LmjF.22.0110

GMP synthase [glutamine-hydrolysing]
Leishmania major strain Friedlin OG6: OG6_100862 OG7: OG7_0002018 172 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 172 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.06.0510 ⚠
U-box domain containing protein, putative
— OG7
LmjF.28.2240
hd phosphohydrolase family protein
— Both
LmjF.36.6250
small G-protein, putative
— OG6
LmjF.20.0600 ⚠
hypothetical protein, conserved
— Both
LmjF.18.0990
UDP-glucose pyrophosphorylase
— Both
LmjF.30.2600 ⚠
formate--tetrahydrofolate ligase
— OG6
LmjF.34.2000
pyroglutamyl-peptidase I (C15 family)
— Both
LmjF.18.0210
Activator of Hsp90 ATPase, N-terminal/Activat
— Both
LmjF.16.0580
dihydroorotase, putative
— Both
LmjF.26.2700
6-phosphogluconolactonase
— Both
LmjF.21.0040 ⚠
hypothetical protein, conserved
— Both
LmjF.36.6650
2,3-bisphosphoglycerate-independent phosphogl
— Both
LmjF.32.0910
Alpha/beta hydrolase family, putative
— Both
LmjF.31.0570
amino acid transporter aATP11, putative
— OG6
LmjF.10.0200
Mitogen-activated protein kinase 10, putative
— OG6
LmjF.33.0090
hypothetical protein, conserved
— Both
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.28.2070
tRNA threonylcarbamoyl adenosine modification
— Both
LmjF.22.0320
SEP domain containing protein, putative
— Both
LmjF.31.1070
biotin/lipoate protein ligase-like protein
— Both
LmjF.25.2010
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola
— Both
LmjF.25.1290
NPL4 family, putative
— Both
LmjF.36.2950
succinyl-CoA ligase [GDP-forming] beta-chain,
— Both
LmjF.28.1140
electron-transfer-flavoprotein, alpha polypep
— Both
LmjF.28.1110
WD domain, G-beta repeat, putative
— Both
LmjF.16.0760
transaldolase, putative
— Both
LmjF.27.2030
branched-chain amino acid aminotransferase, p
— Both
LmjF.07.0805
N-acetylglucosamine-phosphate mutase, putativ
— Both
LmjF.23.1480
alanine racemase, putative
— Both
LmjF.35.0360
enoyl-CoA hydratase/isomerase family protein,
— Both
LmjF.27.2330 ⚠
GTP binding protein, putative
— Both
LmjF.33.2810 ⚠
transcription elongation factor-like protein
— Both
LmjF.08.0870
hypothetical protein, unknown function
— OG7
LmjF.32.3110 ⚠
Serine hydrolase (FSH1)/50S ribosome-binding
— OG7
LmjF.27.1830 ⚠
GTP binding protein, putative
— OG7
LmjF.05.1225
hypothetical protein
— OG7
LmjF.27.2410 ⚠
aldo-keto reductase-like protein
— OG7
LmjF.18.0600 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LmjF.34.3970 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
LmjF.36.0540 ⚠
ubiquitin-like protein, putative
— OG7
LmjF.32.3660 ⚠
3-hydroxyisobutyryl-coenzyme a hydrolase-like
— OG7
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.21.0150 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
LmjF.28.2000 ⚠
protein lipid droplet kinase (LDK)
— OG7
LmjF.14.1170 ⚠
ras-like small GTPases, putative
— OG7
LmjF.35.4260 ⚠
predicted zinc finger protein
— OG7
LmjF.01.0210 ⚠
CUE domain/Domain of unknown function (DUF177
— OG7
LmjF.35.3500 ⚠
zinc finger protein, putative
— OG7
LmjF.28.1350 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.28.1340 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.