LmxM.03.0980

eukaryotic translation initiation factor 2 subunit alpha
Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_101220 OG7: OG7_0006220 48 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 48 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmxM.30.2070 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.26.1960
hypothetical protein, conserved
— Both
LmxM.13.1440
hypothetical protein, conserved
— Both
LmxM.29.1205 ⚠
small nuclear ribonucleoprotein polypeptide e
— Both
LmxM.34.3960 ⚠
protein kinase A catalytic subunit isoform 2
— OG6
LmxM.30.2060 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.29.1680 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.31.1270 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.36.3430 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.34.3560 ⚠
CRAL/TRIO, N-terminal domain/CRAL/TRIO domain
— OG7
LmxM.30.2050 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.30.1650 ⚠
MYND finger, putative
— OG7
LmxM.08.0550
translation initiation factor-like protein
— Both
LmxM.31.1260 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
LmxM.29.0890 ⚠
adenosine kinase-like protein
— OG7
LmxM.25.1020 ⚠
dehydrogenase-like protein
— OG7
LmxM.15.0090 ⚠
ATP-dependent protease ATPase subunit HslU1,
— OG7
LmxM.04.0070 ⚠
hypothetical protein, conserved
— OG7
LmxM.34.4460 ⚠
sm-f snRNP core complex protein, putative
— OG7
LmxM.09.1090 ⚠
translation initiation factor EIF-2B gamma su
— OG7
LmxM.26.0005 ⚠
Lsm7p protein, putative
— OG7
LmxM.25.1705 ⚠
LSM domain containing protein, putative
— OG7
LmxM.01.0160 ⚠
LSM domain containing protein, putative
— OG7
LmxM.31.1070 ⚠
small nuclear ribonucleoprotein, putative
— OG7
LmxM.29.0880 ⚠
adenosine kinase, putative
— Both
LmxM.26.1910
hypothetical protein, conserved
— Both
LmxM.11.0350 ⚠
14-3-3 protein 2, putative
— Both
LmxM.36.0581 ⚠
sec14, cytosolic factor
— Both
LmxM.20.0660
serine/threonine protein phosphatase 2A regul
— Both
LmxM.36.3210 ⚠
14-3-3 protein 1, putative
— Both
LmxM.18.1220 ⚠
prolyl-tRNA synthetase, putative,bifunctional
— Both
LmxM.21.0640
phosphoglucomutase, putative
— Both
LmxM.09.0600
cyclin 1
— Both
LmxM.18.1210 ⚠
bifunctional aminoacyl-tRNA synthetase, putat
— Both
LmxM.29.0180 ⚠
2-hydroxy-3-oxopropionate reductase, putative
— Both
LmxM.33.3600 ⚠
adenosine kinase-like protein
— Both
LmxM.05.1100 ⚠
methyltransferase domain containing protein,
— Both
LmxM.32.0570
hypothetical protein, conserved
— Both
LmxM.29.3300
UV excision repair RAD23-like protein
— Both
LmxM.09.0230 ⚠
ATP-dependent protease ATPase subunit HslU2
— Both
LmxM.32.2730
guide RNA associated protein 1, putative
— Both
LmxM.22.0650
guide RNA associated protein, GAP2, putative
— Both
LmxM.28.0510 ⚠
hypothetical protein, conserved
— Both
LmxM.34.4010 ⚠
protein kinase A catalytic subunit isoform 1
— OG6
LmxM.18.1080 ⚠
protein kinase A catalytic subunit 3
— OG6
LmxM.23.0490
5'-AMP-activated protein kinase subunit beta,
— Both
LmxM.09.1070 ⚠
eukaryotic translation initiation factor 2 su
— Both
LmxM.08.0130
hypothetical protein, conserved
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.