LmxM.18.1220

prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative

Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_100749 OG7: OG7_0002333 188 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 188 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LmxM.18.0550 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_180550.1 ↔ LdBPK_181230.1 OG6 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 LdBPK_180550.1 ↔ LdBPK_181230.1	Both
LmxM.18.1320 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_006238 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 TCSYLVIO_006238 ↔ TCSYLVIO_006246	Both
LmxM.32.1910 ⚠ ribosome assembly protein RRB1, putative	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	Both
LmxM.21.0895 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
LmxM.29.0460 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
LmxM.33.2340 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_342110.1 OG6 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 +1 more	Both
LmxM.24.2020 ⚠ tubulin folding cofactor D, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
LmxM.22.0650 ⚠ guide RNA associated protein, GAP2, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_220520.1 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_006246 OG7 LdBPK_181230.1 ↔ LdBPK_220520.1 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_006246	Both
LmxM.12.0250 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
LmxM.08.0410 ⚠ WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both
LmxM.33.3960 ⚠ HECT E3 ligase, putative	—	OG7 LdBPK_181230.1 ↔ LdBPK_321150.1	OG7
LmxM.29.1205 ⚠ small nuclear ribonucleoprotein polypeptide e	—	OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	OG7
LmxM.27.1620 ⚠ Eukaryotic translation initiation factor 4E-1	—	OG7 LdBPK_181220.1 ↔ LdBPK_300460.1 OG7 LdBPK_181230.1 ↔ LdBPK_300460.1	OG7
LmxM.30.0310 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_310320.1 OG7 LdBPK_181230.1 ↔ LdBPK_310320.1	OG7
LmxM.10.0195 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_181220.1 ↔ LdBPK_291830.1 OG7 LdBPK_181230.1 ↔ LdBPK_291830.1	OG7
LmxM.30.1480 ⚠ hypothetical protein, unknown function	—	OG6 LdBPK_181220.1 ↔ LdBPK_311510.1 OG6 LdBPK_181230.1 ↔ LdBPK_311510.1 OG7 LdBPK_181220.1 ↔ LdBPK_311510.1 OG7 LdBPK_181230.1 ↔ LdBPK_311510.1	Both
LmxM.30.1370 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	OG7
LmxM.36.0150 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
LmxM.26.0310 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
LmxM.29.1090 ⚠ WW domain containing protein, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LmxM.07.0280 ⚠ HECT E3 ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LmxM.34.5390 ⚠ HECT E3 ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LmxM.32.2570 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
LmxM.05.0850 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LmxM.08_29.0290 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LmxM.36.0490 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LmxM.18.0070 ⚠ zinc-finger of a C2HC-type/Double zinc ribbon	—	OG6 TCSYLVIO_006138 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	Both
LmxM.36.4230 ⚠ paraflagellar rod component, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006246	OG6
LmxM.18.1040 ⚠ putative 5-oxoprolinase, putative	—	OG6 LdBPK_181050.1 ↔ LdBPK_181220.1 OG6 LdBPK_181050.1 ↔ LdBPK_181230.1 OG7 LdBPK_181050.1 ↔ LdBPK_181220.1 OG7 LdBPK_181050.1 ↔ LdBPK_181230.1	Both
LmxM.29.1230 ⚠ Zinc finger, C3HC4 type (RING finger), putati	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_006246	Both
LmxM.19.1560 ⚠ inosine-5'-monophosphate dehydrogenase	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1 OG7 LdBPK_181220.1 ↔ LdBPK_191590.1 OG7 LdBPK_181230.1 ↔ LdBPK_191590.1	Both
LmxM.28.1910 ⚠ p21-C-terminal region-binding protein, putati	—	OG6 LdBPK_181220.1 ↔ LdBPK_282030.1 OG6 LdBPK_181230.1 ↔ LdBPK_282030.1 OG7 LdBPK_181220.1 ↔ LdBPK_282030.1 OG7 LdBPK_181230.1 ↔ LdBPK_282030.1	Both
LmxM.34.1730 ⚠ casein kinase II, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_351720.1 OG6 LdBPK_181230.1 ↔ LdBPK_351720.1	OG6
LmxM.29.0560 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_300580.1 OG6 LdBPK_181230.1 ↔ LdBPK_300580.1 OG7 LdBPK_181220.1 ↔ LdBPK_300580.1 OG7 LdBPK_181230.1 ↔ LdBPK_300580.1	Both
LmxM.19.1040 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_191010.1 OG6 LdBPK_181230.1 ↔ LdBPK_191010.1 OG7 LdBPK_181220.1 ↔ LdBPK_191010.1 OG7 LdBPK_181230.1 ↔ LdBPK_191010.1	Both
LmxM.34.0920 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_350940.1 OG7 LdBPK_181230.1 ↔ LdBPK_350940.1	Both
LmxM.17.0725 ⚠ GMP reductase	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1	OG6
LmxM.31.1090 ⚠ HECT E3 ligase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_321150.1 OG7 LdBPK_181230.1 ↔ LdBPK_321150.1	Both
LmxM.30.0250 ⚠ ATP-dependent RNA helicase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_310260.1	OG6
LmxM.26.0005 ⚠ Lsm7p protein, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_260010.1 OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	Both
LmxM.22.0590 ⚠ Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_006246	Both
LmxM.12.0510 ⚠ WW domain containing protein, putative	—	OG6 LdBPK_120470.1 ↔ LdBPK_181220.1 OG6 LdBPK_120470.1 ↔ LdBPK_181230.1 OG7 LdBPK_120470.1 ↔ LdBPK_181220.1 OG7 LdBPK_120470.1 ↔ LdBPK_181230.1	Both
LmxM.13.0940 ⚠ N(2), N(2)-dimethylguanosine tRNA methyltrans	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_006246	Both
LmxM.26.2320 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_262340.1 OG6 LdBPK_181230.1 ↔ LdBPK_262340.1 OG7 LdBPK_181220.1 ↔ LdBPK_262340.1 OG7 LdBPK_181230.1 ↔ LdBPK_262340.1	Both
LmxM.08_29.2490 ⚠ protein kinase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_292600.1 OG7 LdBPK_181230.1 ↔ LdBPK_292600.1	Both
LmxM.11.0890 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_110890.1 ↔ LdBPK_181220.1 OG6 LdBPK_110890.1 ↔ LdBPK_181230.1 OG7 LdBPK_110890.1 ↔ LdBPK_181220.1 OG7 LdBPK_110890.1 ↔ LdBPK_181230.1	Both
LmxM.34.3200 ⚠ RNA-binding protein, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_353250.1 OG6 LdBPK_181230.1 ↔ LdBPK_353250.1 OG7 LdBPK_181220.1 ↔ LdBPK_353250.1 OG7 LdBPK_181230.1 ↔ LdBPK_353250.1	Both
LmxM.30.0860 ⚠ ras-like small GTPases, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_310890.1 OG6 LdBPK_181230.1 ↔ LdBPK_310890.1	OG6
LmxM.32.2260 ⚠ glycosyl hydrolase-like protein	—	OG6 LdBPK_181230.1 ↔ LdBPK_332390.1 OG7 LdBPK_181230.1 ↔ LdBPK_332390.1	Both
LmxM.02.0310 ⚠ paraflagellar rod component, putative	—	OG6 LdBPK_020280.1 ↔ LdBPK_181220.1 OG6 LdBPK_020280.1 ↔ LdBPK_181230.1 OG7 LdBPK_020280.1 ↔ LdBPK_181220.1 OG7 LdBPK_020280.1 ↔ LdBPK_181230.1	Both

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