LmxM.32.2570

metallo-peptidase, Clan MF, Family M17

Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_105603 OG7: OG7_0003405 286 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 286 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LmxM.20.1570 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LmxM.29.1380 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LmxM.20.1550 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LmxM.20.1560 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LmxM.30.1130 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LmxM.34.0830 ⚠ NADH-dependent fumarate reductase-like protei	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
LmxM.36.4040 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_332700.1 ↔ LdBPK_364240.1 OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
LmxM.33.2340 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
LmxM.08.0410 ⚠ WD domain, G-beta repeat, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	OG7
LmxM.36.5620 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LmxM.34.1180 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
LmxM.29.0760 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	OG7
LmxM.07.0800 ⚠ flavoprotein subunit-like protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
LmxM.34.1190 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
LmxM.29.0460 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
LmxM.04.0330 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LmxM.21.0895 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
LmxM.01.0610 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 LdBPK_010630.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG7 LdBPK_010630.1 ↔ LdBPK_110630.1 OG7 LdBPK_010630.1 ↔ LdBPK_332700.1 +1 more	Both
LmxM.29.0560 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	OG7
LmxM.28.0450 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
LmxM.28.0330 ⚠ rrp44p homologue, putative	—	OG6 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
LmxM.17.0086 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.08_29.1700 ⚠ MORN repeat, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_291830.1	OG7
LmxM.19.0980 ⚠ FYVE zinc finger, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
LmxM.26.1260 ⚠ hypothetical protein, unknown function	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
LmxM.04.0250 ⚠ RNA pseudouridylate synthase-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
LmxM.11.0420 ⚠ regulator of chromatin condensation, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LmxM.23.1570 ⚠ neutral sphingomyelinase activation associate	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
LmxM.03.0060 ⚠ Met-10+ like-protein, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_160320.1 OG7 LdBPK_110640.1 ↔ LdBPK_160320.1 OG7 LdBPK_160320.1 ↔ LdBPK_332700.1	OG7
LmxM.24.1880 ⚠ cyclin 11, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
LmxM.15.0360 ⚠ RNA pseudouridylate synthase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
LmxM.34.3200 ⚠ RNA-binding protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_353250.1	OG7
LmxM.18.1210 ⚠ bifunctional aminoacyl-tRNA synthetase, putat	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
LmxM.19.0970 ⚠ peptidyl-prolyl cis-trans isomerase, macropha	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LmxM.36.0230 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LmxM.33.2020 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LmxM.19.1560 ⚠ inosine-5'-monophosphate dehydrogenase	—	OG7 LdBPK_110640.1 ↔ LdBPK_191590.1	OG7
LmxM.08_29.0600 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_220007.1 OG7 LdBPK_110630.1 ↔ LdBPK_290620.1	OG7
LmxM.19.1530 ⚠ peptidylprolyl isomerase-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LmxM.26.2350 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_262370.1	OG7
LmxM.22.0450 ⚠ Acetyltransferase (GNAT) family, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_130260.1 OG7 LdBPK_110640.1 ↔ LdBPK_130260.1 OG7 LdBPK_130260.1 ↔ LdBPK_332700.1	OG7
LmxM.27.1690 ⚠ mRNA export factor MEX67	—	OG7 LdBPK_110630.1 ↔ LdBPK_271580.1 OG7 LdBPK_110640.1 ↔ LdBPK_271580.1 OG7 LdBPK_271580.1 ↔ LdBPK_332700.1	OG7
LmxM.36.2600 ⚠ cyclin-e binding protein 1-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LmxM.30.0310 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
LmxM.10.0195 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_291830.1	OG7
LmxM.01.0710 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010542	OG7
LmxM.08.0220 ⚠ ubiquitin-activating enzyme-like protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010542	OG7
LmxM.33.1990 ⚠ Zeta toxin, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010958	OG7
LmxM.10.0270 ⚠ exonuclease, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010944	OG7
LmxM.31.2910 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7

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