2970 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LmjF.35.1180 ⚠
NADH-dependent fumarate reductase, putative
— Both
LmjF.30.1550 ⚠
pseudouridine synthase A-like protein, putati
— Both
LmjF.11.0630 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
LmjF.30.3500 ⚠
S-adenosylmethionine synthetase
— Both
LmjF.30.2980 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LmjF.01.0520 ⚠
long-chain-fatty-acid-CoA ligase, putative
— Both
LmjF.01.0470 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LmjF.20.1180 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.24.2060
transketolase
— Both
LmjF.14.0130 ⚠
inosine-guanine nucleoside hydrolase, putativ
— Both
LmjF.35.0830 ⚠
NADH-dependent fumarate reductase-like protei
— Both
LmjF.20.1185 ⚠
calpain-like cysteine peptidase, putative
— OG6
LmjF.11.0620 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
LmjF.34.3780
phosphomannomutase-like protein
— Both
LmjF.32.0080
N-myristoyl transferase, putative
— Both
LmjF.31.0140
ubiquitin carboxyl-terminal hydrolase, putati
— Both
LmjF.30.1380 ⚠
amidohydrolase, putative
— Both
LmjF.20.1550 ⚠
amidohydrolase, putative
— Both
LmjF.20.1560 ⚠
amidohydrolase, putative
— Both
LmjF.20.1570 ⚠
amidohydrolase, putative
— Both
LmjF.28.2070
tRNA threonylcarbamoyl adenosine modification
— Both
LmjF.33.0960
nicotinate phosphoribosyltransferase, putativ
— Both
LmjF.33.2810 ⚠
transcription elongation factor-like protein
— Both
LmjF.01.0220
cyclophilin 12, putative
— OG6
LmjF.12.0530
glucose-6-phosphate isomerase
— Both
LmjF.06.1070
deoxyribose-phosphate aldolase, putative
— Both
LmjF.27.0720 ⚠
UBA/TS-N domain containing protein, putative
— Both
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.13.1610 ⚠
Kinesin-13 5, putative
— OG7
LmjF.01.0030 ⚠
Kinesin-13 1, putative
— OG7
LmjF.13.0130 ⚠
Kinesin-13 2
— OG7
LmjF.30.3240 ⚠
glutamyl-tRNA synthetase, putative
— OG7
LmjF.30.0450 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
LmjF.19.1500 ⚠
Eukaryotic translation initiation factor 4E-2
— OG7
LmjF.19.1480 ⚠
eukaryotic translation initiation factor-like
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.