LmjF.26.0320

C-1-tetrahydrofolate synthase, cytoplasmic, putative
Leishmania major strain Friedlin OG6: OG6_100216 OG7: OG7_0002739 222 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 222 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.25.2010 ⚠
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola
— Both
LmjF.28.0450 ⚠
DIS3-like exonuclease, putative
— OG6
LmjF.33.2810 ⚠
transcription elongation factor-like protein
— Both
LmjF.28.0060 ⚠
hypothetical protein, conserved
— Both
LmjF.22.1540 ⚠
alanyl-tRNA synthetase, putative
— OG6
LmjF.05.0820 ⚠
hypothetical protein, conserved
— OG6
LmjF.16.0040 ⚠
2OG-Fe(II) oxygenase superfamily, putative
— Both
LmjF.27.2330 ⚠
GTP binding protein, putative
— Both
LmjF.22.0320 ⚠
SEP domain containing protein, putative
— Both
LmjF.23.1480 ⚠
alanine racemase, putative
— Both
LmjF.28.1140 ⚠
electron-transfer-flavoprotein, alpha polypep
— Both
LmjF.28.1110 ⚠
WD domain, G-beta repeat, putative
— Both
LmjF.35.0820 ⚠
aspartate aminotransferase, putative
— Both
LmjF.24.0370 ⚠
aspartate aminotransferase, putative
— Both
LmjF.22.1240 ⚠
translation initiation factor IF-2, putative
— OG6
LmjF.18.0010 ⚠
kinetoplast polyadenylation/uridylation facto
— OG6
LmjF.22.0300 ⚠
hypothetical protein, conserved
— OG6
LmjF.06.0950 ⚠
glucosamine-fructose-6-phosphate aminotransfe
— OG6
LmjF.31.2600 ⚠
calreticulin, putative
— OG6
LmjF.16.0760 ⚠
transaldolase, putative
— Both
LmjF.11.0530 ⚠
hypothetical protein, conserved
— OG6
LmjF.26.1000 ⚠
glucosidase II beta subunit-like protein, put
— OG6
LmjF.22.0110 ⚠
GMP synthase [glutamine-hydrolysing]
— Both
LmjF.13.1100 ⚠
leucyl-tRNA synthetase, putative
— OG6
LmjF.30.1120 ⚠
importin alpha, putative
— OG6
LmjF.35.0350 ⚠
hypothetical protein, conserved
— OG6
LmjF.35.2730 ⚠
acyl-CoA dehydrogenase, putative
— OG6
LmjF.25.1290 ⚠
NPL4 family, putative
— Both
LmjF.36.6650 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LmjF.36.0890 ⚠
eukaryotic translation initiation factor 6 (e
— Both
LmjF.23.0110 ⚠
GDP-mannose pyrophosphorylase
— OG6
LmjF.36.6250 ⚠
small G-protein, putative
— OG6
LmjF.21.0810 ⚠
methionyl-tRNA synthetase
— OG6
LmjF.20.0600 ⚠
hypothetical protein, conserved
— Both
LmjF.18.0990 ⚠
UDP-glucose pyrophosphorylase
— Both
LmjF.14.1370 ⚠
tyrosyl-tRNA synthetase, putative
— OG6
LmjF.34.2000 ⚠
pyroglutamyl-peptidase I (C15 family)
— Both
LmjF.20.0250 ⚠
deoxyhypusine synthase, putative
— OG6
LmjF.16.0580 ⚠
dihydroorotase, putative
— Both
LmjF.18.0210 ⚠
Activator of Hsp90 ATPase, N-terminal/Activat
— Both
LmjF.26.2700 ⚠
6-phosphogluconolactonase
— Both
LmjF.21.0040 ⚠
hypothetical protein, conserved
— Both
LmjF.18.0090 ⚠
alpha glucosidase II subunit, putative
— OG6
LmjF.31.1070 ⚠
biotin/lipoate protein ligase-like protein
— Both
LmjF.29.2110 ⚠
UDP-glucose:glycoprotein glucosyltransferase,
— OG6
LmjF.28.2070 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
LmjF.19.0800 ⚠
ABC transport system ATP-binding protein, put
— OG6
LmjF.20.1150 ⚠
Pre-mRNA-splicing factor 38, putative
— OG6
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.18.0880 ⚠
cyclosporin 16, putative
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.