LmjF.28.2500

Eukaryotic translation initiation factor 4E-3
Leishmania major strain Friedlin OG6: OG6_134811 OG7: OG7_0002303 201 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 201 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.15.0510 ⚠
ecotin, putative
— OG7
LmjF.31.1610 ⚠
diphthine synthase-like protein
— OG7
LmjF.36.6650 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— OG7
LmjF.23.0320 ⚠
hypothetical protein, conserved
— OG7
LmjF.19.1040 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
LmjF.26.0320 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic, p
— OG7
LmjF.17.0550 ⚠
RNA-binding protein, putative
— OG7
LmjF.31.2810 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
LmjF.01.0210 ⚠
CUE domain/Domain of unknown function (DUF177
— OG7
LmjF.23.0543 ⚠
5'-3' exoribonuclease C, putative
— OG7
LmjF.09.1100 ⚠
hypothetical protein, conserved
— OG7
LmjF.13.0080 ⚠
mitochondrial DNA polymerase I protein B, put
— OG7
LmjF.13.1630 ⚠
mitochondrial DNA polymerase I protein D, put
— OG7
LmjF.22.1060 ⚠
small nuclear ribonucleoprotein, putative
— OG7
LmjF.12.0250 ⚠
cysteinyl-tRNA synthetase, putative
— OG7
LmjF.06.0940 ⚠
hypothetical protein, conserved
— OG7
LmjF.03.0450 ⚠
TLD domain protein, conserved
— OG7
LmjF.36.1955 ⚠
TLD, putative
— OG7
LmjF.16.1340 ⚠
hypothetical protein, conserved
— OG7
LmjF.11.0920 ⚠
Short C-terminal domain/PUB domain containing
— OG7
LmjF.03.0760 ⚠
hypothetical protein, conserved
— OG7
LmjF.13.0730 ⚠
ubiquitin-like protein
— OG7
LmjF.27.0720 ⚠
UBA/TS-N domain containing protein, putative
— OG7
LmjF.36.0540 ⚠
ubiquitin-like protein, putative
— OG7
LmjF.08.0410 ⚠
WD domain, G-beta repeat, putative
— OG7
LmjF.15.0660 ⚠
hypothetical protein, conserved
— OG7
LmjF.32.0730 ⚠
Outer row dynein-assembly protein 7
— OG7
LmjF.06.0260 ⚠
5'-3' exoribonuclease A, putative
— OG7
LmjF.36.1790 ⚠
5'-3' exoribonuclease D, putative
— OG7
LmjF.17.1150 ⚠
5'-3' exoribonuclease B, putative
— OG7
LmjF.33.0960 ⚠
nicotinate phosphoribosyltransferase, putativ
— OG7
LmjF.07.0940 ⚠
Domain of unknown function (DUF3437), putativ
— OG7
LmjF.30.0660 ⚠
pdz domain containing protein, putative
— OG7
LmjF.29.2360 ⚠
aspartyl aminopeptidase, putative
— OG7
LmjF.36.4500 ⚠
Protein of unknown function (DUF2870), putati
— OG7
LmjF.16.1490 ⚠
hypothetical protein, conserved
— OG7
LmjF.22.0110 ⚠
GMP synthase [glutamine-hydrolysing]
— OG7
LmjF.36.4890 ⚠
hypothetical protein, conserved
— OG7
LmjF.26.1220 ⚠
hypothetical protein, conserved
— OG7
LmjF.29.2100 ⚠
Present in the outer mitochondrial membrane p
— OG7
LmjF.15.0520 ⚠
ecotin, putative
— OG7
LmjF.15.0300 ⚠
Ecotin-like protein
— OG7
LmjF.26.1910 ⚠
deoxyhypusine hydroxylase, putative
— OG7
LmjF.03.0690 ⚠
DEAD/DEAH box helicase, putative
— OG7
LmjF.36.3000 ⚠
ATP-dependent RNA helicase, putative
— OG7
LmjF.30.0930 ⚠
conserved hypothetical protein, putative
— OG7
LmjF.22.0060 ⚠
transcription factor-like protein
— OG7
LmjF.28.2070 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
LmjF.24.0370 ⚠
aspartate aminotransferase, putative
— OG7
LmjF.29.0600 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.