LmjF.34.2000

pyroglutamyl-peptidase I (C15 family)
Leishmania major strain Friedlin OG6: OG6_101530 OG7: OG7_0006024 142 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 142 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.16.1490
hypothetical protein, conserved
— Both
LmjF.28.2000 ⚠
protein lipid droplet kinase (LDK)
— OG7
LmjF.21.0240 ⚠
hexokinase, putative
— Both
LmjF.32.1690 ⚠
protein phosphatase 2C, putative
— OG6
LmjF.30.0380
phosphatase 2C, putative
— OG6
LmjF.36.0530 ⚠
protein phosphatase 2C-like protein
— OG6
LmjF.27.2320 ⚠
protein phosphatase 2C, putative
— OG6
LmjF.28.1140
electron-transfer-flavoprotein, alpha polypep
— Both
LmjF.23.1480
alanine racemase, putative
— Both
LmjF.22.0320
SEP domain containing protein, putative
— Both
LmjF.25.2130 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LmjF.25.2140 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LmjF.34.3780
phosphomannomutase-like protein
— Both
LmjF.36.0070 ⚠
stress-inducible protein STI1 homolog
— OG6
LmjF.27.2390 ⚠
TPR-repeat protein, putative
— OG6
LmjF.36.0570 ⚠
Elongation factor G1, mitochondrial, putative
— Both
LmjF.20.0600 ⚠
hypothetical protein, conserved
— Both
LmjF.21.0040 ⚠
hypothetical protein, conserved
— Both
LmjF.32.0080
N-myristoyl transferase, putative
— Both
LmjF.16.0580
dihydroorotase, putative
— Both
LmjF.31.0140
ubiquitin carboxyl-terminal hydrolase, putati
— Both
LmjF.28.2070
tRNA threonylcarbamoyl adenosine modification
— Both
LmjF.33.0960
nicotinate phosphoribosyltransferase, putativ
— Both
LmjF.33.2810 ⚠
transcription elongation factor-like protein
— Both
LmjF.01.0220
cyclophilin 12, putative
— OG6
LmjF.06.1070
deoxyribose-phosphate aldolase, putative
— Both
LmjF.27.0720 ⚠
UBA/TS-N domain containing protein, putative
— Both
LmjF.08.0480
hypothetical protein, conserved
— Both
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— Both
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.18.0990
UDP-glucose pyrophosphorylase
— Both
LmjF.12.0020
PITH domain-containing protein
— Both
LmjF.21.0150 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.36.0900 ⚠
SNF1-related protein kinases, putative
— OG7
LmjF.29.2020 ⚠
5'-AMP-activated protein kinase catalytic sub
— OG7
LmjF.13.1610 ⚠
Kinesin-13 5, putative
— OG7
LmjF.21.1740 ⚠
RNA polymerase II, putative
— OG7
LmjF.01.0110 ⚠
monothiol glutaredoxin, putative
— OG7
LmjF.28.1340 ⚠
haloacid dehalogenase-like hydrolase, putativ
— OG7
LmjF.28.1350 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.28.1360 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.28.1380 ⚠
haloacid dehalogenase-like hydrolase-like pro
— OG7
LmjF.17.1150 ⚠
5'-3' exoribonuclease B, putative
— OG7
LmjF.36.0540 ⚠
ubiquitin-like protein, putative
— OG7
LmjF.13.0730 ⚠
ubiquitin-like protein
— OG7
LmjF.28.2500 ⚠
Eukaryotic translation initiation factor 4E-3
— OG7
LmjF.30.0450 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
LmjF.24.0210 ⚠
transcription elongation factor, putative
— OG7
LmjF.19.1480 ⚠
eukaryotic translation initiation factor-like
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.