C4B63_23g268

Tubulin-specific chaperone E
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102729 OG7: OG7_0005809 73 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 73 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_18g157
DNA ligase I
— Both
C4B63_294g18 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_7g323 ⚠
conserved hypothetical protein
— OG7
C4B63_16g162
conserved hypothetical protein
— Both
C4B63_34g313
casein kinase II, alpha chain
— OG6
C4B63_6g444
phosphonopyruvate decarboxylase
— Both
C4B63_18g214
S-adenosylmethionine decarboxylase proenzyme
— Both
C4B63_18g286
conserved hypothetical protein
— Both
C4B63_102g71 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_21g114 ⚠
oxidoreductase
— OG7
C4B63_22g80
tubulin-tyrosine ligase
— OG6
C4B63_30g290
mercaptopyruvate sulfurtransferase
— Both
C4B63_49g130 ⚠
Putative hydrolase C777.06c
— Both
C4B63_87g16 ⚠
pitrilysin-like metalloprotease
— Both
C4B63_42g192
N-alpha-acetyltransferase 25, NatB auxiliary
— Both
C4B63_49g131 ⚠
conserved hypothetical protein
— Both
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_21g280
ribonuclease mar1
— OG7
C4B63_40g73 ⚠
glycosyl hydrolase-like protein
— OG7
C4B63_301g7 ⚠
conserved hypothetical protein
— OG7
C4B63_63g31 ⚠
Carboxy-terminal domain RNA polymerase II pol
— OG7
C4B63_23g189 ⚠
Uncharacterized protein C2F7.02c
— OG7
C4B63_48g7 ⚠
NLI interacting factor-like phosphatase
— OG7
C4B63_28g37 ⚠
Cap-specific mRNA (nucleoside-2'-O-)-methyltr
— OG7
C4B63_11g24 ⚠
TFIIF-stimulated CTD phosphatase
— OG7
C4B63_2g833 ⚠
Probable C-terminal domain small phosphatase
— OG7
C4B63_168g23 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_263g16 ⚠
Programmed cell death protein 2-like
— OG7
C4B63_24g224
conserved hypothetical protein
— OG7
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_7g324 ⚠
Programmed cell death protein 2, C-terminal d
— OG7
C4B63_199g21 ⚠
oxidoreductase
— OG7
C4B63_19g271
conserved hypothetical protein
— OG7
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_22g69
serine/threonine protein phosphatase 2A regul
— Both
C4B63_8g37
conserved hypothetical protein
— Both
C4B63_23g190
conserved hypothetical protein
— Both
C4B63_25g221
UDP-sugar pyrophosphorylase
— Both
C4B63_4g375 ⚠
glucan 1,3-alpha-glucosidase
— Both
C4B63_246g3 ⚠
Tetratricopeptide repeat protein 4
— Both
C4B63_120g70 ⚠
Peptide chain release factor 1, mitochondrial
— Both
C4B63_84g34 ⚠
Tetratricopeptide repeat protein 4
— Both
C4B63_113g46
conserved hypothetical protein
— Both
C4B63_49g79
WD domain, G-beta repeat
— Both
C4B63_12g290 ⚠
Peptide chain release factor 1, mitochondrial
— Both
C4B63_227g2 ⚠
glucan 1,3-alpha-glucosidase
— Both
C4B63_6g214
2,3-bisphosphoglycerate-independent phosphogl
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.